An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum

Neuroligin is a postsynaptic cell-adhesion molecule that is involved in synapse formation and maturation by interacting with presynaptic neurexin. Mutations in neuroligin genes, including the arginine to cystein substitution at the 451st amino acid residue (R451C) of neuroligin-3 (NLGN3), have been...

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Veröffentlicht in:	Frontiers in neural circuits 2021-06, Vol.15, p.676891-676891
Hauptverfasser:	Lai, Esther Suk King, Nakayama, Hisako, Miyazaki, Taisuke, Nakazawa, Takanobu, Tabuchi, Katsuhiko, Hashimoto, Kouichi, Watanabe, Masahiko, Kano, Masanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid substitution Animals Autism Autism Spectrum Disorder Autistic Disorder - genetics Brain mapping Calcium Cell Adhesion Molecules, Neuronal Cerebellum climbing fibers Cytology developing cerebellum Functional magnetic resonance imaging Humans Laboratory animals Membrane Proteins Mice Mutants Mutation Mutation - genetics Nerve Tissue Proteins Neuroimaging neuroligin-3 mutation Neuroscience Pathophysiology Point mutation Purkinje cell Purkinje Cells Synapse elimination Synapses Synaptogenesis
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