Albumin roles in developing anticancer compounds
Albumin is an abundant protein in nature with several biological functions. In the human body, both in health and in illness, its transport function is highlighted by the binding to medicinal drugs and consequent distribution in the bloodstream to the site of action. This is particularly relevant fo...
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| Veröffentlicht in: | Medicinal chemistry research 2021-08, Vol.30 (8), p.1469-1495 |
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| creator | Ribeiro, Amélia Galdino Alves, Josival Emanuel Ferreira Soares, José Cleberson Santos dos Santos, Keriolaine Lima Jacob, Íris Trindade Tenório da Silva Ferreira, Cindy Juliane dos Santos, Jéssica Celerino de Azevedo, Rafael David Souto de Almeida, Sinara Mônica Vitalino de Lima, Maria do Carmo Alves |
| description | Albumin is an abundant protein in nature with several biological functions. In the human body, both in health and in illness, its transport function is highlighted by the binding to medicinal drugs and consequent distribution in the bloodstream to the site of action. This is particularly relevant for anticancer treatments, since this protein accumulates in the tumor microenvironment to supply the energetic demands of cancer cells. Different spectroscopy, thermodynamic and in silico studies techniques can be employed to verify how albumin binds to ligands by using either human serum albumin (HSA) or bovine serum albumin (BSA) due to their structural similarity. There is an increasing tendency to use albumin in analyses of absorption, distribution, metabolism and excretion (ADME) properties of anticancer molecules, which further demonstrated the promising character of this investigation for proposing new drugs. |
| doi_str_mv | 10.1007/s00044-021-02748-z |
| format | Article |
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In the human body, both in health and in illness, its transport function is highlighted by the binding to medicinal drugs and consequent distribution in the bloodstream to the site of action. This is particularly relevant for anticancer treatments, since this protein accumulates in the tumor microenvironment to supply the energetic demands of cancer cells. Different spectroscopy, thermodynamic and in silico studies techniques can be employed to verify how albumin binds to ligands by using either human serum albumin (HSA) or bovine serum albumin (BSA) due to their structural similarity. There is an increasing tendency to use albumin in analyses of absorption, distribution, metabolism and excretion (ADME) properties of anticancer molecules, which further demonstrated the promising character of this investigation for proposing new drugs.</description><subject>Anticancer properties</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Bovine serum albumin</subject><subject>Cancer</subject><subject>Drugs</subject><subject>Human serum albumin</subject><subject>Inorganic Chemistry</subject><subject>Medicinal Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Proteins</subject><subject>Review Article</subject><subject>Serum albumin</subject><subject>Spectroscopy</subject><subject>Tumor microenvironment</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMoOI7-AVcF19WbV5Msh8EXDLjRdUjTdOjQJjVpBefXG63gzsXlnMU558KH0DWGWwwg7hIAMFYCwfkEk-XxBK0w56yUmMBp9pA94YSeo4uUDgBUAOMrBJu-nofOFzH0LhXZNO7D9WHs_L4wfuqs8dbFwoZhDLNv0iU6a02f3NWvrtHbw_3r9qncvTw-bze70lKsphJToiRwR21NlVKUG8Mpx0LZChNMa-O4MoxLJzCWogVlhaRONqKVVVUrQtfoZtkdY3ifXZr0IczR55eacCYJCFLRnCJLysaQUnStHmM3mPipMehvMnohozMZ_UNGH3OJLqWUw37v4t_0P60vosFkxw</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Ribeiro, Amélia Galdino</creator><creator>Alves, Josival Emanuel Ferreira</creator><creator>Soares, José Cleberson Santos</creator><creator>dos Santos, Keriolaine Lima</creator><creator>Jacob, Íris Trindade Tenório</creator><creator>da Silva Ferreira, Cindy Juliane</creator><creator>dos Santos, Jéssica Celerino</creator><creator>de Azevedo, Rafael David Souto</creator><creator>de Almeida, Sinara Mônica Vitalino</creator><creator>de Lima, Maria do Carmo Alves</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-2605-4192</orcidid></search><sort><creationdate>20210801</creationdate><title>Albumin roles in developing anticancer compounds</title><author>Ribeiro, Amélia Galdino ; Alves, Josival Emanuel Ferreira ; Soares, José Cleberson Santos ; dos Santos, Keriolaine Lima ; Jacob, Íris Trindade Tenório ; da Silva Ferreira, Cindy Juliane ; dos Santos, Jéssica Celerino ; de Azevedo, Rafael David Souto ; de Almeida, Sinara Mônica Vitalino ; de Lima, Maria do Carmo Alves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-1329805e3cb399935aa535179c61213bae59a458e71187f09c783e8d7f866b923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anticancer properties</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Bovine serum albumin</topic><topic>Cancer</topic><topic>Drugs</topic><topic>Human serum albumin</topic><topic>Inorganic Chemistry</topic><topic>Medicinal Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Proteins</topic><topic>Review Article</topic><topic>Serum albumin</topic><topic>Spectroscopy</topic><topic>Tumor microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribeiro, Amélia Galdino</creatorcontrib><creatorcontrib>Alves, Josival Emanuel Ferreira</creatorcontrib><creatorcontrib>Soares, José Cleberson Santos</creatorcontrib><creatorcontrib>dos Santos, Keriolaine Lima</creatorcontrib><creatorcontrib>Jacob, Íris Trindade Tenório</creatorcontrib><creatorcontrib>da Silva Ferreira, Cindy Juliane</creatorcontrib><creatorcontrib>dos Santos, Jéssica Celerino</creatorcontrib><creatorcontrib>de Azevedo, Rafael David Souto</creatorcontrib><creatorcontrib>de Almeida, Sinara Mônica Vitalino</creatorcontrib><creatorcontrib>de Lima, Maria do Carmo Alves</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribeiro, Amélia Galdino</au><au>Alves, Josival Emanuel Ferreira</au><au>Soares, José Cleberson Santos</au><au>dos Santos, Keriolaine Lima</au><au>Jacob, Íris Trindade Tenório</au><au>da Silva Ferreira, Cindy Juliane</au><au>dos Santos, Jéssica Celerino</au><au>de Azevedo, Rafael David Souto</au><au>de Almeida, Sinara Mônica Vitalino</au><au>de Lima, Maria do Carmo Alves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Albumin roles in developing anticancer compounds</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>30</volume><issue>8</issue><spage>1469</spage><epage>1495</epage><pages>1469-1495</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>Albumin is an abundant protein in nature with several biological functions. 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| subjects | Anticancer properties Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Bovine serum albumin Cancer Drugs Human serum albumin Inorganic Chemistry Medicinal Chemistry Pharmacology/Toxicology Proteins Review Article Serum albumin Spectroscopy Tumor microenvironment |
| title | Albumin roles in developing anticancer compounds |
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