Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis

We have previously reported a series of thiouracil analogs as bacterial SecA inhibitors. In this study, one potent thiouracil analog, SCA-15, was further evaluated for its inhibitory effects on SecA proteins and against strains of methicillin-resistant Staphylococcus aureus (MRSA) and Bacillus anthr...

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Veröffentlicht in:	Medicinal chemistry research 2021-07, Vol.30 (7), p.1341-1347
Hauptverfasser:	Jin, Jinshan, Chaudhary, Arpana, Hsieh, Ying-Hsin, Fante, Bamba, Wang, Binghe, Tai, Phang C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Antiinfectives and antibacterials Bacillus anthracis Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Efflux Inhibitors Inorganic Chemistry Medicinal Chemistry Methicillin Multidrug resistance Original Research Pharmacology/Toxicology Proteins Pumps Secretion Staphylococcus aureus Staphylococcus infections Toxins Virulence Virulence factors
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