A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern
Background/Objectives Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome...
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| Veröffentlicht in: | European journal of clinical nutrition 2021-06, Vol.75 (6), p.937-945 |
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| container_title | European journal of clinical nutrition |
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| creator | Suzuki, Harumitsu Nakamura, Yasuyuki Matsuo, Keitaro Imaeda, Nahomi Goto, Chiho Narita, Akira Shimizu, Atsushi Takashima, Naoyuki Matsui, Kenji Miura, Katsuyuki Nakatochi, Masahiro Hishida, Asahi Tamura, Takashi Kadomatsu, Yuka Okada, Rieko Nishida, Yuichiro Shimanoe, Chisato Nishimoto, Daisaku Takezaki, Toshiro Oze, Isao Ito, Hidemi Ikezaki, Hiroaki Murata, Masayuki Matsui, Daisuke Ozaki, Etsuko Mikami, Haruo Nakamura, Yohko Suzuki, Sadao Watanabe, Miki Arisawa, Kokichi Uemura, Hirokazu Kuriki, Kiyonori Momozawa, Yukihide Kubo, Michiaki Kita, Yoshikuni Takeuchi, Kenji Wakai, Kenji |
| description | Background/Objectives
Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern.
Subjects/Methods
We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region.
Results
We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with
P
values |
| doi_str_mv | 10.1038/s41430-020-00823-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2539398939</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A664721999</galeid><sourcerecordid>A664721999</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-24456b425f8171192700ad6c02d96de399d1d29887300d33fc8871ee75b65d503</originalsourceid><addsrcrecordid>eNp9kltrVDEUhYMoOFb_gE8BwbfU3M4lj0PxSsEXfQ5pss9MypnkmGQs7YO_3T2OtBYGCSFh51s7ZGUR8lrwc8HV-K5qoRVnXOLko1Ts7glZCT30rOs1f0pW3HSaKc6H5-RFrdec4-EgV-TXmm4g5R2wmxiAulqzj67FnGht-3BLY6Jf3OISVKBIpBanCIHmBPSnK9Gldi_C8k1sW-roUmCCAskDnXLBwn2LEKG5cksX1xqU9JI8m9xc4dXf9Yx8__D-28Undvn14-eL9SXzehwbk1p3_ZWW3TSKQQgjB85d6D2XwfQBlDFBBGnGccAnBqUmj1sBMHRXfRc6rs7Im2PfpeQfe6jNXud9SXillZ0yyow4H6iNm8HGNOVWnN_F6u267_UghTEHip2g0EUobkZfpojlR_z5CR5HgF30JwVv_xFswc1tW_O8P_xKfQzKI-hLrhU9t0uJO7TXCm4PubDHXFjMhf2TC3uHInUUVYTTBsqDFf9R_QYmDLld</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2539398939</pqid></control><display><type>article</type><title>A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern</title><source>SpringerLink Journals - AutoHoldings</source><creator>Suzuki, Harumitsu ; Nakamura, Yasuyuki ; Matsuo, Keitaro ; Imaeda, Nahomi ; Goto, Chiho ; Narita, Akira ; Shimizu, Atsushi ; Takashima, Naoyuki ; Matsui, Kenji ; Miura, Katsuyuki ; Nakatochi, Masahiro ; Hishida, Asahi ; Tamura, Takashi ; Kadomatsu, Yuka ; Okada, Rieko ; Nishida, Yuichiro ; Shimanoe, Chisato ; Nishimoto, Daisaku ; Takezaki, Toshiro ; Oze, Isao ; Ito, Hidemi ; Ikezaki, Hiroaki ; Murata, Masayuki ; Matsui, Daisuke ; Ozaki, Etsuko ; Mikami, Haruo ; Nakamura, Yohko ; Suzuki, Sadao ; Watanabe, Miki ; Arisawa, Kokichi ; Uemura, Hirokazu ; Kuriki, Kiyonori ; Momozawa, Yukihide ; Kubo, Michiaki ; Kita, Yoshikuni ; Takeuchi, Kenji ; Wakai, Kenji</creator><creatorcontrib>Suzuki, Harumitsu ; Nakamura, Yasuyuki ; Matsuo, Keitaro ; Imaeda, Nahomi ; Goto, Chiho ; Narita, Akira ; Shimizu, Atsushi ; Takashima, Naoyuki ; Matsui, Kenji ; Miura, Katsuyuki ; Nakatochi, Masahiro ; Hishida, Asahi ; Tamura, Takashi ; Kadomatsu, Yuka ; Okada, Rieko ; Nishida, Yuichiro ; Shimanoe, Chisato ; Nishimoto, Daisaku ; Takezaki, Toshiro ; Oze, Isao ; Ito, Hidemi ; Ikezaki, Hiroaki ; Murata, Masayuki ; Matsui, Daisuke ; Ozaki, Etsuko ; Mikami, Haruo ; Nakamura, Yohko ; Suzuki, Sadao ; Watanabe, Miki ; Arisawa, Kokichi ; Uemura, Hirokazu ; Kuriki, Kiyonori ; Momozawa, Yukihide ; Kubo, Michiaki ; Kita, Yoshikuni ; Takeuchi, Kenji ; Wakai, Kenji</creatorcontrib><description>Background/Objectives
Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern.
