Association between the anticancer efficacy of cabazitaxel and toll-like receptor 4 mediating signaling pathways in metastatic castration-resistant prostate cancer cells

Background: We evaluated the effect of cabazitaxel (CAB) as a third-line taxane on Toll-like receptor 4 (TLR4)-mediated signaling pathways, especially NF-κB activity, in metastatic castration-resistant prostate cancer (mCRPC) cells. Methods: CAB cytotoxicity was determined by WST-1 assay. To assess...

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Veröffentlicht in:	Human & experimental toxicology 2021-07, Vol.40 (7), p.1122-1129
Hauptverfasser:	Guney Eskiler, Gamze, Ozkan, Asuman Deveci, Eryilmaz, Isil Ezgi, Egeli, Unal, Cecener, Gulsah
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Anticancer properties Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects BAX protein Caspase-3 Castration Cell death Cell Survival - drug effects Cells, Cultured - drug effects Chemotherapy Cytotoxicity Humans Immunofluorescence Interferon regulatory factor 3 Localization Male Metastases Metastasis NF-κB protein p53 Protein Polymerase chain reaction Prostate cancer Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - physiopathology Receptors Signal transduction Signal Transduction - drug effects Signaling Taxoids - therapeutic use Taxoids - toxicity TLR4 protein Toll-Like Receptor 4 - therapeutic use Toll-like receptors Toxicity Treatment Outcome
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