Eco-friendly Mycogenic Synthesis of ZnO and CuO Nanoparticles for In Vitro Antibacterial, Antibiofilm, and Antifungal Applications
Mycogenic synthesis of medically applied zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) were exploited using Penicillium chrysogenum . The biogenesis and capping processes of the produced nano-metals were conducted by functional fungal extracellular enzymes and proteins. The obtained Zn...
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| Veröffentlicht in: | Biological trace element research 2021-07, Vol.199 (7), p.2788-2799 |
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| creator | Mohamed, Asem A. Abu-Elghait, Mohammed Ahmed, Nehad E. Salem, Salem S. |
| description | Mycogenic synthesis of medically applied zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) were exploited using
Penicillium chrysogenum
. The biogenesis and capping processes of the produced nano-metals were conducted by functional fungal extracellular enzymes and proteins. The obtained ZnO-NPs and CuO-NPs were characterized. Also, the antibacterial activity and minimum inhibitory concentration (MIC) values of ZnO-NPs and CuO-NPs were determined. Also, antibiofilm and antifungal activities were investigated. Results have demonstrated the ability of the bio-secreted proteins to cape and reduce ZnO and CuO to hexagonal and spherical ZnO-NPs and CuO-NPs with particle size at 9.0–35.0 nm and 10.5–59.7 nm, respectively. Both ZnO-NPs and CuO-NPs showed high antimicrobial activities not only against Gram-positive and Gram-negative bacteria but also against some phytopathogenic fungal strains. Besides this, those NPs showed varied antibiofilm effects against different microorganisms. Quantitative and qualitative analyses indicated that CuO-NPs had an effective antibiofilm activity against
Staphylococcus aureus
and therefore can be applied in diverse medical devices. Thus, the mycogenic green synthesized ZnO-NPs and CuO-NPs have the potential as smart nano-materials to be used in the medical field to limit the spread of some pathogenic microbes. |
| doi_str_mv | 10.1007/s12011-020-02369-4 |
| format | Article |
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Penicillium chrysogenum
. The biogenesis and capping processes of the produced nano-metals were conducted by functional fungal extracellular enzymes and proteins. The obtained ZnO-NPs and CuO-NPs were characterized. Also, the antibacterial activity and minimum inhibitory concentration (MIC) values of ZnO-NPs and CuO-NPs were determined. Also, antibiofilm and antifungal activities were investigated. Results have demonstrated the ability of the bio-secreted proteins to cape and reduce ZnO and CuO to hexagonal and spherical ZnO-NPs and CuO-NPs with particle size at 9.0–35.0 nm and 10.5–59.7 nm, respectively. Both ZnO-NPs and CuO-NPs showed high antimicrobial activities not only against Gram-positive and Gram-negative bacteria but also against some phytopathogenic fungal strains. Besides this, those NPs showed varied antibiofilm effects against different microorganisms. Quantitative and qualitative analyses indicated that CuO-NPs had an effective antibiofilm activity against
Staphylococcus aureus
and therefore can be applied in diverse medical devices. Thus, the mycogenic green synthesized ZnO-NPs and CuO-NPs have the potential as smart nano-materials to be used in the medical field to limit the spread of some pathogenic microbes.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-020-02369-4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antibacterial activity ; Antibiotics ; Antifungal activity ; Antifungal agents ; Bacteria ; Biochemistry ; Biogenesis ; Biomedical and Life Sciences ; Biotechnology ; Copper oxides ; Disease resistance ; Extracellular ; Extracellular enzymes ; Fungi ; Fungicides ; Gram-negative bacteria ; Heavy metals ; Life Sciences ; Medical equipment ; Metals ; Microbiological strains ; Microorganisms ; Minimum inhibitory concentration ; Nanoparticles ; Nutrition ; Oncology ; Pathogens ; Proteins ; Qualitative analysis ; Synthesis ; Zinc ; Zinc oxide ; Zinc oxides</subject><ispartof>Biological trace element research, 2021-07, Vol.199 (7), p.2788-2799</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-57a1e1e6791e34449e4036e145c98dd3a47113828e69d5a0dbf0bc34c4728e63</citedby><cites>FETCH-LOGICAL-c352t-57a1e1e6791e34449e4036e145c98dd3a47113828e69d5a0dbf0bc34c4728e63</cites><orcidid>0000-0003-2898-6708</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-020-02369-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-020-02369-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Mohamed, Asem A.</creatorcontrib><creatorcontrib>Abu-Elghait, Mohammed</creatorcontrib><creatorcontrib>Ahmed, Nehad E.</creatorcontrib><creatorcontrib>Salem, Salem S.</creatorcontrib><title>Eco-friendly Mycogenic Synthesis of ZnO and CuO Nanoparticles for In Vitro Antibacterial, Antibiofilm, and Antifungal Applications</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description>Mycogenic synthesis of medically applied zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) were exploited using
Penicillium chrysogenum