Subjects/Methods
We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region.
Results
We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with
P
values <5 × 10
−8
. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity.
Conclusion
We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-020-00823-z</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/43 ; 692/308/174 ; 692/700/2814 ; Annotations ; Cardiovascular diseases ; Chromosome 14 ; Clinical Nutrition ; Eating behavior ; Energy intake ; Environmental factors ; Epidemiology ; Food ; Food groups ; Food habits ; Gene expression ; Genes ; Genetic aspects ; Genetic diversity ; Genetic factors ; Genetic research ; Genetic variation ; Genome-wide association studies ; Genomes ; Histocompatibility ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Obesity ; Olfaction ; Pattern analysis ; Population genetics ; Public Health ; Regression analysis ; Single-nucleotide polymorphism</subject><ispartof>European journal of clinical nutrition, 2021-06, Vol.75 (6), p.937-945</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-24456b425f8171192700ad6c02d96de399d1d29887300d33fc8871ee75b65d503</citedby><cites>FETCH-LOGICAL-c488t-24456b425f8171192700ad6c02d96de399d1d29887300d33fc8871ee75b65d503</cites><orcidid>0000-0003-1761-6314 ; 0000-0002-9593-6797 ; 0000-0002-3710-5258 ; 0000-0003-2320-7234 ; 0000-0002-8023-4581 ; 0000-0002-6677-6341 ; 0000-0002-0762-1147 ; 0000-0002-0443-4266 ; 0000-0003-3106-3488 ; 0000-0002-6206-2501 ; 0000-0002-6397-6129</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41430-020-00823-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41430-020-00823-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Suzuki, Harumitsu</creatorcontrib><creatorcontrib>Nakamura, Yasuyuki</creatorcontrib><creatorcontrib>Matsuo, Keitaro</creatorcontrib><creatorcontrib>Imaeda, Nahomi</creatorcontrib><creatorcontrib>Goto, Chiho</creatorcontrib><creatorcontrib>Narita, Akira</creatorcontrib><creatorcontrib>Shimizu, Atsushi</creatorcontrib><creatorcontrib>Takashima, Naoyuki</creatorcontrib><creatorcontrib>Matsui, Kenji</creatorcontrib><creatorcontrib>Miura, Katsuyuki</creatorcontrib><creatorcontrib>Nakatochi, Masahiro</creatorcontrib><creatorcontrib>Hishida, Asahi</creatorcontrib><creatorcontrib>Tamura, Takashi</creatorcontrib><creatorcontrib>Kadomatsu, Yuka</creatorcontrib><creatorcontrib>Okada, Rieko</creatorcontrib><creatorcontrib>Nishida, Yuichiro</creatorcontrib><creatorcontrib>Shimanoe, Chisato</creatorcontrib><creatorcontrib>Nishimoto, Daisaku</creatorcontrib><creatorcontrib>Takezaki, Toshiro</creatorcontrib><creatorcontrib>Oze, Isao</creatorcontrib><creatorcontrib>Ito, Hidemi</creatorcontrib><creatorcontrib>Ikezaki, Hiroaki</creatorcontrib><creatorcontrib>Murata, Masayuki</creatorcontrib><creatorcontrib>Matsui, Daisuke</creatorcontrib><creatorcontrib>Ozaki, Etsuko</creatorcontrib><creatorcontrib>Mikami, Haruo</creatorcontrib><creatorcontrib>Nakamura, Yohko</creatorcontrib><creatorcontrib>Suzuki, Sadao</creatorcontrib><creatorcontrib>Watanabe, Miki</creatorcontrib><creatorcontrib>Arisawa, Kokichi</creatorcontrib><creatorcontrib>Uemura, Hirokazu</creatorcontrib><creatorcontrib>Kuriki, Kiyonori</creatorcontrib><creatorcontrib>Momozawa, Yukihide</creatorcontrib><creatorcontrib>Kubo, Michiaki</creatorcontrib><creatorcontrib>Kita, Yoshikuni</creatorcontrib><creatorcontrib>Takeuchi, Kenji</creatorcontrib><creatorcontrib>Wakai, Kenji</creatorcontrib><title>A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives
Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern.
