Particulate Matter-Induced Cardiovascular Dysfunction: A Mechanistic Insight
Air pollution and particulate matter (PM) are significant factors for adverse health effects most prominently cardiovascular disease (CVD). PM is produced from various sources, which include both natural and anthropogenic. It is composed of biological components, organic compounds, minerals, and met...
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Veröffentlicht in: | Cardiovascular toxicology 2021-07, Vol.21 (7), p.505-516 |
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description | Air pollution and particulate matter (PM) are significant factors for adverse health effects most prominently cardiovascular disease (CVD). PM is produced from various sources, which include both natural and anthropogenic. It is composed of biological components, organic compounds, minerals, and metals, which are responsible for inducing inflammation and adverse health effects. However, the adverse effects are related to PM size distribution. Finer particles are a significant cause of cardiovascular events. This review discusses the direct and indirect mechanisms of PM-induced CVD like myocardial infarction, the elevation of blood pressure, cardiac arrhythmias, atherosclerosis, and thrombosis. The two potential mechanisms are oxidative stress and systemic inflammation. Prenatal exposure has also been linked with cardiovascular outcomes later in life. Moreover, we also mentioned the epidemiological studies that strongly associate PM with CVD. |
doi_str_mv | 10.1007/s12012-021-09652-3 |
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PM is produced from various sources, which include both natural and anthropogenic. It is composed of biological components, organic compounds, minerals, and metals, which are responsible for inducing inflammation and adverse health effects. However, the adverse effects are related to PM size distribution. Finer particles are a significant cause of cardiovascular events. This review discusses the direct and indirect mechanisms of PM-induced CVD like myocardial infarction, the elevation of blood pressure, cardiac arrhythmias, atherosclerosis, and thrombosis. The two potential mechanisms are oxidative stress and systemic inflammation. Prenatal exposure has also been linked with cardiovascular outcomes later in life. 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PM is produced from various sources, which include both natural and anthropogenic. It is composed of biological components, organic compounds, minerals, and metals, which are responsible for inducing inflammation and adverse health effects. However, the adverse effects are related to PM size distribution. Finer particles are a significant cause of cardiovascular events. This review discusses the direct and indirect mechanisms of PM-induced CVD like myocardial infarction, the elevation of blood pressure, cardiac arrhythmias, atherosclerosis, and thrombosis. The two potential mechanisms are oxidative stress and systemic inflammation. Prenatal exposure has also been linked with cardiovascular outcomes later in life. Moreover, we also mentioned the epidemiological studies that strongly associate PM with CVD.</description><subject>Air Pollutants - adverse effects</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Animals</subject><subject>Anthropogenic factors</subject><subject>Arrhythmia</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood clot</subject><subject>Blood pressure</subject><subject>Cardiology</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - chemically induced</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Cardiovascular System - drug effects</subject><subject>Cardiovascular System - metabolism</subject><subject>Cardiovascular System - physiopathology</subject><subject>Environmental Exposure - adverse effects</subject><subject>Epidemiology</subject><subject>Epigenesis, Genetic - drug effects</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Heart</subject><subject>Heart attack</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Metals</subject><subject>Minerals</subject><subject>Myocardial infarction</subject><subject>Organic compounds</subject><subject>Outdoor air quality</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Particle Size</subject><subject>Particle size distribution</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Particulate Matter - adverse effects</subject><subject>Pharmacology/Toxicology</subject><subject>Pollution effects</subject><subject>Prenatal experience</subject><subject>Prenatal exposure</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Size distribution</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Time