Modulatory Effect of Chaetomorpha gracilis on Erythrocytes Functions and Metabolic Disorders in Mice Fed a High-cholesterol Diet
The current study was carried out to estimate the protective effect of methanolic extract of Chaetomorpha gracilis (MECG) against High Cholesterol Diet (HCD) induced erythrocyte damage in mice. The results of the in vitro assay showed that MECG have higher antioxidant capacities in the DPPH, TAC, AB...
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| Veröffentlicht in: | Journal of Oleo Science 2021, Vol.70(6), pp.837-848 |
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| creator | Brahmi, Noura Hamed, Houda Kallel, Chomous Elleuch, Aida Ayadi, Fatma Makni Allagui, Mohamed Salah |
| description | The current study was carried out to estimate the protective effect of methanolic extract of Chaetomorpha gracilis (MECG) against High Cholesterol Diet (HCD) induced erythrocyte damage in mice. The results of the in vitro assay showed that MECG have higher antioxidant capacities in the DPPH, TAC, ABTS, NBT, NO. inhibition assays. The HPLC analysis confirmed that this potential antioxidant seems to be due to the active compounds, in particular polyphenols, flavonoids. HCD promoted oxidative stress with a rise the level of malonaldehyde (MDA), advanced oxidation protein product (AOPP) levels and a significant decrease of the Vitamin C content, as well the antioxidant enzyme activities such as superoxide dismutase and glutathione peroxidase. In addition, HCD treatment caused significant lipid profile disorders via increase the cholesterol, triglycerides and LDL levels and reduction HDL-Ch level. A statistically significant decrease of Mg2+ and Ca2+ ATPase activities accompanied with a severe damage in the erythrocytes structure and hematological parameters alterations were also noted in hypercholesterolemic mice. Pre-treatment with MECG significantly restored biochemical markers and pathological lesions. It can be suggest that supplementation of MECG displays high potential to quench free radicals and attenuates high cholesterol diet induced erythrocytes oxidative stress and related damages. |
| doi_str_mv | 10.5650/jos.ess20104 |
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The results of the in vitro assay showed that MECG have higher antioxidant capacities in the DPPH, TAC, ABTS, NBT, NO. inhibition assays. The HPLC analysis confirmed that this potential antioxidant seems to be due to the active compounds, in particular polyphenols, flavonoids. HCD promoted oxidative stress with a rise the level of malonaldehyde (MDA), advanced oxidation protein product (AOPP) levels and a significant decrease of the Vitamin C content, as well the antioxidant enzyme activities such as superoxide dismutase and glutathione peroxidase. In addition, HCD treatment caused significant lipid profile disorders via increase the cholesterol, triglycerides and LDL levels and reduction HDL-Ch level. A statistically significant decrease of Mg2+ and Ca2+ ATPase activities accompanied with a severe damage in the erythrocytes structure and hematological parameters alterations were also noted in hypercholesterolemic mice. Pre-treatment with MECG significantly restored biochemical markers and pathological lesions. It can be suggest that supplementation of MECG displays high potential to quench free radicals and attenuates high cholesterol diet induced erythrocytes oxidative stress and related damages.</description><identifier>ISSN: 1345-8957</identifier><identifier>EISSN: 1347-3352</identifier><identifier>DOI: 10.5650/jos.ess20104</identifier><language>eng</language><publisher>Tokyo: Japan Oil Chemists' Society</publisher><subject>Antioxidants ; Calcium ions ; Chaetomorpha gracilis ; Cholesterol ; Diet ; Erythrocytes ; Flavonoids ; Free radicals ; Glutathione ; high cholesterol diet ; Lipids ; Metabolic disorders ; mice ; Oxidation ; Oxidative stress ; Peroxidase ; Polyphenols ; Pretreatment ; Structural damage ; Superoxide dismutase ; Triglycerides</subject><ispartof>Journal of Oleo Science, 2021, Vol.70(6), pp.837-848</ispartof><rights>2021 by Japan Oil