Associations of one-carbon metabolism-related gene polymorphisms with breast cancer risk are modulated by diet, being higher when adherence to the Mediterranean dietary pattern is low
Purpose Breast cancer is more likely attributed to a combination of genetic variations and lifestyle factors. Both one-carbon metabolism and diet-related factors could interfere with the carcinogenesis of breast cancer (BC), but whether diet consumed underlie a specific metabolism pathway could infl...
Gespeichert in:
| Veröffentlicht in: | Breast cancer research and treatment 2021-06, Vol.187 (3), p.793-804 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 804 |
|---|---|
| container_issue | 3 |
| container_start_page | 793 |
| container_title | Breast cancer research and treatment |
| container_volume | 187 |
| creator | Cao, Shang Zhu, Zheng Zhou, Jinyi Li, Wei Dong, Yunqiu Qian, Yun Wei, Pingmin Wu, Ming |
| description | Purpose
Breast cancer is more likely attributed to a combination of genetic variations and lifestyle factors. Both one-carbon metabolism and diet-related factors could interfere with the carcinogenesis of breast cancer (BC), but whether diet consumed underlie a specific metabolism pathway could influence the impact of genetic variants on breast cancer risk remains equivocal.
Methods
A case–control study of the Chinese female population (818 cases, 935 controls). 13 SNPs in eight one-carbon metabolism-related genes (
MTHFD1
,
TYMS
,
MTRR
,
MAT2B
,
CDO1
,
FOLR1
,
UNG2
,
ADA
) were performed. Diet was assessed by a validated food-frequency questionnaire. We examined the associations of the adherence to the Mediterranean dietary pattern (MDP) and single-nucleotide polymorphisms (SNPs) of one-carbon metabolism with breast cancer risk. We constructed an aggregate polygenic risk score (PRS) to test the additive effects of genetic variants and analyzed the gene–diet interactions.
Results
High adherence (highest quartile) to the MDP decreased the risk of breast cancer among post- but not premenopausal women, respectively (OR = 0.54, 95% CI = 0.38 to 0.78 and 0.90, 0.53 to 1.53). Neither of the polymorphisms or haplotypes was associated with breast cancer risk, irrespective of menopause. However, a high PRS (highest quartile) was associated with more than a doubling risk in both post- and premenopausal women, respectively (OR = 1.95, 95% CI = 1.32 to 2.87 and 2.09, 1.54 to 2.85). We found a gene–diet interaction with adherence to the MDP for aggregate PRS (
P
-interaction = 0.000) among postmenopausal women. When adherence to the MDP was low ( |
| doi_str_mv | 10.1007/s10549-021-06108-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2540280492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A666290542</galeid><sourcerecordid>A666290542</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-3470c1c59028e4ab49fe4ebfdb9324e6f06ad753be4e441cae7d986f29a538353</originalsourceid><addsrcrecordid>eNp9kstu1TAQhiMEoofCC7BAIyGxIsWOnYuXRxU3qYgNrC3HmSQuiR1sR0fnyfp6uCeFUgkhL2zNfP9YM_Nn2UtKLigh9btASclFTgqak4qSJm8eZTta1iyvC1o_znaEVnVeNaQ6y56FcE0IETURT7MzxkohmqrcZTf7EJw2KhpnA7genMVcK986CzNG1brJhDn3OKmIHQxoERY3HWfnlzFlAhxMHKH1qEIEraxGD96EH6A8wuy6dRO2R-gMxrfQorEDjGYYE3gY0YLq0hOTEKKDOCJ8wc5E9F5ZVPYkU_4Ii4opaMEEmNzhefakV1PAF3f3efb9w_tvl5_yq68fP1_ur3LNaxZzxmuiqS4FKRrkquWiR45t37WCFRyrnlSqq0vWpijnVCusuzSYvhCqZA0r2Xn2equ7ePdzxRDltVu9TV_KouSpKuGiuKcGNaE0tnfRKz2boOW-qqpCpEXdUhf_oNLpcDY6Db43Kf5A8OYvwYhqimNw03pa1kOw2EDtXQgee7l4M6epSUrkrVfk5hWZvCJPXpFNEr26a21tZ-z-SH6bIwFsA0JK2QH9fe__KfsLmSzLxA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2540280492</pqid></control><display><type>article</type><title>Associations of one-carbon metabolism-related gene polymorphisms with breast cancer risk are modulated by diet, being higher when adherence to the Mediterranean dietary pattern is low</title><source>SpringerLink Journals - AutoHoldings</source><creator>Cao, Shang ; Zhu, Zheng ; Zhou, Jinyi ; Li, Wei ; Dong, Yunqiu ; Qian, Yun ; Wei, Pingmin ; Wu, Ming</creator><creatorcontrib>Cao, Shang ; Zhu, Zheng ; Zhou, Jinyi ; Li, Wei ; Dong, Yunqiu ; Qian, Yun ; Wei, Pingmin ; Wu, Ming</creatorcontrib><description>Purpose
Breast cancer is more likely attributed to a combination of genetic variations and lifestyle factors. Both one-carbon metabolism and diet-related factors could interfere with the carcinogenesis of breast cancer (BC), but whether diet consumed underlie a specific metabolism pathway could influence the impact of genetic variants on breast cancer risk remains equivocal.
