The effects of astragalus polysaccharides on the growth, heat stress tolerance and related gene expression of the leech Whitmania pigra
Whitmania pigra is an aquatic annelid with broad pharmacological effects and is widely used for treatment of cardiovascular diseases in Asia. One of the main factors limiting its commercial production is its weak heat stress tolerance. To assess the effects of astragalus polysaccharide (APS) on the...
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| Veröffentlicht in: | Aquaculture research 2021-07, Vol.52 (7), p.3247-3255 |
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| creator | Shi, Hong‐zhuan Wu, Bing Shi, Guo‐wei Zhu, Zai‐biao |
| description | Whitmania pigra is an aquatic annelid with broad pharmacological effects and is widely used for treatment of cardiovascular diseases in Asia. One of the main factors limiting its commercial production is its weak heat stress tolerance. To assess the effects of astragalus polysaccharide (APS) on the growth and heat stress tolerance of W. pigra and the underlying mechanisms, six APS concentration treatments (0‰, 0.01‰, 0.03‰, 0.05‰, 0.07‰ and 0.09‰) were formulated to explore their influence on growth, digestive enzymes and the expression of immune‐ and growth‐related genes at 26°C or 35°C. The results showed that APS significantly enhanced the final weight, weight gain rate, specific growth rate, digestive enzyme and anti‐reverse enzyme activity, and the relative expression level of growth hormone, insulin‐like growth factor‐1 and digestive enzyme‐related genes. The 0.07‰ APS group showed significantly greater values than the other groups (p |
| doi_str_mv | 10.1111/are.15170 |
| format | Article |
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One of the main factors limiting its commercial production is its weak heat stress tolerance. To assess the effects of astragalus polysaccharide (APS) on the growth and heat stress tolerance of W. pigra and the underlying mechanisms, six APS concentration treatments (0‰, 0.01‰, 0.03‰, 0.05‰, 0.07‰ and 0.09‰) were formulated to explore their influence on growth, digestive enzymes and the expression of immune‐ and growth‐related genes at 26°C or 35°C. The results showed that APS significantly enhanced the final weight, weight gain rate, specific growth rate, digestive enzyme and anti‐reverse enzyme activity, and the relative expression level of growth hormone, insulin‐like growth factor‐1 and digestive enzyme‐related genes. The 0.07‰ APS group showed significantly greater values than the other groups (p < 0.05). APS up‐regulated the relative expression of HSP70 and immune‐related genes under heat stress, and the 0.07‰ group showed the greatest modulatory effect. Overall, APS can promote growth, immunity and heat stress resistance in W. pigra, and the recommendation dietary APS level was 0.07‰.</description><identifier>ISSN: 1355-557X</identifier><identifier>EISSN: 1365-2109</identifier><identifier>DOI: 10.1111/are.15170</identifier><language>eng</language><publisher>Oxford: Hindawi Limited</publisher><subject>anti‐reverse enzyme ; Body weight gain ; Cardiovascular diseases ; Digestive enzymes ; Enzymatic activity ; Enzyme activity ; Enzymes ; Gene expression ; Genes ; Growth factors ; Growth hormones ; growth performance ; Growth rate ; Heat ; Heat stress ; Heat tolerance ; Hormones ; Hsp70 protein ; Immunity ; Immunological tolerance ; Insulin ; nonspecific immunity ; Polysaccharides ; Saccharides ; Weight gain ; Whitmania pigra</subject><ispartof>Aquaculture research, 2021-07, Vol.52 (7), p.3247-3255</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3320-bf026ca2ceaa78e4dd1a11a17470741fba6fdc1d5407e001befab27f5906b4773</citedby><cites>FETCH-LOGICAL-c3320-bf026ca2ceaa78e4dd1a11a17470741fba6fdc1d5407e001befab27f5906b4773</cites><orcidid>0000-0002-3925-4767</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fare.15170$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fare.15170$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Shi, Hong‐zhuan</creatorcontrib><creatorcontrib>Wu, Bing</creatorcontrib><creatorcontrib>Shi, Guo‐wei</creatorcontrib><creatorcontrib>Zhu, Zai‐biao</creatorcontrib><title>The effects of astragalus polysaccharides on the growth, heat stress tolerance and related gene expression of the leech Whitmania pigra</title><title>Aquaculture research</title><description>Whitmania pigra is an aquatic annelid with broad pharmacological effects and is widely used for treatment of cardiovascular diseases in Asia. One of the main factors limiting its commercial production is its weak heat stress tolerance. To assess the effects of astragalus polysaccharide (APS) on the growth and heat stress tolerance of W. pigra and the underlying mechanisms, six APS concentration treatments (0‰, 0.01‰, 0.03‰, 0.05‰, 0.07‰ and 0.09‰) were formulated to explore their influence on growth, digestive enzymes and the expression of immune‐ and growth‐related genes at 26°C or 35°C. The results showed that APS significantly enhanced the final weight, weight gain rate, specific growth rate, digestive enzyme and anti‐reverse enzyme activity, and the relative expression level of growth hormone, insulin‐like growth factor‐1 and digestive enzyme‐related genes. The 0.07‰ APS group showed significantly greater values than the other groups (p < 0.05). APS up‐regulated the relative expression of HSP70 and immune‐related genes under heat stress, and the 0.07‰ group showed the greatest modulatory effect. Overall, APS can promote growth, immunity and heat stress resistance in W. pigra, and the recommendation dietary APS level was 0.07‰.