Chemists' Society</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c588t-6efc97650a7b6708e3423e197683308599eb27177723bdd0d8069b6da9d456bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,1877,27905,27906</link.rule.ids></links><search><creatorcontrib>Brahmi, Noura</creatorcontrib><creatorcontrib>Hamed, Houda</creatorcontrib><creatorcontrib>Kallel, Chomous</creatorcontrib><creatorcontrib>Elleuch, Aida</creatorcontrib><creatorcontrib>Ayadi, Fatma Makni</creatorcontrib><creatorcontrib>Allagui, Mohamed Salah</creatorcontrib><creatorcontrib>Hematology Laboratory</creatorcontrib><creatorcontrib>Laboratory of Biochemistry</creatorcontrib><creatorcontrib>Sfax Faculty of Sciences</creatorcontrib><creatorcontrib>Laboratory of Animal Physiology</creatorcontrib><creatorcontrib>University of Sfax</creatorcontrib><creatorcontrib>CHU habibbourguiba of Sfax</creatorcontrib><creatorcontrib>CHU Habib Bourguiba</creatorcontrib><title>Modulatory Effect of Chaetomorpha gracilis on Erythrocytes Functions and Metabolic Disorders in Mice Fed a High-cholesterol Diet</title><title>Journal of Oleo Science</title><description>The current study was carried out to estimate the protective effect of methanolic extract of Chaetomorpha gracilis (MECG) against High Cholesterol Diet (HCD) induced erythrocyte damage in mice. The results of the in vitro assay showed that MECG have higher antioxidant capacities in the DPPH, TAC, ABTS, NBT, NO. inhibition assays. The HPLC analysis confirmed that this potential antioxidant seems to be due to the active compounds, in particular polyphenols, flavonoids. HCD promoted oxidative stress with a rise the level of malonaldehyde (MDA), advanced oxidation protein product (AOPP) levels and a significant decrease of the Vitamin C content, as well the antioxidant enzyme activities such as superoxide dismutase and glutathione peroxidase. In addition, HCD treatment caused significant lipid profile disorders via increase the cholesterol, triglycerides and LDL levels and reduction HDL-Ch level. A statistically significant decrease of Mg2+ and Ca2+ ATPase activities accompanied with a severe damage in the erythrocytes structure and hematological parameters alterations were also noted in hypercholesterolemic mice. Pre-treatment with MECG significantly restored biochemical markers and pathological lesions. It can be suggest that supplementation of MECG displays high potential to quench free radicals and attenuates high cholesterol diet induced erythrocytes oxidative stress and related damages.</description><subject>Antioxidants</subject><subject>Calcium ions</subject><subject>Chaetomorpha gracilis</subject><subject>Cholesterol</subject><subject>Diet</subject><subject>Erythrocytes</subject><subject>Flavonoids</subject><subject>Free radicals</subject><subject>Glutathione</subject><subject>high cholesterol diet</subject><subject>Lipids</subject><subject>Metabolic disorders</subject><subject>mice</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Peroxidase</subject><subject>Polyphenols</subject><subject>Pretreatment</subject><subject>Structural damage</subject><subject>Superoxide dismutase</subject><subject>Triglycerides</subject><issn>1345-8957</issn><issn>1347-3352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpFkEtvGyEUhUdRKyVNs8sPQOq2k_IYHrNsXTupFKubdo0YuONhhAcX8MK7_PSSuEk3F3T5zjnc2zS3BN9xwfGXOeY7yJligruL5oqwTraMcfru5c5b1XN52XzIeca49rm8ap620R2DKTGd0HocwRYUR7SaDJS4j-kwGbRLxvrgM4oLWqdTmVK0pwIZbY6LLT4uGZnFoS0UM8TgLfruc0wOUkZ-QVtvAW3AIYMe_G5q7RQD5AIphgpC-di8H03IcPPvvG5-b9a_Vg_t48_7H6uvj63lSpVWwGh7WYc0chASK2AdZUBqSzGGFe97GKgkUkrKBuewU1j0g3Cmdx0Xw8ium09n30OKf471B3qOx7TUSE05430nRE8r9flM2RRzTjDqQ_J7k06aYP2846rK-nXHFb8_43tw3poQl-AX-O_sZlmnrQqKKdEYS4yFrkqNFZO1dIopwigj1enb2WnOxezgLdak4m2Al1iJtXgur_Fvj3YyScPC_gKs2Z-Q</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Brahmi, Noura</creator><creator>Hamed, Houda</creator><creator>Kallel, Chomous</creator><creator>Elleuch, Aida</creator><creator>Ayadi, Fatma Makni</creator><creator>Allagui, Mohamed Salah</creator><general>Japan Oil Chemists' Society</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>20210101</creationdate><title>Modulatory Effect of Chaetomorpha gracilis on Erythrocytes Functions and Metabolic Disorders in Mice Fed a High-cholesterol Diet</title><author>Brahmi, Noura ; Hamed, Houda ; Kallel, Chomous ; Elleuch, Aida ; Ayadi, Fatma Makni ; Allagui, Mohamed Salah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-6efc97650a7b6708e3423e197683308599eb27177723bdd0d8069b6da9d456bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidants</topic><topic>Calcium