Methods
A case–control study of the Chinese female population (818 cases, 935 controls). 13 SNPs in eight one-carbon metabolism-related genes (
MTHFD1
,
TYMS
,
MTRR
,
MAT2B
,
CDO1
,
FOLR1
,
UNG2
,
ADA
) were performed. Diet was assessed by a validated food-frequency questionnaire. We examined the associations of the adherence to the Mediterranean dietary pattern (MDP) and single-nucleotide polymorphisms (SNPs) of one-carbon metabolism with breast cancer risk. We constructed an aggregate polygenic risk score (PRS) to test the additive effects of genetic variants and analyzed the gene–diet interactions.
Results
High adherence (highest quartile) to the MDP decreased the risk of breast cancer among post- but not premenopausal women, respectively (OR = 0.54, 95% CI = 0.38 to 0.78 and 0.90, 0.53 to 1.53). Neither of the polymorphisms or haplotypes was associated with breast cancer risk, irrespective of menopause. However, a high PRS (highest quartile) was associated with more than a doubling risk in both post- and premenopausal women, respectively (OR = 1.95, 95% CI = 1.32 to 2.87 and 2.09, 1.54 to 2.85). We found a gene–diet interaction with adherence to the MDP for aggregate PRS (
P
-interaction = 0.000) among postmenopausal women. When adherence to the MDP was low (< median), carries with high PRS (highest quartile) had higher BC risk (OR = 2.80, 95% CI = 1.55 to 5.07) than low PRS (lowest quartile), while adherence to the MDP was high (≥ median), the association disappeared (OR = 1.57, 95% CI = 0.92 to 2.66).
Conclusion
High adherence to the MDP may counteract the genetic predisposition associated with one-carbon metabolism on breast cancer risk in postmenopausal women.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-021-06108-8</identifier><identifier>PMID: 33599865</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Breast cancer ; Cancer ; Cancer research ; Carbon ; Carcinogenesis ; Diet ; Epidemiology ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic diversity ; Genetic research ; Haplotypes ; Medicine ; Medicine & Public Health ; Menopause ; Metabolism ; Oncology ; Oncology, Experimental ; Physiological aspects ; Post-menopause ; Postmenopausal women ; Risk factors ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Womens health</subject><ispartof>Breast cancer research and treatment, 2021-06, Vol.187 (3), p.793-804</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-3470c1c59028e4ab49fe4ebfdb9324e6f06ad753be4e441cae7d986f29a538353</citedby><cites>FETCH-LOGICAL-c473t-3470c1c59028e4ab49fe4ebfdb9324e6f06ad753be4e441cae7d986f29a538353</cites><orcidid>0000-0002-8798-0288</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-021-06108-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-021-06108-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33599865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Shang</creatorcontrib><creatorcontrib>Zhu, Zheng</creatorcontrib><creatorcontrib>Zhou, Jinyi</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Dong, Yunqiu</creatorcontrib><creatorcontrib>Qian, Yun</creatorcontrib><creatorcontrib>Wei, Pingmin</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><title>Associations of one-carbon metabolism-related gene polymorphisms with breast cancer risk are modulated by diet, being higher when adherence to the Mediterranean dietary pattern is low</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Purpose
Breast cancer is more likely attributed to a combination of genetic variations and lifestyle factors. Both one-carbon metabolism and diet-related factors could interfere with the carcinogenesis of breast cancer (BC), but whether diet consumed underlie a specific metabolism pathway could influence the impact of genetic variants on breast cancer risk remains equivocal.