. The biogenesis and capping processes of the produced nano-metals were conducted by functional fungal extracellular enzymes and proteins. The obtained ZnO-NPs and CuO-NPs were characterized. Also, the antibacterial activity and minimum inhibitory concentration (MIC) values of ZnO-NPs and CuO-NPs were determined. Also, antibiofilm and antifungal activities were investigated. Results have demonstrated the ability of the bio-secreted proteins to cape and reduce ZnO and CuO to hexagonal and spherical ZnO-NPs and CuO-NPs with particle size at 9.0–35.0 nm and 10.5–59.7 nm, respectively. Both ZnO-NPs and CuO-NPs showed high antimicrobial activities not only against Gram-positive and Gram-negative bacteria but also against some phytopathogenic fungal strains. Besides this, those NPs showed varied antibiofilm effects against different microorganisms. Quantitative and qualitative analyses indicated that CuO-NPs had an effective antibiofilm activity against
Staphylococcus aureus
and therefore can be applied in diverse medical devices. Thus, the mycogenic green synthesized ZnO-NPs and CuO-NPs have the potential as smart nano-materials to be used in the medical field to limit the spread of some pathogenic microbes.</description><subject>Antibacterial activity</subject><subject>Antibiotics</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Bacteria</subject><subject>Biochemistry</subject><subject>Biogenesis</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Copper oxides</subject><subject>Disease resistance</subject><subject>Extracellular</subject><subject>Extracellular enzymes</subject><subject>Fungi</subject><subject>Fungicides</subject><subject>Gram-negative bacteria</subject><subject>Heavy metals</subject><subject>Life Sciences</subject><subject>Medical equipment</subject><subject>Metals</subject><subject>Microbiological strains</subject><subject>Microorganisms</subject><subject>Minimum inhibitory 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Mycogenic Synthesis of ZnO and CuO Nanoparticles for In Vitro Antibacterial, Antibiofilm, and Antifungal Applications</title><author>Mohamed, Asem A. ; Abu-Elghait, Mohammed ; Ahmed, Nehad E. ; Salem, Salem S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-57a1e1e6791e34449e4036e145c98dd3a47113828e69d5a0dbf0bc34c4728e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibacterial activity</topic><topic>Antibiotics</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Bacteria</topic><topic>Biochemistry</topic><topic>Biogenesis</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Copper oxides</topic><topic>Disease resistance</topic><topic>Extracellular</topic><topic>Extracellular enzymes</topic><topic>Fungi</topic><topic>Fungicides</topic><topic>Gram-negative bacteria</topic><topic>Heavy 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Trace Elem Res</stitle><date>2021-07-01</date><risdate>2021</risdate><volume>199</volume><issue>7</issue><spage>2788</spage><epage>2799</epage><pages>2788-2799</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Mycogenic synthesis of medically applied zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) were exploited using
Penicillium chrysogenum
. The biogenesis and capping processes of the produced nano-metals were conducted by functional fungal extracellular enzymes and proteins. The obtained ZnO-NPs and CuO-NPs were characterized. Also, the antibacterial activity and minimum inhibitory concentration (MIC) values of ZnO-NPs and CuO-NPs were determined. Also, antibiofilm and antifungal activities were investigated. Results have demonstrated the ability of the bio-secreted proteins to cape and reduce ZnO and CuO to hexagonal and spherical ZnO-NPs and CuO-NPs with particle size at 9.0–35.0 nm and 10.5–59.7 nm, respectively. Both ZnO-NPs and CuO-NPs showed high antimicrobial activities not only against Gram-positive and Gram-negative bacteria but also against some phytopathogenic fungal strains. Besides this, those NPs showed varied antibiofilm effects against different microorganisms. Quantitative and qualitative analyses indicated that CuO-NPs had an effective antibiofilm activity against
Staphylococcus aureus
and therefore can be applied in diverse medical devices. Thus, the mycogenic green synthesized ZnO-NPs and CuO-NPs have the potential as smart nano-materials to be used in the medical field to limit the spread of some pathogenic microbes.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12011-020-02369-4</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-2898-6708</orcidid></addata></record> |
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| subjects | Antibacterial activity Antibiotics Antifungal activity Antifungal agents Bacteria Biochemistry Biogenesis Biomedical and Life Sciences Biotechnology Copper oxides Disease resistance Extracellular Extracellular enzymes Fungi Fungicides Gram-negative bacteria Heavy metals Life Sciences Medical equipment Metals Microbiological strains Microorganisms Minimum inhibitory concentration Nanoparticles Nutrition Oncology Pathogens Proteins Qualitative analysis Synthesis Zinc Zinc oxide Zinc oxides |
| title | Eco-friendly Mycogenic Synthesis of ZnO and CuO Nanoparticles for In Vitro Antibacterial, Antibiofilm, and Antifungal Applications |
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