Preparation of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid drug carrier material for cancer treatment and its properties of sustained release mechanism by Korsmeyer–Peppas kinetic model
Cancer is a major threat to human health, and the morbidity is increasing these years for cancer disease; we emphasized to put forward higher requirements for the development of novel pharmaceutic preparations of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid...
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| Veröffentlicht in: | Journal of materials science 2021-09, Vol.56 (25), p.14270-14286 |
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| creator | Ge, Mingliang Li, Yueying Zhu, Caiping Liang, Guodong S.M., Jahangir Alam Hu, Guoqing Gui, Yuee M., Junaebur Rashid |
| description | Cancer is a major threat to human health, and the morbidity is increasing these years for cancer disease; we emphasized to put forward higher requirements for the development of novel pharmaceutic preparations of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid drug carrier material for cancer treatment with high efficiency, sustained releasing and targeted delivery properties. Herein, the nanoparticles Fe
3
O
4
were supported on cetyltrimethyl ammonium-bromide (CTAB)-modified magadiite (CTAB-MAG) by coprecipitation method to prepare magnetic composite particles (CTAB-MAG–Fe
3
O
4
). Compared with the existing drug carriers, the obtained CTAB-MAG–Fe
3
O
4
exhibited high drug loading capacity up to 123.98 mg/g of binding anticancer drug 5-fluorouracil (5-FU), whereas the drug accumulated release ratio was found 55.94% after 48 h. The sustained releasing properties showed that the drug loading and the drug utilization rate of CTAB-MAG–Fe
3
O
4
were significantly improved in the simulated gastric fluid buffer and the simulated intestinal fluid buffer. Therefore, orally taking 1.21–2.41 g of CTAB-MAG–Fe
3
O
4
/5-FU could satisfy the patients’ demand once-per-day. According to sustained releasing kinetics research, the sustained releasing process was conformed to the Korsmeyer–Peppas kinetic model, which was mainly controlled by diffusion process and it belonged to Fickian diffusion model. The prepared drug carrier system combined the advantages of the iron oxide nanoparticles with layered silicate MAG, which will be potential in applications of drug delivery system.
Graphical abstract |
| doi_str_mv | 10.1007/s10853-021-06181-w |
| format | Article |
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3
O
4
were supported on cetyltrimethyl ammonium-bromide (CTAB)-modified magadiite (CTAB-MAG) by coprecipitation method to prepare magnetic composite particles (CTAB-MAG–Fe
3
O
4
). Compared with the existing drug carriers, the obtained CTAB-MAG–Fe
3
O
4
exhibited high drug loading capacity up to 123.98 mg/g of binding anticancer drug 5-fluorouracil (5-FU), whereas the drug accumulated release ratio was found 55.94% after 48 h. The sustained releasing properties showed that the drug loading and the drug utilization rate of CTAB-MAG–Fe
3
O
4
were significantly improved in the simulated gastric fluid buffer and the simulated intestinal fluid buffer. Therefore, orally taking 1.21–2.41 g of CTAB-MAG–Fe
3
O
4
/5-FU could satisfy the patients’ demand once-per-day. According to sustained releasing kinetics research, the sustained releasing process was conformed to the Korsmeyer–Peppas kinetic model, which was mainly controlled by diffusion process and it belonged to Fickian diffusion model. The prepared drug carrier system combined the advantages of the iron oxide nanoparticles with layered silicate MAG, which will be potential in applications of drug delivery system.
