Methylmercury-Induced Toxicopathologic Findings in Salivary Glands of Offspring Rats After Gestational and Lactational Exposure
Methylmercury (MeHg) is one of the main global pollutants. The vulnerability of fetus and newborn to MeHg-induced changes is extensively reported, making relevant investigation possible for alternative sample matrix for human biological monitoring for at this stage of life. This study aimed to chara...
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| Veröffentlicht in: | Biological trace element research 2021-08, Vol.199 (8), p.2983-2991 |
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| creator | Nascimento, Priscila Cunha Ferreira, Maria Karolina Martins Balbinot, Karolyny Martins Alves-Júnior, Sérgio Melo Viana Pinheiro, João de Jesus Silveira, Felipe Martins Martins, Manoela Domingues Crespo-Lopez, Maria Elena Lima, Rafael Rodrigues |
| description | Methylmercury (MeHg) is one of the main global pollutants. The vulnerability of fetus and newborn to MeHg-induced changes is extensively reported, making relevant investigation possible for alternative sample matrix for human biological monitoring for at this stage of life. This study aimed to characterize tissue change effects of environmental–experimental MeHg on salivary glands of offspring rats after pre- and postnatal exposure. For this, pregnant Wistar rats were orally exposed to MeHg (40 μg/kg BW/day) or only vehicle (control group), from the gestational period to the end of the lactation period. Salivary glands (SG) were collected from the offspring to analyze possible Hg levels and main findings by histopathological evaluations and CK19 and α-SMA immunostaining. The results indicated that Hg levels in SG of intoxicated offspring were associated with histologic abnormalities, such as acinar atrophy and an increase in the intercellular matrix among the acini, as well as damages in the architecture of epithelium and myoepithelial cells, evidenced by a decrease in immunostaining area. Thus, this is the first study to show in the literature the toxicopathologic findings on SG of offspring after pre- and postnatal exposure to MeHg. Moreover, it presents the SG as an attractive target to futures studies, mainly in children exposed to environmentally relevant doses. |
| doi_str_mv | 10.1007/s12011-020-02409-z |
| format | Article |
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The vulnerability of fetus and newborn to MeHg-induced changes is extensively reported, making relevant investigation possible for alternative sample matrix for human biological monitoring for at this stage of life. This study aimed to characterize tissue change effects of environmental–experimental MeHg on salivary glands of offspring rats after pre- and postnatal exposure. For this, pregnant Wistar rats were orally exposed to MeHg (40 μg/kg BW/day) or only vehicle (control group), from the gestational period to the end of the lactation period. Salivary glands (SG) were collected from the offspring to analyze possible Hg levels and main findings by histopathological evaluations and CK19 and α-SMA immunostaining. The results indicated that Hg levels in SG of intoxicated offspring were associated with histologic abnormalities, such as acinar atrophy and an increase in the intercellular matrix among the acini, as well as damages in the architecture of epithelium and myoepithelial cells, evidenced by a decrease in immunostaining area. Thus, this is the first study to show in the literature the toxicopathologic findings on SG of offspring after pre- and postnatal exposure to MeHg. Moreover, it presents the SG as an attractive target to futures studies, mainly in children exposed to environmentally relevant doses.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-020-02409-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abnormalities ; Atrophy ; Biochemistry ; Biomedical and Life Sciences ; Biomonitoring ; Biotechnology ; Dimethylmercury ; Environmental effects ; Epithelium ; Exocrine glands ; Exposure ; Fetuses ; Foetus ; Glands ; Histopathology ; Lactation ; Life Sciences ; Malformations ; Mercury ; Mercury (metal) ; Methyl mercury ; Methylmercury ; Nutrition ; Offspring ; Oncology ; Pollutants ; Salivary gland ; Salivary glands ; Vulnerability</subject><ispartof>Biological trace element research, 2021-08, Vol.199 (8), p.2983-2991</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-b43e84b26ed9698b8e439898759ac39bc258049a8f86167dd7cb8bd1c84efa1b3</citedby><cites>FETCH-LOGICAL-c352t-b43e84b26ed9698b8e439898759ac39bc258049a8f86167dd7cb8bd1c84efa1b3</cites><orcidid>0000-0003-1486-4013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-020-02409-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-020-02409-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Nascimento, Priscila Cunha</creatorcontrib><creatorcontrib>Ferreira, Maria Karolina Martins</creatorcontrib><creatorcontrib>Balbinot, Karolyny Martins</creatorcontrib><creatorcontrib>Alves-Júnior, Sérgio Melo</creatorcontrib><creatorcontrib>Viana Pinheiro, João de Jesus</creatorcontrib><creatorcontrib>Silveira, Felipe Martins</creatorcontrib><creatorcontrib>Martins, Manoela Domingues</creatorcontrib><creatorcontrib>Crespo-Lopez, Maria Elena</creatorcontrib><creatorcontrib>Lima, Rafael Rodrigues</creatorcontrib><title>Methylmercury-Induced Toxicopathologic Findings in Salivary Glands of Offspring Rats After Gestational and Lactational Exposure</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description>Methylmercury (MeHg) is one of the main global pollutants. The vulnerability of fetus and newborn to MeHg-induced changes is extensively reported, making relevant investigation possible for alternative sample matrix for