Protein arginine methylation: from enigmatic functions to therapeutic targeting

Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets. PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell metabolism; these fundamental processes are altered in many diseases. Mechanistically understanding how these enzymes fuel...

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Veröffentlicht in:	Nature reviews. Drug discovery 2021-07, Vol.20 (7), p.509-530
Hauptverfasser:	Wu, Qin, Schapira, Matthieu, Arrowsmith, Cheryl H., Barsyte-Lovejoy, Dalia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/535/1266 631/92/607/1172 Animals Arginine Arginine - metabolism Biomedical and Life Sciences Biomedicine Biotechnology Cancer Cancer Research Development and progression Dihydrofolate reductase DNA methylation Drug Delivery Systems Drug Discovery Drug therapy Enzyme inhibitors Enzyme Inhibitors - therapeutic use Enzymes Genetic aspects Genetic transcription Health aspects Homocysteine Humans Medicinal Chemistry Metabolism Metabolites Methylation Methyltransferases Molecular Medicine Nitric oxide Nitrogen Oncology Oncology, Experimental Pharmacology/Toxicology Physiological aspects Protein-Arginine N-Methyltransferases - antagonists & inhibitors Protein-Arginine N-Methyltransferases - metabolism Proteins Proteins - metabolism Review Article Vitamin B
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