NQO1, MPO, and the risk of lung cancer: A HuGE review

The aim of this study is to summarize the available molecular epidemiologic studies of lung cancer and metabolic genes, such as NAD(P)H quinone reductase 1 (NQO1) and myeloperoxidase (MPO). NQO1 plays a dual role in the detoxification and activation of procarcinogens whereas MPO has Phase I activity...

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Veröffentlicht in:	Genetics in medicine 2005-09, Vol.7 (7), p.463-478
Hauptverfasser:	Kiyohara, Chikako, Yoshimasu, Kouichi, Takayama, Koichi, Nakanishi, Yoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogens Genes Genetic Predisposition to Disease Granulocyte Colony-Stimulating Factor - genetics Humans Interleukin-3 - genetics Lung cancer Lung Neoplasms - epidemiology Lung Neoplasms - etiology Lung Neoplasms - genetics Meta-analysis Metabolism molecular epidemiology myeloperoxidase polymorphism NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H quinone oxidoreductase 1 polymorphism Polymorphism, Genetic Recombinant Fusion Proteins - genetics Recombinant Proteins Smoking
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