Recombinant Antigens E6 and E7 of Human Papilloma Virus Type 16: Preparation, Purification, and Assessment of the Immunogenicity and Antitumor Effects In Vivo

The recombinant proteins E6-CBD and E7-CBD, which are antigens E6 and E7 of human papillomavirus type 16 (HPV16), were connected by a glycine-serine spacer with the cellulose-binding domain (CBD) of Anaerocellum thermophilum in preparations obtained via synthesis in a heterologous expression system...

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Veröffentlicht in:	Applied biochemistry and microbiology 2021-05, Vol.57 (3), p.392-402
Hauptverfasser:	Subbotina, M. E., Grunina, T. M., Sergienko, O. V., Elkina, N. V., Elkin, D. S., Novikova, M. V., Kopnin, P. B., Vinokurova, S. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anogenital Antibodies Anticancer properties Antigens Antitumor activity Biochemistry Biomedical and Life Sciences Cancer Cellulose Cervical cancer Cervix Composition effects E coli Glycine Human papillomavirus Immunization Immunogenicity Life Sciences Medical Microbiology Microbiology Neoplasia Neoplasms Oropharynx Protein purification Proteins Purification Serine Tumors
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