Chronic levels of ibuprofen induces haematoxic and histopathology damage in the gills, liver, and kidney of the African sharptooth catfish (Clarias gariepinus)
Numerous active pharmaceutical ingredients (APIs) have been detected in various environmental matrices. Thus, their potential to elicit their toxic effect on non-target organisms is a growing concern, especially in the aquatic environment. This study aimed to investigate the potential toxicity of ib...
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| Veröffentlicht in: | Environmental science and pollution research international 2021-05, Vol.28 (20), p.25603-25613 |
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| description | Numerous active pharmaceutical ingredients (APIs) have been detected in various environmental matrices. Thus, their potential to elicit their toxic effect on non-target organisms is a growing concern, especially in the aquatic environment. This study aimed to investigate the potential toxicity of ibuprofen (IBU) at environmentally relevant concentration on the haematology and histology of the gill, liver, and kidney over 30 days. The 96-h acute toxicity data showed that IBU was moderately toxic to
C. gariepinus
with an LC50 value of 3.78 mg/L. After 15 and 30 days of exposure, there was a significant alteration in haematological indices in the treated fishes when compared to the control group. Throughout the experimental duration, the level of the mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) were consistently lower significantly, in contrast to the control group. IBU induced histopathological deformities in the gills, liver, and kidney of the exposed fishes, with alterations such as showing severe secondary lamella necrosis (SLN), epithelial lifting (EL), mild deformity of the secondary lamella (DSL), mild secondary lamella necrosis (MLN), and mild vascular congestion in the liver and kidney, respectively. This study has demonstrated that IBU at environmentally relevant concentrations can significantly impact the haematology, gills, liver, and kidney of
C. gariepinus
. This study’s results can provide baseline info for regulatory agencies to set safe limits for NSAIDs as a safeguard for the aquatic environment. |
| doi_str_mv | 10.1007/s11356-020-12286-7 |
| format | Article |
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C. gariepinus
with an LC50 value of 3.78 mg/L. After 15 and 30 days of exposure, there was a significant alteration in haematological indices in the treated fishes when compared to the control group. Throughout the experimental duration, the level of the mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) were consistently lower significantly, in contrast to the control group. IBU induced histopathological deformities in the gills, liver, and kidney of the exposed fishes, with alterations such as showing severe secondary lamella necrosis (SLN), epithelial lifting (EL), mild deformity of the secondary lamella (DSL), mild secondary lamella necrosis (MLN), and mild vascular congestion in the liver and kidney, respectively. This study has demonstrated that IBU at environmentally relevant concentrations can significantly impact the haematology, gills, liver, and kidney of
C. gariepinus
. This study’s results can provide baseline info for regulatory agencies to set safe limits for NSAIDs as a safeguard for the aquatic environment.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-020-12286-7</identifier><identifier>PMID: 33464528</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acute toxicity ; Aquatic environment ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Catfish ; Clarias gariepinus ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Gills ; Hematology ; Hemoglobin ; Histology ; Histopathology ; Ibuprofen ; Kidneys ; Lamella ; Liver ; Necrosis ; Nonsteroidal anti-inflammatory drugs ; Nontarget organisms ; Research Article ; Toxicity ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2021-05, Vol.28 (20), p.25603-25613</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-6ef14a052a5af31e65fc8b1a6a0116b13237ba0c047f5ef3f38bde30954d3fc33</citedby><cites>FETCH-LOGICAL-c412t-6ef14a052a5af31e65fc8b1a6a0116b13237ba0c047f5ef3f38bde30954d3fc33</cites><orcidid>0000-0002-2801-7897</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-020-12286-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-020-12286-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33464528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogunwole, Germaine Akinola</creatorcontrib><creatorcontrib>Saliu, Joseph Kayode</creatorcontrib><creatorcontrib>Osuala, Fidelia Ijeoma</creatorcontrib><creatorcontrib>Odunjo, Faith Oluwaseyi</creatorcontrib><title>Chronic levels of ibuprofen induces haematoxic and histopathology damage in the gills, liver, and kidney of the African sharptooth catfish (Clarias gariepinus)</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Numerous active pharmaceutical ingredients (APIs) have been detected in various environmental matrices. Thus, their potential to elicit their toxic effect on non-target organisms is a growing concern, especially in the aquatic environment. This study aimed to investigate the potential toxicity of ibuprofen (IBU) at environmentally relevant concentration on the haematology and histology of the gill, liver, and kidney over 30 days. The 96-h acute toxicity data showed that IBU was moderately toxic to
C. gariepinus