Subjects/Methods
We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region.
Results
We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with
P
values <5 × 10
−8
. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity.
Conclusion
We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.</description><subject>45</subject><subject>45/43</subject><subject>692/308/174</subject><subject>692/700/2814</subject><subject>Annotations</subject><subject>Cardiovascular diseases</subject><subject>Chromosome 14</subject><subject>Clinical Nutrition</subject><subject>Eating behavior</subject><subject>Energy intake</subject><subject>Environmental factors</subject><subject>Epidemiology</subject><subject>Food</subject><subject>Food groups</subject><subject>Food habits</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic factors</subject><subject>Genetic research</subject><subject>Genetic variation</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>Histocompatibility</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Obesity</subject><subject>Olfaction</subject><subject>Pattern analysis</subject><subject>Population genetics</subject><subject>Public Health</subject><subject>Regression analysis</subject><subject>Single-nucleotide 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Nahomi</creator><creator>Goto, Chiho</creator><creator>Narita, Akira</creator><creator>Shimizu, Atsushi</creator><creator>Takashima, Naoyuki</creator><creator>Matsui, Kenji</creator><creator>Miura, Katsuyuki</creator><creator>Nakatochi, Masahiro</creator><creator>Hishida, Asahi</creator><creator>Tamura, Takashi</creator><creator>Kadomatsu, Yuka</creator><creator>Okada, Rieko</creator><creator>Nishida, Yuichiro</creator><creator>Shimanoe, Chisato</creator><creator>Nishimoto, Daisaku</creator><creator>Takezaki, Toshiro</creator><creator>Oze, Isao</creator><creator>Ito, Hidemi</creator><creator>Ikezaki, Hiroaki</creator><creator>Murata, Masayuki</creator><creator>Matsui, Daisuke</creator><creator>Ozaki, Etsuko</creator><creator>Mikami, Haruo</creator><creator>Nakamura, Yohko</creator><creator>Suzuki, Sadao</creator><creator>Watanabe, Miki</creator><creator>Arisawa, Kokichi</creator><creator>Uemura, Hirokazu</creator><creator>Kuriki, Kiyonori</creator><creator>Momozawa, 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genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern</title><author>Suzuki, Harumitsu ; Nakamura, Yasuyuki ; Matsuo, Keitaro ; Imaeda, Nahomi ; Goto, Chiho ; Narita, Akira ; Shimizu, Atsushi ; Takashima, Naoyuki ; Matsui, Kenji ; Miura, Katsuyuki ; Nakatochi, Masahiro ; Hishida, Asahi ; Tamura, Takashi ; Kadomatsu, Yuka ; Okada, Rieko ; Nishida, Yuichiro ; Shimanoe, Chisato ; Nishimoto, Daisaku ; Takezaki, Toshiro ; Oze, Isao ; Ito, Hidemi ; Ikezaki, Hiroaki ; Murata, Masayuki ; Matsui, Daisuke ; Ozaki, Etsuko ; Mikami, Haruo ; Nakamura, Yohko ; Suzuki, Sadao ; Watanabe, Miki ; Arisawa, Kokichi ; Uemura, Hirokazu ; Kuriki, Kiyonori ; Momozawa, Yukihide ; Kubo, Michiaki ; Kita, Yoshikuni ; Takeuchi, Kenji ; Wakai, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-24456b425f8171192700ad6c02d96de399d1d29887300d33fc8871ee75b65d503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>45</topic><topic>45/43</topic><topic>692/308/174</topic><topic>692/700/2814</topic><topic>Annotations</topic><topic>Cardiovascular diseases</topic><topic>Chromosome 14</topic><topic>Clinical Nutrition</topic><topic>Eating