Graphical abstract</description><identifier>ISSN: 0022-2461</identifier><identifier>EISSN: 1573-4803</identifier><identifier>DOI: 10.1007/s10853-021-06181-w</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Buffers ; Cancer therapies ; Cetyltrimethylammonium bromide ; Characterization and Evaluation of Materials ; Chemistry and Materials Science ; Classical Mechanics ; Crystallography and Scattering Methods ; Drug carriers ; Drug delivery systems ; Drugs ; Fluorouracil ; Health aspects ; Iron oxides ; Materials for Life Sciences ; Materials Science ; Nanocomposites ; Nanoparticles ; Particulate composites ; Polymer Sciences ; Solid Mechanics ; Sustained release ; Vehicles</subject><ispartof>Journal of materials science, 2021-09, Vol.56 (25), p.14270-14286</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-6bdc7b38562cb2cce5b47876902654b2cbc15e372e6ae7d9fbcc35e290588d493</citedby><cites>FETCH-LOGICAL-c381t-6bdc7b38562cb2cce5b47876902654b2cbc15e372e6ae7d9fbcc35e290588d493</cites><orcidid>0000-0001-6383-4107</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10853-021-06181-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10853-021-06181-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Ge, Mingliang</creatorcontrib><creatorcontrib>Li, Yueying</creatorcontrib><creatorcontrib>Zhu, Caiping</creatorcontrib><creatorcontrib>Liang, Guodong</creatorcontrib><creatorcontrib>S.M., Jahangir Alam</creatorcontrib><creatorcontrib>Hu, Guoqing</creatorcontrib><creatorcontrib>Gui, Yuee</creatorcontrib><creatorcontrib>M., Junaebur Rashid</creatorcontrib><title>Preparation of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid drug carrier material for cancer treatment and its properties of sustained release mechanism by Korsmeyer–Peppas kinetic model</title><title>Journal of materials science</title><addtitle>J Mater Sci</addtitle><description>Cancer is a major threat to human health, and the morbidity is increasing these years for cancer disease; we emphasized to put forward higher requirements for the development of novel pharmaceutic preparations of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid drug carrier material for cancer treatment with high efficiency, sustained releasing and targeted delivery properties. Herein, the nanoparticles Fe
3
O
4
were supported on cetyltrimethyl ammonium-bromide (CTAB)-modified magadiite (CTAB-MAG) by coprecipitation method to prepare magnetic composite particles (CTAB-MAG–Fe
3
O
4
). Compared with the existing drug carriers, the obtained CTAB-MAG–Fe
3
O
4
exhibited high drug loading capacity up to 123.98 mg/g of binding anticancer drug 5-fluorouracil (5-FU), whereas the drug accumulated release ratio was found 55.94% after 48 h. The sustained releasing properties showed that the drug loading and the drug utilization rate of CTAB-MAG–Fe
3
O
4
were significantly improved in the simulated gastric fluid buffer and the simulated intestinal fluid buffer. Therefore, orally taking 1.21–2.41 g of CTAB-MAG–Fe
3
O
4
/5-FU could satisfy the patients’ demand once-per-day. According to sustained releasing kinetics research, the sustained releasing process was conformed to the Korsmeyer–Peppas kinetic model, which was mainly controlled by diffusion process and it belonged to Fickian diffusion model. The prepared drug carrier system combined the advantages of the iron oxide nanoparticles with layered silicate MAG, which will be potential in applications of drug delivery system.
Graphical abstract</description><subject>Analysis</subject><subject>Buffers</subject><subject>Cancer therapies</subject><subject>Cetyltrimethylammonium bromide</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Classical Mechanics</subject><subject>Crystallography and Scattering Methods</subject><subject>Drug carriers</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Fluorouracil</subject><subject>Health aspects</subject><subject>Iron oxides</subject><subject>Materials for Life Sciences</subject><subject>Materials Science</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>Particulate composites</subject><subject>Polymer Sciences</subject><subject>Solid Mechanics</subject><subject>Sustained release</subject><subject>Vehicles</subject><issn>0022-2461</issn><issn>1573-4803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9ks1u1TAQhSMEEpfCC7CyxIpFqO3EibOsKn6qVqLiZ205ziR1Seww9qXcHe_AG7LiMRgapKobpEiOjs8cf7ZOUTwX_JXgvD1OgmtVlVyKkjdCi_LmQbETqq3KWvPqYbHjXMpS1o14XDxJ6ZpzrlopdsXvS4TVos0-BhZHFnGywbtyiYMfPQxssZMdvM_w68dP-g-QvWPBhujissZEG4zmSZwhMUtfYDCO4LL_Bre-q0OPfmAD7ifmLKIHpNAM6O3MxogkBkdaRrB5gZApYmA-J7ZiXIGiKZjI0j5l6wMhIcxgE7AF3BXBpoX1B3YeMS1wACTOS1hXQvniN1q6C8xPi0ejnRM8-7ceFZ_fvP50-q68eP_27PTkonSVFrls-sG1faVVI10vnQPV161um47LRtWk9E4oqFoJjYV26MbeuUqB7LjSeqi76qh4seUS_dc9pGyu4x4DHWmkqundtdD1nWuyMxgfxpjRusUnZ06appGdULol18t7LhdDhu95svuUzNnHD_e9cvM6jCkhjGZFv1g8GMHN346YrSOGOmJuO2JuaKjahhKZwwR4B_ufqT_u2Mef</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Ge, Mingliang</creator><creator>Li, Yueying</creator><creator>Zhu, Caiping</creator><creator>Liang, Guodong</creator><creator>S.M., Jahangir