Rapid characterization and pharmacokinetic study of aristolochic acid analogues using ion mobility mass spectrometry

Aristolochic acid analogues (AAAs), naturally existing in herbal Aristolochia and Asarum genera, were once widely used in traditional pharmacopeias because of their anti-inflammatory properties, but lately they were identified as potential nephrotoxins and mutagens. A method for rapid characterizati...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2021-07, Vol.413 (16), p.4247-4253
Hauptverfasser:	Zhang, Yanfen, Han, Yehua, Dong, Chenglong, Li, Chen, Liang, Tuo, Ling, Guannan, Nie, Honggang
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical Chemistry Animals Anti-inflammatory agents Aristolochia - chemistry Aristolochic acid Aristolochic Acids - blood Aristolochic Acids - chemistry Asarum - chemistry Biochemistry Biological properties Biological samples Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacokinetics Food Science Identification and classification Inflammation Ion Mobility Spectrometry - economics Ion Mobility Spectrometry - methods Ionic mobility Ions Laboratory Medicine Limit of Detection Male Mass spectrometry Mass spectroscopy Methods Mobility Monitoring/Environmental Analysis Mutagens Mutagens - chemistry Mutagens - pharmacokinetics Pharmacokinetics Pharmacology Phytochemicals Properties Rats Rats, Sprague-Dawley Research Paper Scientific imaging Spectroscopy Structure Vapor phases
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