Ellagic Acid Prevents Ca2+ Dysregulation and Improves Functional Abnormalities of Ventricular Myocytes via Attenuation of Oxidative Stress in Pathological Cardiac Hypertrophy

The aim of this study was to investigate whether ellagic acid (EA) treatment can prevent changes in contractile function and Ca 2+ regulation of cardiomyocytes in pathologic cardiac hypertrophy. Groups were assigned as Con group; an ISO group in which the rats received isoproterenol alone (5 mg/kg/d...

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Veröffentlicht in:	Cardiovascular toxicology 2021-08, Vol.21 (8), p.630-641
Hauptverfasser:	Yamasan, Bilge E., Mercan, Tanju, Erkan, Orhan, Ozdemir, Semir
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Attenuation Biomedical and Life Sciences Biomedicine Ca2+/calmodulin-dependent protein kinase II Calcium (intracellular) Calcium channels (L-type) Calcium currents Calcium homeostasis Calcium ions Calcium signalling Cardiac muscle Cardiology Cardiomyocytes CYBB protein Ellagic acid Homeostasis Hypertrophy Isoproterenol Muscle contraction Myocytes Oxidative stress Pharmacology/Toxicology Protein expression Proteins Survival Ventricle Western blotting
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