Multi-sample estimation of centered log-ratio matrix in microbiome studies

In microbiome studies, one of the ways of studying bacterial abundances is to estimate bacterial composition based on the sequencing read counts. Various transformations are then applied to such compositional data for downstream statistical analysis, among which the centered log-ratio (clr) transfor...

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Veröffentlicht in:	arXiv.org 2021-06
Hauptverfasser:	Li, Yezheng, Li, Hongzhe, Cao, Yuanpei
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Bacteria Composition Datasets Empirical analysis Gene sequencing Maximum likelihood estimation Optimization Statistical analysis Statistical methods Transformations Upper bounds
Online-Zugang:	Volltext
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