Methods
A case–control study of the Chinese female population (818 cases, 935 controls). 13 SNPs in eight one-carbon metabolism-related genes (
MTHFD1
,
TYMS
,
MTRR
,
MAT2B
,
CDO1
,
FOLR1
,
UNG2
,
ADA
) were performed. Diet was assessed by a validated food-frequency questionnaire. We examined the associations of the adherence to the Mediterranean dietary pattern (MDP) and single-nucleotide polymorphisms (SNPs) of one-carbon metabolism with breast cancer risk. We constructed an aggregate polygenic risk score (PRS) to test the additive effects of genetic variants and analyzed the gene–diet interactions.
Results
High adherence (highest quartile) to the MDP decreased the risk of breast cancer among post- but not premenopausal women, respectively (OR = 0.54, 95% CI = 0.38 to 0.78 and 0.90, 0.53 to 1.53). Neither of the polymorphisms or haplotypes was associated with breast cancer risk, irrespective of menopause. However, a high PRS (highest quartile) was associated with more than a doubling risk in both post- and premenopausal women, respectively (OR = 1.95, 95% CI = 1.32 to 2.87 and 2.09, 1.54 to 2.85). We found a gene–diet interaction with adherence to the MDP for aggregate PRS (
P
-interaction = 0.000) among postmenopausal women. When adherence to the MDP was low (< median), carries with high PRS (highest quartile) had higher BC risk (OR = 2.80, 95% CI = 1.55 to 5.07) than low PRS (lowest quartile), while adherence to the MDP was high (≥ median), the association disappeared (OR = 1.57, 95% CI = 0.92 to 2.66).
Conclusion
High adherence to the MDP may counteract the genetic predisposition associated with one-carbon metabolism on breast cancer risk in postmenopausal women.</description><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Carbon</subject><subject>Carcinogenesis</subject><subject>Diet</subject><subject>Epidemiology</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic research</subject><subject>Haplotypes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menopause</subject><subject>Metabolism</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Physiological aspects</subject><subject>Post-menopause</subject><subject>Postmenopausal women</subject><subject>Risk factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Womens health</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kstu1TAQhiMEoofCC7BAIyGxIsWOnYuXRxU3qYgNrC3HmSQuiR1sR0fnyfp6uCeFUgkhL2zNfP9YM_Nn2UtKLigh9btASclFTgqak4qSJm8eZTta1iyvC1o_znaEVnVeNaQ6y56FcE0IETURT7MzxkohmqrcZTf7EJw2KhpnA7genMVcK986CzNG1brJhDn3OKmIHQxoERY3HWfnlzFlAhxMHKH1qEIEraxGD96EH6A8wuy6dRO2R-gMxrfQorEDjGYYE3gY0YLq0hOTEKKDOCJ8wc5E9F5ZVPYkU_4Ii4opaMEEmNzhefakV1PAF3f3efb9w_tvl5_yq68fP1_ur3LNaxZzxmuiqS4FKRrkquWiR45t37WCFRyrnlSqq0vWpijnVCusuzSYvhCqZA0r2Xn2equ7ePdzxRDltVu9TV_KouSpKuGiuKcGNaE0tnfRKz2boOW-qqpCpEXdUhf_oNLpcDY6Db43Kf5A8OYvwYhqimNw03pa1kOw2EDtXQgee7l4M6epSUrkrVfk5hWZvCJPXpFNEr26a21tZ-z-SH6bIwFsA0JK2QH9fe__KfsLmSzLxA</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Cao, Shang</creator><creator>Zhu, Zheng</creator><creator>Zhou, Jinyi</creator><creator>Li, Wei</creator><creator>Dong, Yunqiu</creator><creator>Qian, Yun</creator><creator>Wei, Pingmin</creator><creator>Wu, Ming</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-8798-0288</orcidid></search><sort><creationdate>20210601</creationdate><title>Associations of one-carbon metabolism-related gene polymorphisms with breast cancer risk are modulated by diet, being higher when adherence to the Mediterranean dietary pattern is low</title><author>Cao, Shang ; Zhu, Zheng ; Zhou, Jinyi ; Li, Wei ; Dong, Yunqiu ; Qian, Yun ; Wei, Pingmin ; Wu, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-3470c1c59028e4ab49fe4ebfdb9324e6f06ad753be4e441cae7d986f29a538353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Carbon</topic><topic>Carcinogenesis</topic><topic>Diet</topic><topic>Epidemiology</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genetic research</topic><topic>Haplotypes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menopause</topic><topic>Metabolism</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Physiological aspects</topic><topic>Post-menopause</topic><topic>Postmenopausal women</topic><topic>Risk factors</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Shang</creatorcontrib><creatorcontrib>Zhu, Zheng</creatorcontrib><creatorcontrib>Zhou, Jinyi</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Dong, Yunqiu</creatorcontrib><creatorcontrib>Qian, Yun</creatorcontrib><creatorcontrib>Wei, Pingmin</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Shang</au><au>Zhu, Zheng</au><au>Zhou, Jinyi</au><au>Li, Wei</au><au>Dong, Yunqiu</au><au>Qian, Yun</au><au>Wei, Pingmin</au><au>Wu, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of one-carbon metabolism-related gene polymorphisms with breast cancer risk are modulated by diet, being higher when adherence to the Mediterranean dietary pattern is low</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>187</volume><issue>3</issue><spage>793</spage><epage>804</epage><pages>793-804</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><abstract>Purpose
Breast cancer is more likely attributed to a combination of genetic variations and lifestyle factors. Both one-carbon metabolism and diet-related factors could interfere with the carcinogenesis of breast cancer (BC), but whether diet consumed underlie a specific metabolism pathway could influence the impact of genetic variants on breast cancer risk remains equivocal.