behavior</topic><topic>Energy intake</topic><topic>Environmental factors</topic><topic>Epidemiology</topic><topic>Food</topic><topic>Food groups</topic><topic>Food habits</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genetic factors</topic><topic>Genetic research</topic><topic>Genetic variation</topic><topic>Genome-wide association 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Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Harumitsu</au><au>Nakamura, Yasuyuki</au><au>Matsuo, Keitaro</au><au>Imaeda, Nahomi</au><au>Goto, Chiho</au><au>Narita, Akira</au><au>Shimizu, Atsushi</au><au>Takashima, Naoyuki</au><au>Matsui, Kenji</au><au>Miura, Katsuyuki</au><au>Nakatochi, Masahiro</au><au>Hishida, Asahi</au><au>Tamura, Takashi</au><au>Kadomatsu, Yuka</au><au>Okada, Rieko</au><au>Nishida, Yuichiro</au><au>Shimanoe, Chisato</au><au>Nishimoto, Daisaku</au><au>Takezaki, Toshiro</au><au>Oze, Isao</au><au>Ito, Hidemi</au><au>Ikezaki, Hiroaki</au><au>Murata, Masayuki</au><au>Matsui, Daisuke</au><au>Ozaki, Etsuko</au><au>Mikami, Haruo</au><au>Nakamura, Yohko</au><au>Suzuki, Sadao</au><au>Watanabe, Miki</au><au>Arisawa, Kokichi</au><au>Uemura, Hirokazu</au><au>Kuriki, Kiyonori</au><au>Momozawa, Yukihide</au><au>Kubo, Michiaki</au><au>Kita, Yoshikuni</au><au>Takeuchi, Kenji</au><au>Wakai, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><date>2021-06-01</date><risdate>2021</risdate><volume>75</volume><issue>6</issue><spage>937</spage><epage>945</epage><pages>937-945</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/Objectives
Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern.
Subjects/Methods
We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region.
Results
We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with
P
values <5 × 10
−8
. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity.
Conclusion
We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/s41430-020-00823-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1761-6314</orcidid><orcidid>https://orcid.org/0000-0002-9593-6797</orcidid><orcidid>https://orcid.org/0000-0002-3710-5258</orcidid><orcidid>https://orcid.org/0000-0003-2320-7234</orcidid><orcidid>https://orcid.org/0000-0002-8023-4581</orcidid><orcidid>https://orcid.org/0000-0002-6677-6341</orcidid><orcidid>https://orcid.org/0000-0002-0762-1147</orcidid><orcidid>https://orcid.org/0000-0002-0443-4266</orcidid><orcidid>https://orcid.org/0000-0003-3106-3488</orcidid><orcidid>https://orcid.org/0000-0002-6206-2501</orcidid><orcidid>https://orcid.org/0000-0002-6397-6129</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2021-06, Vol.75 (6), p.937-945 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_journals_2539398939 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | 45 45/43 692/308/174 692/700/2814 Annotations Cardiovascular diseases Chromosome 14 Clinical Nutrition Eating behavior Energy intake Environmental factors Epidemiology Food Food groups Food habits Gene expression Genes Genetic aspects Genetic diversity Genetic factors Genetic research Genetic variation Genome-wide association studies Genomes Histocompatibility Internal Medicine Medicine Medicine & Public Health Metabolic Diseases Obesity Olfaction Pattern analysis Population genetics Public Health Regression analysis Single-nucleotide polymorphism |
| title | A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern |
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