Study of Antimicrobial Properties of Preparations Based on Maleic-Acid Copolymers Containing Silver Nanoparticles and Phenolic Residues
In this work, water-soluble polymer composites containing two antimicrobial components, silver nanoparticles and phenol ligands, are obtained. The maleic-acid groups of the used matrix, a copolymer of maleic acid with ethylene, contributed to the production of noncovalent polymer conjugates of p-ami...
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| Veröffentlicht in: | Applied biochemistry and microbiology 2021-05, Vol.57 (3), p.377-383 |
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| creator | Samoilova, N. A. Krayukhina, M. A. Anuchina, N. M. Popov, D. A. |
| description | In this work, water-soluble polymer composites containing two antimicrobial components, silver nanoparticles and phenol ligands, are obtained. The maleic-acid groups of the used matrix, a copolymer of maleic acid with ethylene, contributed to the production of noncovalent polymer conjugates of p-aminophenol. In addition, they were easily transformed thermally into reactive residues of maleic anhydride, which allowed the synthesis of covalent polymer complexes of p-aminophenol. Silver nanoparticles were obtained via a reduction of the corresponding metal salt with NaBH
4
in the presence of phenol-polymer conjugates. The resulting colloidal solutions of preparations were active against a number of opportunistic microorganisms. The minimum inhibitory concentrations were 32 and 64 μg/mL for complex drugs against
Escherichia coli
, 8 and 16 μg/mL against
Pseudomonas aeruginosa
, and 4 and 8 μg/mL against
Candida albicans
for nanosilver-containing noncovalent and covalent polymer complexes of
p
-aminophenol, respectively. A pronounced synergistic effect of antibacterial components in the used conjugates is revealed in relation to the specified strains of microorganisms; the fractional inhibitory concentration indexes for the obtained composites were less than 0.5. |
| doi_str_mv | 10.1134/S000368382103011X |
| format | Article |
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4
in the presence of phenol-polymer conjugates. The resulting colloidal solutions of preparations were active against a number of opportunistic microorganisms. The minimum inhibitory concentrations were 32 and 64 μg/mL for complex drugs against
Escherichia coli
, 8 and 16 μg/mL against
Pseudomonas aeruginosa
, and 4 and 8 μg/mL against
Candida albicans
for nanosilver-containing noncovalent and covalent polymer complexes of
p
-aminophenol, respectively. A pronounced synergistic effect of antibacterial components in the used conjugates is revealed in relation to the specified strains of microorganisms; the fractional inhibitory concentration indexes for the obtained composites were less than 0.5.</description><identifier>ISSN: 0003-6838</identifier><identifier>EISSN: 1608-3024</identifier><identifier>DOI: 10.1134/S000368382103011X</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Addition polymerization ; Aminophenol ; Antiinfectives and antibacterials ; Antimicrobial agents ; Biochemistry ; Biomedical and Life Sciences ; Chemical synthesis ; Conjugates ; Coordination compounds ; Copolymers ; E coli ; Life Sciences ; Maleic acid ; Maleic anhydride ; Medical Microbiology ; Microbiology ; Microorganisms ; Nanoparticles ; p-Aminophenol ; Phenolic compounds ; Phenols ; Polymer matrix composites ; Polymers ; Pseudomonas aeruginosa ; Reduction (metal working) ; Residues ; Silver ; Synergistic effect ; Water soluble polymers</subject><ispartof>Applied biochemistry and microbiology, 2021-05, Vol.57 (3), p.377-383</ispartof><rights>Pleiades Publishing, Inc. 2021. ISSN 0003-6838, Applied Biochemistry and Microbiology, 2021, Vol. 57, No. 3, pp. 377–383. © Pleiades Publishing, Inc., 2021. Russian Text © The Author(s), 2021, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2021, Vol. 57, No. 3, pp. 274–281.