human biological monitoring for at this stage of life. This study aimed to characterize tissue change effects of environmental–experimental MeHg on salivary glands of offspring rats after pre- and postnatal exposure. For this, pregnant Wistar rats were orally exposed to MeHg (40 μg/kg BW/day) or only vehicle (control group), from the gestational period to the end of the lactation period. Salivary glands (SG) were collected from the offspring to analyze possible Hg levels and main findings by histopathological evaluations and CK19 and α-SMA immunostaining. The results indicated that Hg levels in SG of intoxicated offspring were associated with histologic abnormalities, such as acinar atrophy and an increase in the intercellular matrix among the acini, as well as damages in the architecture of epithelium and myoepithelial cells, evidenced by a decrease in immunostaining area. Thus, this is the first study to show in the literature the toxicopathologic findings on SG of offspring after pre- and postnatal exposure to MeHg. Moreover, it presents the SG as an attractive target to futures studies, mainly in children exposed to environmentally relevant doses.</description><subject>Abnormalities</subject><subject>Atrophy</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomonitoring</subject><subject>Biotechnology</subject><subject>Dimethylmercury</subject><subject>Environmental effects</subject><subject>Epithelium</subject><subject>Exocrine glands</subject><subject>Exposure</subject><subject>Fetuses</subject><subject>Foetus</subject><subject>Glands</subject><subject>Histopathology</subject><subject>Lactation</subject><subject>Life Sciences</subject><subject>Malformations</subject><subject>Mercury</subject><subject>Mercury (metal)</subject><subject>Methyl mercury</subject><subject>Methylmercury</subject><subject>Nutrition</subject><subject>Offspring</subject><subject>Oncology</subject><subject>Pollutants</subject><subject>Salivary gland</subject><subject>Salivary 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Toxicopathologic Findings in Salivary Glands of Offspring Rats After Gestational and Lactational Exposure</title><author>Nascimento, Priscila Cunha ; Ferreira, Maria Karolina Martins ; Balbinot, Karolyny Martins ; Alves-Júnior, Sérgio Melo ; Viana Pinheiro, João de Jesus ; Silveira, Felipe Martins ; Martins, Manoela Domingues ; Crespo-Lopez, Maria Elena ; Lima, Rafael Rodrigues</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-b43e84b26ed9698b8e439898759ac39bc258049a8f86167dd7cb8bd1c84efa1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abnormalities</topic><topic>Atrophy</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomonitoring</topic><topic>Biotechnology</topic><topic>Dimethylmercury</topic><topic>Environmental effects</topic><topic>Epithelium</topic><topic>Exocrine 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nascimento, Priscila Cunha</au><au>Ferreira, Maria Karolina Martins</au><au>Balbinot, Karolyny Martins</au><au>Alves-Júnior, Sérgio Melo</au><au>Viana Pinheiro, João de Jesus</au><au>Silveira, Felipe Martins</au><au>Martins, Manoela Domingues</au><au>Crespo-Lopez, Maria Elena</au><au>Lima, Rafael Rodrigues</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methylmercury-Induced Toxicopathologic Findings in Salivary Glands of Offspring Rats After Gestational and Lactational Exposure</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>199</volume><issue>8</issue><spage>2983</spage><epage>2991</epage><pages>2983-2991</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Methylmercury (MeHg) is one of the main global pollutants. The vulnerability of fetus and newborn to MeHg-induced changes is extensively reported, making relevant investigation possible for alternative sample matrix for human biological monitoring for at this stage of life. This study aimed to characterize tissue change effects of environmental–experimental MeHg on salivary glands of offspring rats after pre- and postnatal exposure. For this, pregnant Wistar rats were orally exposed to MeHg (40 μg/kg BW/day) or only vehicle (control group), from the gestational period to the end of the lactation period. Salivary glands (SG) were collected from the offspring to analyze possible Hg levels and main findings by histopathological evaluations and CK19 and α-SMA immunostaining. The results indicated that Hg levels in SG of intoxicated offspring were associated with histologic abnormalities, such as acinar atrophy and an increase in the intercellular matrix among the acini, as well as damages in the architecture of epithelium and myoepithelial cells, evidenced by a decrease in immunostaining area. Thus, this is the first study to show in the literature the toxicopathologic findings on SG of offspring after pre- and postnatal exposure to MeHg. Moreover, it presents the SG as an attractive target to futures studies, mainly in children exposed to environmentally relevant doses.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12011-020-02409-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1486-4013</orcidid></addata></record> |
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| subjects | Abnormalities Atrophy Biochemistry Biomedical and Life Sciences Biomonitoring Biotechnology Dimethylmercury Environmental effects Epithelium Exocrine glands Exposure Fetuses Foetus Glands Histopathology Lactation Life Sciences Malformations Mercury Mercury (metal) Methyl mercury Methylmercury Nutrition Offspring Oncology Pollutants Salivary gland Salivary glands Vulnerability |
| title | Methylmercury-Induced Toxicopathologic Findings in Salivary Glands of Offspring Rats After Gestational and Lactational Exposure |
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