</description><subject>anti‐reverse enzyme</subject><subject>Body weight gain</subject><subject>Cardiovascular diseases</subject><subject>Digestive enzymes</subject><subject>Enzymatic activity</subject><subject>Enzyme activity</subject><subject>Enzymes</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Growth factors</subject><subject>Growth hormones</subject><subject>growth performance</subject><subject>Growth rate</subject><subject>Heat</subject><subject>Heat stress</subject><subject>Heat tolerance</subject><subject>Hormones</subject><subject>Hsp70 protein</subject><subject>Immunity</subject><subject>Immunological tolerance</subject><subject>Insulin</subject><subject>nonspecific immunity</subject><subject>Polysaccharides</subject><subject>Saccharides</subject><subject>Weight gain</subject><subject>Whitmania pigra</subject><issn>1355-557X</issn><issn>1365-2109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kN9LwzAQx4MoOKcP_gcBnwS7JW3TbI9jzB8gCDLRt3BNL21H19YkY-4v8N82db56HNzBfe573JeQa84mPMQULE644JKdkBFPMhHFnM1Ph16ISAj5cU4unNswxlOW8BH5XldI0RjU3tHOUHDeQgnNztG-aw4OtK7A1gWGaUt9gEvb7X11RysETwONzlHfNWih1UihLajFBjwWtMQ2aH_1A1KH7SA_CDSIuqLvVe230NZA-7q0cEnODDQOr_7qmLzdr9bLx-j55eFpuXiOdJLELMoNizMNsUYAOcO0KDjwkDKVTKbc5JCZQvNCpExieDJHA3ksjZizLE-lTMbk5qjb2-5zh86rTbezbTipYpHM01nCZjxQt0dK2845i0b1tt6CPSjO1OCzCj6rX58DOz2y-7rBw_-gWryujhs_3gWBbA</recordid><startdate>202107</startdate><enddate>202107</enddate><creator>Shi, Hong‐zhuan</creator><creator>Wu, Bing</creator><creator>Shi, Guo‐wei</creator><creator>Zhu, Zai‐biao</creator><general>Hindawi Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TN</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-3925-4767</orcidid></search><sort><creationdate>202107</creationdate><title>The effects of astragalus polysaccharides on the growth, heat stress tolerance and related gene expression of the leech Whitmania pigra</title><author>Shi, Hong‐zhuan ; Wu, Bing ; Shi, Guo‐wei ; Zhu, Zai‐biao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3320-bf026ca2ceaa78e4dd1a11a17470741fba6fdc1d5407e001befab27f5906b4773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>anti‐reverse enzyme</topic><topic>Body weight gain</topic><topic>Cardiovascular diseases</topic><topic>Digestive enzymes</topic><topic>Enzymatic activity</topic><topic>Enzyme activity</topic><topic>Enzymes</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Growth factors</topic><topic>Growth hormones</topic><topic>growth performance</topic><topic>Growth rate</topic><topic>Heat</topic><topic>Heat stress</topic><topic>Heat tolerance</topic><topic>Hormones</topic><topic>Hsp70 protein</topic><topic>Immunity</topic><topic>Immunological tolerance</topic><topic>Insulin</topic><topic>nonspecific immunity</topic><topic>Polysaccharides</topic><topic>Saccharides</topic><topic>Weight gain</topic><topic>Whitmania pigra</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Hong‐zhuan</creatorcontrib><creatorcontrib>Wu, Bing</creatorcontrib><creatorcontrib>Shi, Guo‐wei</creatorcontrib><creatorcontrib>Zhu, Zai‐biao</creatorcontrib><collection>CrossRef</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Aquaculture research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Hong‐zhuan</au><au>Wu, Bing</au><au>Shi, Guo‐wei</au><au>Zhu, Zai‐biao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of astragalus polysaccharides on the growth, heat stress tolerance and related gene expression of the leech Whitmania pigra</atitle><jtitle>Aquaculture research</jtitle><date>2021-07</date><risdate>2021</risdate><volume>52</volume><issue>7</issue><spage>3247</spage><epage>3255</epage><pages>3247-3255</pages><issn>1355-557X</issn><eissn>1365-2109</eissn><abstract>Whitmania pigra is an aquatic annelid with broad pharmacological effects and is widely used for treatment of cardiovascular diseases in Asia. One of the main factors limiting its commercial production is its weak heat stress tolerance. To assess the effects of astragalus polysaccharide (APS) on the growth and heat stress tolerance of W. pigra and the underlying mechanisms, six APS concentration treatments (0‰, 0.01‰, 0.03‰, 0.05‰, 0.07‰ and 0.09‰) were formulated to explore their influence on growth, digestive enzymes and the expression of immune‐ and growth‐related genes at 26°C or 35°C. The results showed that APS significantly enhanced the final weight, weight gain rate, specific growth rate, digestive enzyme and anti‐reverse enzyme activity, and the relative expression level of growth hormone, insulin‐like growth factor‐1 and digestive enzyme‐related genes. The 0.07‰ APS group showed significantly greater values than the other groups (p < 0.05). APS up‐regulated the relative expression of HSP70 and immune‐related genes under heat stress, and the 0.07‰ group showed the greatest modulatory effect. Overall, APS can promote growth, immunity and heat stress resistance in W. pigra, and the recommendation dietary APS level was 0.07‰.</abstract><cop>Oxford</cop><pub>Hindawi Limited</pub><doi>10.1111/are.15170</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3925-4767</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | anti‐reverse enzyme Body weight gain Cardiovascular diseases Digestive enzymes Enzymatic activity Enzyme activity Enzymes Gene expression Genes Growth factors Growth hormones growth performance Growth rate Heat Heat stress Heat tolerance Hormones Hsp70 protein Immunity Immunological tolerance Insulin nonspecific immunity Polysaccharides Saccharides Weight gain Whitmania pigra |
| title | The effects of astragalus polysaccharides on the growth, heat stress tolerance and related gene expression of the leech Whitmania pigra |
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