Methods
A case–control study of the Chinese female population (818 cases, 935 controls). 13 SNPs in eight one-carbon metabolism-related genes (
MTHFD1
,
TYMS
,
MTRR
,
MAT2B
,
CDO1
,
FOLR1
,
UNG2
,
ADA
) were performed. Diet was assessed by a validated food-frequency questionnaire. We examined the associations of the adherence to the Mediterranean dietary pattern (MDP) and single-nucleotide polymorphisms (SNPs) of one-carbon metabolism with breast cancer risk. We constructed an aggregate polygenic risk score (PRS) to test the additive effects of genetic variants and analyzed the gene–diet interactions.
Results
High adherence (highest quartile) to the MDP decreased the risk of breast cancer among post- but not premenopausal women, respectively (OR = 0.54, 95% CI = 0.38 to 0.78 and 0.90, 0.53 to 1.53). Neither of the polymorphisms or haplotypes was associated with breast cancer risk, irrespective of menopause. However, a high PRS (highest quartile) was associated with more than a doubling risk in both post- and premenopausal women, respectively (OR = 1.95, 95% CI = 1.32 to 2.87 and 2.09, 1.54 to 2.85). We found a gene–diet interaction with adherence to the MDP for aggregate PRS (
P
-interaction = 0.000) among postmenopausal women. When adherence to the MDP was low (< median), carries with high PRS (highest quartile) had higher BC risk (OR = 2.80, 95% CI = 1.55 to 5.07) than low PRS (lowest quartile), while adherence to the MDP was high (≥ median), the association disappeared (OR = 1.57, 95% CI = 0.92 to 2.66).
Conclusion
High adherence to the MDP may counteract the genetic predisposition associated with one-carbon metabolism on breast cancer risk in postmenopausal women.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33599865</pmid><doi>10.1007/s10549-021-06108-8</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8798-0288</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-6806 |
| ispartof | Breast cancer research and treatment, 2021-06, Vol.187 (3), p.793-804 |
| issn | 0167-6806 1573-7217 |
| language | eng |
| recordid | cdi_proquest_journals_2540280492 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Breast cancer Cancer Cancer research Carbon Carcinogenesis Diet Epidemiology Gene polymorphism Genes Genetic aspects Genetic diversity Genetic research Haplotypes Medicine Medicine & Public Health Menopause Metabolism Oncology Oncology, Experimental Physiological aspects Post-menopause Postmenopausal women Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Womens health |
| title | Associations of one-carbon metabolism-related gene polymorphisms with breast cancer risk are modulated by diet, being higher when adherence to the Mediterranean dietary pattern is low |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T01%3A00%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Associations%20of%20one-carbon%20metabolism-related%20gene%20polymorphisms%20with%20breast%20cancer%20risk%20are%20modulated%20by%20diet,%20being%20higher%20when%20adherence%20to%20the%20Mediterranean%20dietary%20pattern%20is%20low&rft.jtitle=Breast%20cancer%20research%20and%20treatment&rft.au=Cao,%20Shang&rft.date=2021-06-01&rft.volume=187&rft.issue=3&rft.spage=793&rft.epage=804&rft.pages=793-804&rft.issn=0167-6806&rft.eissn=1573-7217&rft_id=info:doi/10.1007/s10549-021-06108-8&rft_dat=%3Cgale_proqu%3EA666290542%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2540280492&rft_id=info:pmid/33599865&rft_galeid=A666290542&rfr_iscdi=true |