Synthesis of Alkyl Fluorides by Silver‐Catalyzed Radical Decarboxylative Fluorination of Cesium Oxalates

A combination of silver nitrate (AgNO3) catalyst and Selectfluor® was found to perform radical deoxyfluorination of cesium oxalates derived from corresponding alcohols. The reaction tolerates a wide range of functional groups and provides preferentially access to tertiary alkyl fluorides. Readily available from alcohols, cesium oxalates undergo radical deoxyfluorination reaction in the presence of silver salts catalyst and Selectfluor® to produce alkyl fluorides. Herein, the scope of the fluorination protocol and a brief mechanistic study is described.