Alam</creator><creator>Hu, Guoqing</creator><creator>Gui, Yuee</creator><creator>M., Junaebur Rashid</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><orcidid>https://orcid.org/0000-0001-6383-4107</orcidid></search><sort><creationdate>20210901</creationdate><title>Preparation of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid drug carrier material for cancer treatment and its properties of sustained release mechanism by Korsmeyer–Peppas kinetic model</title><author>Ge, Mingliang ; Li, Yueying ; Zhu, Caiping ; Liang, Guodong ; S.M., Jahangir Alam ; Hu, Guoqing ; Gui, Yuee ; M., Junaebur Rashid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-6bdc7b38562cb2cce5b47876902654b2cbc15e372e6ae7d9fbcc35e290588d493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Buffers</topic><topic>Cancer therapies</topic><topic>Cetyltrimethylammonium bromide</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry and Materials Science</topic><topic>Classical Mechanics</topic><topic>Crystallography and Scattering Methods</topic><topic>Drug carriers</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Fluorouracil</topic><topic>Health aspects</topic><topic>Iron oxides</topic><topic>Materials for Life Sciences</topic><topic>Materials Science</topic><topic>Nanocomposites</topic><topic>Nanoparticles</topic><topic>Particulate composites</topic><topic>Polymer Sciences</topic><topic>Solid Mechanics</topic><topic>Sustained release</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ge, Mingliang</creatorcontrib><creatorcontrib>Li, Yueying</creatorcontrib><creatorcontrib>Zhu, Caiping</creatorcontrib><creatorcontrib>Liang, Guodong</creatorcontrib><creatorcontrib>S.M., Jahangir Alam</creatorcontrib><creatorcontrib>Hu, Guoqing</creatorcontrib><creatorcontrib>Gui, Yuee</creatorcontrib><creatorcontrib>M., Junaebur Rashid</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><jtitle>Journal of materials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ge, Mingliang</au><au>Li, Yueying</au><au>Zhu, Caiping</au><au>Liang, Guodong</au><au>S.M., Jahangir Alam</au><au>Hu, Guoqing</au><au>Gui, Yuee</au><au>M., Junaebur Rashid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid drug carrier material for cancer treatment and its properties of sustained release mechanism by Korsmeyer–Peppas kinetic model</atitle><jtitle>Journal of materials science</jtitle><stitle>J Mater Sci</stitle><date>2021-09-01</date><risdate>2021</risdate><volume>56</volume><issue>25</issue><spage>14270</spage><epage>14286</epage><pages>14270-14286</pages><issn>0022-2461</issn><eissn>1573-4803</eissn><abstract>Cancer is a major threat to human health, and the morbidity is increasing these years for cancer disease; we emphasized to put forward higher requirements for the development of novel pharmaceutic preparations of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid drug carrier material for cancer treatment with high efficiency, sustained releasing and targeted delivery properties. Herein, the nanoparticles Fe
3
O
4
were supported on cetyltrimethyl ammonium-bromide (CTAB)-modified magadiite (CTAB-MAG) by coprecipitation method to prepare magnetic composite particles (CTAB-MAG–Fe
3
O
4
). Compared with the existing drug carriers, the obtained CTAB-MAG–Fe
3
O
4
exhibited high drug loading capacity up to 123.98 mg/g of binding anticancer drug 5-fluorouracil (5-FU), whereas the drug accumulated release ratio was found 55.94% after 48 h. The sustained releasing properties showed that the drug loading and the drug utilization rate of CTAB-MAG–Fe
3
O
4
were significantly improved in the simulated gastric fluid buffer and the simulated intestinal fluid buffer. Therefore, orally taking 1.21–2.41 g of CTAB-MAG–Fe
3
O
4
/5-FU could satisfy the patients’ demand once-per-day. According to sustained releasing kinetics research, the sustained releasing process was conformed to the Korsmeyer–Peppas kinetic model, which was mainly controlled by diffusion process and it belonged to Fickian diffusion model. The prepared drug carrier system combined the advantages of the iron oxide nanoparticles with layered silicate MAG, which will be potential in applications of drug delivery system.
Graphical abstract</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10853-021-06181-w</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-6383-4107</orcidid></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Analysis Buffers Cancer therapies Cetyltrimethylammonium bromide Characterization and Evaluation of Materials Chemistry and Materials Science Classical Mechanics Crystallography and Scattering Methods Drug carriers Drug delivery systems Drugs Fluorouracil Health aspects Iron oxides Materials for Life Sciences Materials Science Nanocomposites Nanoparticles Particulate composites Polymer Sciences Solid Mechanics Sustained release Vehicles |
| title | Preparation of organic-modified magadiite–magnetic nanocomposite particles as an effective nanohybrid drug carrier material for cancer treatment and its properties of sustained release mechanism by Korsmeyer–Peppas kinetic model |
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