Directed evolution of glycosyltransferase for enhanced efficiency of avermectin glucosylation

Avermectin, produced by Streptomyces avermitilis , is an active compound protective against nematodes, insects, and mites. However, its potential usage is limited by its low aqueous solubility. The uridine diphosphate (UDP)-glycosyltransferase (BLC) from Bacillus licheniformis synthesizes avermectin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Applied microbiology and biotechnology 2021-06, Vol.105 (11), p.4599-4607
Hauptverfasser:	Choi, Ha-Young, Lim, Hyun Seung, Park, Kwang-Hyun, Kim, Junheon, Kim, Won-Gon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiparasitic agents Avermectin Biomedical and Life Sciences Biotechnologically Relevant Enzymes and Proteins Biotechnology Catalytic activity Chemical properties Chemical reactions Combinatorial analysis Directed evolution Energy value Enzymatic activity Enzyme activity Evolution Free energy Glycosides Glycosylation Glycosyltransferase Glycosyltransferases Insects Life Sciences Mass production Methods Microbial Genetics and Genomics Microbiology Mutagenesis Mutants Mutation Nematodes Physiological aspects Polyketides Site-directed mutagenesis Solubility Substrates Uridine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!