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-b340caed4434f2d6484a941506bf65296915f8dd0fe84e71e14c88d303b558863</citedby><cites>FETCH-LOGICAL-c353t-b340caed4434f2d6484a941506bf65296915f8dd0fe84e71e14c88d303b558863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S000368382103011X$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S000368382103011X$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids></links><search><creatorcontrib>Samoilova, N. A.</creatorcontrib><creatorcontrib>Krayukhina, M. A.</creatorcontrib><creatorcontrib>Anuchina, N. M.</creatorcontrib><creatorcontrib>Popov, D. A.</creatorcontrib><title>Study of Antimicrobial Properties of Preparations Based on Maleic-Acid Copolymers Containing Silver Nanoparticles and Phenolic Residues</title><title>Applied biochemistry and microbiology</title><addtitle>Appl Biochem Microbiol</addtitle><description>In this work, water-soluble polymer composites containing two antimicrobial components, silver nanoparticles and phenol ligands, are obtained. The maleic-acid groups of the used matrix, a copolymer of maleic acid with ethylene, contributed to the production of noncovalent polymer conjugates of p-aminophenol. In addition, they were easily transformed thermally into reactive residues of maleic anhydride, which allowed the synthesis of covalent polymer complexes of p-aminophenol. Silver nanoparticles were obtained via a reduction of the corresponding metal salt with NaBH
4
in the presence of phenol-polymer conjugates. The resulting colloidal solutions of preparations were active against a number of opportunistic microorganisms. The minimum inhibitory concentrations were 32 and 64 μg/mL for complex drugs against
Escherichia coli
, 8 and 16 μg/mL against
Pseudomonas aeruginosa
, and 4 and 8 μg/mL against
Candida albicans
for nanosilver-containing noncovalent and covalent polymer complexes of
p
-aminophenol, respectively. A pronounced synergistic effect of antibacterial components in the used conjugates is revealed in relation to the specified strains of microorganisms; the fractional inhibitory concentration indexes for the obtained composites were less than 0.5.</description><subject>Addition polymerization</subject><subject>Aminophenol</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Chemical synthesis</subject><subject>Conjugates</subject><subject>Coordination compounds</subject><subject>Copolymers</subject><subject>E coli</subject><subject>Life Sciences</subject><subject>Maleic acid</subject><subject>Maleic anhydride</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Nanoparticles</subject><subject>p-Aminophenol</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Polymer matrix composites</subject><subject>Polymers</subject><subject>Pseudomonas aeruginosa</subject><subject>Reduction (metal working)</subject><subject>Residues</subject><subject>Silver</subject><subject>Synergistic effect</subject><subject>Water soluble polymers</subject><issn>0003-6838</issn><issn>1608-3024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kM1KAzEUhYMoWKsP4C7gejSZZNLMshb_oGqxCu6GzOROjUyTMUmFPoGvbYYKLsTVvZdzvnPhIHRKyTmljF8sCSFMSCZzShih9HUPjaggMmMk5_toNMjZoB-ioxDe01kKWY7Q1zJu9Ba7Fk9tNGvTeFcb1eGFdz34aCAM2sJDr7yKxtmAL1UAjZ3F96oD02TTxmg8c73rtmvwIa02KmONXeGl6T7B4wdlXeKjabqUp6zGizewrjMNfoJg9AbCMTpoVRfg5GeO0cv11fPsNps_3tzNpvOsYQWLWc04aRRozhlvcy245KrktCCibkWRl6KkRSu1Ji1IDhMKlDdSakZYXRRSCjZGZ7vc3ruP9DdW727jbXpZ5UUqMCecT5KL7lypjhA8tFXvzVr5bUVJNfRd_ek7MfmOCclrV-B_k_-HvgF8ooMm</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Samoilova, N. A.</creator><creator>Krayukhina, M. A.</creator><creator>Anuchina, N. M.</creator><creator>Popov, D. A.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20210501</creationdate><title>Study of Antimicrobial Properties of Preparations Based on Maleic-Acid Copolymers Containing Silver Nanoparticles and Phenolic Residues</title><author>Samoilova, N. A. ; Krayukhina, M. A. ; Anuchina, N. M. ; Popov, D. