Morphine Deteriorates Cisplatin-Induced Cardiotoxicity in Rats and Induces Dose-Dependent Cisplatin Chemoresistance in MCF-7 Human Breast Cancer Cells

Morphine (MOR) is a strong analgesic that is often used in treatment of severe pains during cancer treatment, and thus might be concomitantly used with anticancer drugs as cisplatin (CP). The aim of the current study was to investigate the mechanisms by which MOR can affect CP-induced cardiotoxicity...

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Veröffentlicht in:	Cardiovascular toxicology 2021-07, Vol.21 (7), p.553-562
Hauptverfasser:	El-Sheikh, Azza A. K., Khired, Zenat
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics, Opioid - pharmacology Analgesics, Opioid - toxicity Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Antineoplastic drugs Antioxidants Antitumor agents Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer cells Cardiology Cardiotoxicity Caspase 3 - metabolism Caspase-3 Catalase Chemoresistance Chemotherapy Cisplatin Cisplatin - pharmacology Cisplatin - toxicity Creatine Creatine kinase Cytokines - metabolism Cytotoxicity Disease Models, Animal Dosage and administration Dose-Response Relationship, Drug Drug Interactions Drug Resistance, Neoplasm - drug effects Enzymes Female Glutathione Heart Heart Diseases - chemically induced Heart Diseases - metabolism Heart Diseases - pathology Heart Diseases - prevention & control Humans Inflammation Inflammation Mediators - metabolism Interleukin 6 Kinases L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lipid peroxidation Lipid Peroxidation - drug effects Lipids Male Malondialdehyde Markers MCF-7 Cells Morphine Morphine - pharmacology Morphine - toxicity Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Nitric oxide Oxidants Oxidative stress Oxidative Stress - drug effects Oxidizing agents Peroxidation Pharmacology/Toxicology Rats Rats, Wistar Superoxide dismutase Tissues Toxicity testing
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