Role of liver sinusoidal endothelial cells in liver diseases

Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike other capillaries, they lack an organized basement membrane and have cytoplasm that is penetrated by open fenestrae, making the hepatic microvascular endothelium discontinuous. LSECs have essential roles in the...

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Veröffentlicht in:	Nature reviews. Gastroenterology & hepatology 2021-06, Vol.18 (6), p.411-431
Hauptverfasser:	Gracia-Sancho, Jordi, Caparrós, Esther, Fernández-Iglesias, Anabel, Francés, Rubén
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4020/4021 692/698/690 Biomedicine Capillaries Capillaries - physiopathology Care and treatment Chronic infection Cytoplasm Development and progression Endothelial cells Endothelial Cells - physiology Endothelium Gastroenterology Genetic aspects Genetic regulation Health aspects Hepatocellular carcinoma Hepatocytes Hepatology Homeostasis Humans Immune response Ischemia Liver cancer Liver diseases Liver Diseases - physiopathology Liver Regeneration - physiology Medicine Medicine & Public Health Microvasculature Pathophysiology Phenotype Phenotypes Reperfusion Reperfusion Injury - physiopathology Review Article Therapeutic applications Therapeutic targets Thrombosis
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