ions</topic><topic>Chaetomorpha gracilis</topic><topic>Cholesterol</topic><topic>Diet</topic><topic>Erythrocytes</topic><topic>Flavonoids</topic><topic>Free radicals</topic><topic>Glutathione</topic><topic>high cholesterol diet</topic><topic>Lipids</topic><topic>Metabolic disorders</topic><topic>mice</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Peroxidase</topic><topic>Polyphenols</topic><topic>Pretreatment</topic><topic>Structural damage</topic><topic>Superoxide dismutase</topic><topic>Triglycerides</topic><toplevel>online_resources</toplevel><creatorcontrib>Brahmi, Noura</creatorcontrib><creatorcontrib>Hamed, Houda</creatorcontrib><creatorcontrib>Kallel, Chomous</creatorcontrib><creatorcontrib>Elleuch, Aida</creatorcontrib><creatorcontrib>Ayadi, Fatma Makni</creatorcontrib><creatorcontrib>Allagui, Mohamed Salah</creatorcontrib><creatorcontrib>Hematology Laboratory</creatorcontrib><creatorcontrib>Laboratory of Biochemistry</creatorcontrib><creatorcontrib>Sfax Faculty of Sciences</creatorcontrib><creatorcontrib>Laboratory of Animal Physiology</creatorcontrib><creatorcontrib>University of Sfax</creatorcontrib><creatorcontrib>CHU habibbourguiba of Sfax</creatorcontrib><creatorcontrib>CHU Habib Bourguiba</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>Journal of Oleo Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brahmi, Noura</au><au>Hamed, Houda</au><au>Kallel, Chomous</au><au>Elleuch, Aida</au><au>Ayadi, Fatma Makni</au><au>Allagui, Mohamed Salah</au><aucorp>Hematology Laboratory</aucorp><aucorp>Laboratory of Biochemistry</aucorp><aucorp>Sfax Faculty of Sciences</aucorp><aucorp>Laboratory of Animal Physiology</aucorp><aucorp>University of Sfax</aucorp><aucorp>CHU habibbourguiba of Sfax</aucorp><aucorp>CHU Habib Bourguiba</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulatory Effect of Chaetomorpha gracilis on Erythrocytes Functions and Metabolic Disorders in Mice Fed a High-cholesterol Diet</atitle><jtitle>Journal of Oleo Science</jtitle><date>2021-01-01</date><risdate>2021</risdate><volume>70</volume><issue>6</issue><spage>837</spage><epage>848</epage><pages>837-848</pages><issn>1345-8957</issn><eissn>1347-3352</eissn><abstract>The current study was carried out to estimate the protective effect of methanolic extract of Chaetomorpha gracilis (MECG) against High Cholesterol Diet (HCD) induced erythrocyte damage in mice. The results of the in vitro assay showed that MECG have higher antioxidant capacities in the DPPH, TAC, ABTS, NBT, NO. inhibition assays. The HPLC analysis confirmed that this potential antioxidant seems to be due to the active compounds, in particular polyphenols, flavonoids. HCD promoted oxidative stress with a rise the level of malonaldehyde (MDA), advanced oxidation protein product (AOPP) levels and a significant decrease of the Vitamin C content, as well the antioxidant enzyme activities such as superoxide dismutase and glutathione peroxidase. In addition, HCD treatment caused significant lipid profile disorders via increase the cholesterol, triglycerides and LDL levels and reduction HDL-Ch level. A statistically significant decrease of Mg2+ and Ca2+ ATPase activities accompanied with a severe damage in the erythrocytes structure and hematological parameters alterations were also noted in hypercholesterolemic mice. Pre-treatment with MECG significantly restored biochemical markers and pathological lesions. It can be suggest that supplementation of MECG displays high potential to quench free radicals and attenuates high cholesterol diet induced erythrocytes oxidative stress and related damages.</abstract><cop>Tokyo</cop><pub>Japan Oil Chemists' Society</pub><doi>10.5650/jos.ess20104</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Calcium ions Chaetomorpha gracilis Cholesterol Diet Erythrocytes Flavonoids Free radicals Glutathione high cholesterol diet Lipids Metabolic disorders mice Oxidation Oxidative stress Peroxidase Polyphenols Pretreatment Structural damage Superoxide dismutase Triglycerides |
| title | Modulatory Effect of Chaetomorpha gracilis on Erythrocytes Functions and Metabolic Disorders in Mice Fed a High-cholesterol Diet |
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