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-b340caed4434f2d6484a941506bf65296915f8dd0fe84e71e14c88d303b558863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Addition polymerization</topic><topic>Aminophenol</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Chemical synthesis</topic><topic>Conjugates</topic><topic>Coordination compounds</topic><topic>Copolymers</topic><topic>E coli</topic><topic>Life Sciences</topic><topic>Maleic acid</topic><topic>Maleic anhydride</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Microorganisms</topic><topic>Nanoparticles</topic><topic>p-Aminophenol</topic><topic>Phenolic compounds</topic><topic>Phenols</topic><topic>Polymer matrix composites</topic><topic>Polymers</topic><topic>Pseudomonas aeruginosa</topic><topic>Reduction (metal working)</topic><topic>Residues</topic><topic>Silver</topic><topic>Synergistic effect</topic><topic>Water soluble polymers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samoilova, N. A.</creatorcontrib><creatorcontrib>Krayukhina, M. A.</creatorcontrib><creatorcontrib>Anuchina, N. M.</creatorcontrib><creatorcontrib>Popov, D. A.</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Applied biochemistry and microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samoilova, N. A.</au><au>Krayukhina, M. A.</au><au>Anuchina, N. M.</au><au>Popov, D. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of Antimicrobial Properties of Preparations Based on Maleic-Acid Copolymers Containing Silver Nanoparticles and Phenolic Residues</atitle><jtitle>Applied biochemistry and microbiology</jtitle><stitle>Appl Biochem Microbiol</stitle><date>2021-05-01</date><risdate>2021</risdate><volume>57</volume><issue>3</issue><spage>377</spage><epage>383</epage><pages>377-383</pages><issn>0003-6838</issn><eissn>1608-3024</eissn><abstract>In this work, water-soluble polymer composites containing two antimicrobial components, silver nanoparticles and phenol ligands, are obtained. The maleic-acid groups of the used matrix, a copolymer of maleic acid with ethylene, contributed to the production of noncovalent polymer conjugates of p-aminophenol. In addition, they were easily transformed thermally into reactive residues of maleic anhydride, which allowed the synthesis of covalent polymer complexes of p-aminophenol. Silver nanoparticles were obtained via a reduction of the corresponding metal salt with NaBH
4
in the presence of phenol-polymer conjugates. The resulting colloidal solutions of preparations were active against a number of opportunistic microorganisms. The minimum inhibitory concentrations were 32 and 64 μg/mL for complex drugs against
Escherichia coli
, 8 and 16 μg/mL against
Pseudomonas aeruginosa
, and 4 and 8 μg/mL against
Candida albicans
for nanosilver-containing noncovalent and covalent polymer complexes of
p
-aminophenol, respectively. A pronounced synergistic effect of antibacterial components in the used conjugates is revealed in relation to the specified strains of microorganisms; the fractional inhibitory concentration indexes for the obtained composites were less than 0.5.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S000368382103011X</doi><tpages>7</tpages></addata></record> |
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| subjects | Addition polymerization Aminophenol Antiinfectives and antibacterials Antimicrobial agents Biochemistry Biomedical and Life Sciences Chemical synthesis Conjugates Coordination compounds Copolymers E coli Life Sciences Maleic acid Maleic anhydride Medical Microbiology Microbiology Microorganisms Nanoparticles p-Aminophenol Phenolic compounds Phenols Polymer matrix composites Polymers Pseudomonas aeruginosa Reduction (metal working) Residues Silver Synergistic effect Water soluble polymers |
| title | Study of Antimicrobial Properties of Preparations Based on Maleic-Acid Copolymers Containing Silver Nanoparticles and Phenolic Residues |
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