SCF‐Slimb is critical for Glycogen synthase kinase‐3β‐mediated suppression of TAF15‐induced neurotoxicity in Drosophila

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder characterized pathologically by motor neuron degeneration and associated with aggregation of RNA‐binding proteins. TATA‐binding protein‐associated factor 15 (TAF15) accumulates as cytoplasmic aggregates in neuronal cells, and...

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Veröffentlicht in:	Journal of neurochemistry 2021-06, Vol.157 (6), p.2119-2127
Hauptverfasser:	Choi, Hyun‐Jun, Joo Cha, Sun, Do, Hyeon‐Ah, Kim, Hyung‐Jun, Lee, Jang‐Won, Kim, Kiyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Aggregates Amyotrophic lateral sclerosis Archipelagoes Biocompatibility Brain Degeneration Drosophila Fruit flies Glycogen Glycogen synthase kinase 3 Glycogens GSK‐3β Immunohistochemistry In vivo methods and tests Insects Kinases Lithium lithium chloride Locomotor activity motor neuron Neurodegeneration Neurodegenerative diseases Neurotoxicity Phenotypes Proteins Retinal degeneration RNA-binding protein TAF15 Toxicity Western blotting
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