with an LC50 value of 3.78 mg/L. After 15 and 30 days of exposure, there was a significant alteration in haematological indices in the treated fishes when compared to the control group. Throughout the experimental duration, the level of the mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) were consistently lower significantly, in contrast to the control group. IBU induced histopathological deformities in the gills, liver, and kidney of the exposed fishes, with alterations such as showing severe secondary lamella necrosis (SLN), epithelial lifting (EL), mild deformity of the secondary lamella (DSL), mild secondary lamella necrosis (MLN), and mild vascular congestion in the liver and kidney, respectively. This study has demonstrated that IBU at environmentally relevant concentrations can significantly impact the haematology, gills, liver, and kidney of
C. gariepinus
. This study’s results can provide baseline info for regulatory agencies to set safe limits for NSAIDs as a safeguard for the aquatic environment.</description><subject>Acute toxicity</subject><subject>Aquatic environment</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Catfish</subject><subject>Clarias gariepinus</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Gills</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Histology</subject><subject>Histopathology</subject><subject>Ibuprofen</subject><subject>Kidneys</subject><subject>Lamella</subject><subject>Liver</subject><subject>Necrosis</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Nontarget organisms</subject><subject>Research Article</subject><subject>Toxicity</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution 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levels of ibuprofen induces haematoxic and histopathology damage in the gills, liver, and kidney of the African sharptooth catfish (Clarias gariepinus)</title><author>Ogunwole, Germaine Akinola ; Saliu, Joseph Kayode ; Osuala, Fidelia Ijeoma ; Odunjo, Faith Oluwaseyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-6ef14a052a5af31e65fc8b1a6a0116b13237ba0c047f5ef3f38bde30954d3fc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute toxicity</topic><topic>Aquatic environment</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Catfish</topic><topic>Clarias gariepinus</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Gills</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Histology</topic><topic>Histopathology</topic><topic>Ibuprofen</topic><topic>Kidneys</topic><topic>Lamella</topic><topic>Liver</topic><topic>Necrosis</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Nontarget organisms</topic><topic>Research Article</topic><topic>Toxicity</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogunwole, Germaine Akinola</creatorcontrib><creatorcontrib>Saliu, Joseph Kayode</creatorcontrib><creatorcontrib>Osuala, Fidelia Ijeoma</creatorcontrib><creatorcontrib>Odunjo, Faith Oluwaseyi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology 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Basic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogunwole, Germaine Akinola</au><au>Saliu, Joseph Kayode</au><au>Osuala, Fidelia Ijeoma</au><au>Odunjo, Faith Oluwaseyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic levels of ibuprofen induces haematoxic and histopathology damage in the gills, liver, and kidney of the African sharptooth catfish (Clarias gariepinus)</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>28</volume><issue>20</issue><spage>25603</spage><epage>25613</epage><pages>25603-25613</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Numerous active pharmaceutical ingredients (APIs) have been detected in various environmental matrices. Thus, their potential to elicit their toxic effect on non-target organisms is a growing concern, especially in the aquatic environment. This study aimed to investigate the potential toxicity of ibuprofen (IBU) at environmentally relevant concentration on the haematology and histology of the gill, liver, and kidney over 30 days. The 96-h acute toxicity data showed that IBU was moderately toxic to
C. gariepinus
with an LC50 value of 3.78 mg/L. After 15 and 30 days of exposure, there was a significant alteration in haematological indices in the treated fishes when compared to the control group. Throughout the experimental duration, the level of the mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) were consistently lower significantly, in contrast to the control group. IBU induced histopathological deformities in the gills, liver, and kidney of the exposed fishes, with alterations such as showing severe secondary lamella necrosis (SLN), epithelial lifting (EL), mild deformity of the secondary lamella (DSL), mild secondary lamella necrosis (MLN), and mild vascular congestion in the liver and kidney, respectively. This study has demonstrated that IBU at environmentally relevant concentrations can significantly impact the haematology, gills, liver, and kidney of
C. gariepinus
. This study’s results can provide baseline info for regulatory agencies to set safe limits for NSAIDs as a safeguard for the aquatic environment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33464528</pmid><doi>10.1007/s11356-020-12286-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2801-7897</orcidid></addata></record> |
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| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2021-05, Vol.28 (20), p.25603-25613 |
| issn | 0944-1344 1614-7499 |
| language | eng |
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| source | SpringerNature Journals |
| subjects | Acute toxicity Aquatic environment Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Catfish Clarias gariepinus Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Gills Hematology Hemoglobin Histology Histopathology Ibuprofen Kidneys Lamella Liver Necrosis Nonsteroidal anti-inflammatory drugs Nontarget organisms Research Article Toxicity Waste Water Technology Water Management Water Pollution Control |
| title | Chronic levels of ibuprofen induces haematoxic and histopathology damage in the gills, liver, and kidney of the African sharptooth catfish (Clarias gariepinus) |
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