Factors</subject><issn>1530-7905</issn><issn>1559-0259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1PGzEQhq2qqFDaP9BDtVLPC2N77fVyi0JbIgXRQ3u2Jv4IRokXbC8S_75OQ0FICM1hRjPPO2PrJeQLhRMK0J9myoCyFhhtYZCCtfwdOaJCDLUlhve7mkPbDyAOycecbwAYY1J8IIecKyWhk0dk-QtTCWbaYHHNJZbiUruIdjLONnNMNoz3mHfj1Jw_ZD9FU8IYz5pZc-nMNcaQq7pZxBzW1-UTOfC4ye7zYz4mf358_z2_aJdXPxfz2bI1AlRpBeKKu46tlOy96YRkQ4dgqVIcfa2Mp5JKMJZ3rGcCLQg0VFkhB-8QGD8m3_Z7b9N4N7lc9M04pVhPaia46LnqaP9MrXHjdIh-LAnNNmSjZz1IrvpB8kqdvELVsG4bzBidD7X_QsD2ApPGnJPz-jaFLaYHTUHvfNF7X3T1Rf_zRe9EXx9fPK22zj5J_htRAb4Hch3FtUvPX3pj7V9DbJYm</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Ain, Noor Ul</creator><creator>Qamar, Safi Ur Rehman</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0001-9834-2727</orcidid></search><sort><creationdate>20210701</creationdate><title>Particulate Matter-Induced Cardiovascular Dysfunction: A Mechanistic Insight</title><author>Ain, Noor Ul ; Qamar, Safi Ur Rehman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-5aab3e42b867fc456294a0d1883af4a0cf16160cd342725ad05ac18d569fea023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Air Pollutants - adverse effects</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Animals</topic><topic>Anthropogenic factors</topic><topic>Arrhythmia</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood clot</topic><topic>Blood pressure</topic><topic>Cardiology</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - chemically induced</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Cardiovascular System - drug effects</topic><topic>Cardiovascular System - metabolism</topic><topic>Cardiovascular System - physiopathology</topic><topic>Environmental Exposure - adverse effects</topic><topic>Epidemiology</topic><topic>Epigenesis, Genetic - drug effects</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Heart</topic><topic>Heart attack</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Metals</topic><topic>Minerals</topic><topic>Myocardial infarction</topic><topic>Organic compounds</topic><topic>Outdoor air quality</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Particle Size</topic><topic>Particle size distribution</topic><topic>Particulate emissions</topic><topic>Particulate matter</topic><topic>Particulate Matter - adverse effects</topic><topic>Pharmacology/Toxicology</topic><topic>Pollution effects</topic><topic>Prenatal experience</topic><topic>Prenatal exposure</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Size distribution</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ain, Noor Ul</creatorcontrib><creatorcontrib>Qamar, Safi Ur Rehman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Cardiovascular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ain, Noor Ul</au><au>Qamar, Safi Ur Rehman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Particulate Matter-Induced Cardiovascular Dysfunction: A Mechanistic Insight</atitle><jtitle>Cardiovascular toxicology</jtitle><stitle>Cardiovasc Toxicol</stitle><addtitle>Cardiovasc Toxicol</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>21</volume><issue>7</issue><spage>505</spage><epage>516</epage><pages>505-516</pages><issn>1530-7905</issn><eissn>1559-0259</eissn><abstract>Air pollution and particulate matter (PM) are significant factors for adverse health effects most prominently cardiovascular disease (CVD). 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subjects | Air Pollutants - adverse effects Air pollution Air Pollution - adverse effects Animals Anthropogenic factors Arrhythmia Arteriosclerosis Atherosclerosis Biomedical and Life Sciences Biomedicine Blood clot Blood pressure Cardiology Cardiovascular diseases Cardiovascular Diseases - chemically induced Cardiovascular Diseases - epidemiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Cardiovascular System - drug effects Cardiovascular System - metabolism Cardiovascular System - physiopathology Environmental Exposure - adverse effects Epidemiology Epigenesis, Genetic - drug effects Health aspects Health risks Heart Heart attack Humans Inflammation Inflammation Mediators - metabolism Metals Minerals Myocardial infarction Organic compounds Outdoor air quality Oxidative stress Oxidative Stress - drug effects Particle Size Particle size distribution Particulate emissions Particulate matter Particulate Matter - adverse effects Pharmacology/Toxicology Pollution effects Prenatal experience Prenatal exposure Prognosis Risk Assessment Risk Factors Size distribution Thromboembolism Thrombosis Time Factors |
title | Particulate Matter-Induced Cardiovascular Dysfunction: A Mechanistic Insight |
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