Novel podophyllotoxin and benzothiazole derivative induces transitional morphological and functional changes in HaCaT cells

Podophyllotoxin (PPT) is an antimitotic drug used topically in the treatment of anogenital warts. Due to its toxicity it cannot be administered systemically as an anticancer agent. However, modified PPT derivatives such as etoposide and teniposide are used clinically as systemic agents. Thus, we inv...

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Veröffentlicht in:	Toxicology in vitro 2021-06, Vol.73, p.105144, Article 105144
Hauptverfasser:	Strus, Piotr, Borensztejn, Karol, Szczepankiewicz, Andrzej Antoni, Lisiecki, Kamil, Czarnocki, Zbigniew, Nieznanska, Hanna, Wojcik, Cezary, Bialy, Lukasz P., Mlynarczuk-Bialy, Izabela
Format:	Artikel
Sprache:	eng
Schlagworte:	Anogenital Anticancer properties Antitumor agents Apoptosis Apoptotic caspase 9 Autophagy Benzothiazole Cancer Cell cycle Cell death Cell membranes Disintegration Elongation Etoposide HaCaT ultrastructure in TEM Homeostasis Keratinocytes Leukocytes (mononuclear) Mitochondria Necrosis Peripheral blood mononuclear cells Phagocytosis Podophyllotoxin Teniposide Toxicity Warts
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