Efficacy and Safety of Lyophilized Articular Cartilage Matrix as an Injectable Facial Filler
Objective To evaluate the efficacy and safety of an injectable lyophilized articular cartilage matrix (LACM) which is in the form of cartilage powder that may increase the convenience of use and become unaffected by donor site morbidity as a potential filler. Methods The safety test was conducted us...
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| Veröffentlicht in: | Aesthetic plastic surgery 2021-06, Vol.45 (3), p.1266-1272 |
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| creator | Hwang, Se Hwan Kim, Do Hyun Nam, Bo Mi Mun, Ji Yeon Seong, Yong Hae Kim, Soo Whan |
| description | Objective
To evaluate the efficacy and safety of an injectable lyophilized articular cartilage matrix (LACM) which is in the form of cartilage powder that may increase the convenience of use and become unaffected by donor site morbidity as a potential filler.
Methods
The safety test was conducted using 20 rabbits with an intravascular embolization model. Commonly used commercial hyaluronic acid (HA), acellular dermal matrix (ADM), polymethyl methacrylate (PMMA), and polylactic acid (PLA) products were selected for comparison of efficacy and adverse effect of LACM. The efficacy test was performed using 30 mice subcutaneous buttock-injection model. Gross assessments of the changes in size of injected materials and histological examinations were conducted.
Results
Regarding the safety test, in one rabbit in the HA group, complete blurring occurred in the left eye, and necrosis of the posterior auricular artery was observed in one rabbit in the ADM group. In the ADM, severe ecchymosis around the injection sites was observed, and the bruises lasted longer than in the other groups. The LACM exhibited faster bruise resolution. Comparing the changes in size between weeks 4 and 12 in the mouse model, no significant changes in size were observed in the LACM (
p
= 0.359), HA (
p
= 0.421), and ADM (
p
= 0.097), but a significant change was observed in the PMMA (
p
= 0.001). In the histological examination, LACM exhibited well-demarcated margins with good biocompatibility.
Conclusion
The LACM shows potential as a facial filler according to the
in vivo
safety and efficacy tests
Level of Evidence V
This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266 |
| doi_str_mv | 10.1007/s00266-020-02017-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2531422259</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2531422259</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-699263e9be8b2fa475d1c44c7d33f8721666b4873c3aae77c53ed143407af0f83</originalsourceid><addsrcrecordid>eNp9kE9LAzEQxYMoWKtfwFPA82r-7Wb3WEqrhYoHFTwIYTab1JS4W5MtuH56U1fw5mGYObzfm5mH0CUl15QQeRMJYUWREUYORWVGj9CECs6ynAl6jCaEFyJjtHg5RWcxbgmhTEoxQa8La50GPWBoG_wI1vQD7ixeD93uzXn3ZRo8C73Tew8BzyGNHjYG30Mf3CeGmDi8ardG91B7g5egHXi8dN6bcI5OLPhoLn77FD0vF0_zu2z9cLuaz9aZ5jnrs6KqWMFNVZuyZhaEzBuqhdCy4dyWMl1dFLUoJdccwEipc26a9JwgEiyxJZ-iq9F3F7qPvYm92nb70KaViuWcCsZYXiUVG1U6dDEGY9UuuHcIg6JEHVJUY4oqJah-UlQ0QXyEYhK3GxP-rP-hvgEvKHP6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2531422259</pqid></control><display><type>article</type><title>Efficacy and Safety of Lyophilized Articular Cartilage Matrix as an Injectable Facial Filler</title><source>SpringerLink Journals - AutoHoldings</source><creator>Hwang, Se Hwan ; Kim, Do Hyun ; Nam, Bo Mi ; Mun, Ji Yeon ; Seong, Yong Hae ; Kim, Soo Whan</creator><creatorcontrib>Hwang, Se Hwan ; Kim, Do Hyun ; Nam, Bo Mi ; Mun, Ji Yeon ; Seong, Yong Hae ; Kim, Soo Whan</creatorcontrib><description>Objective
To evaluate the efficacy and safety of an injectable lyophilized articular cartilage matrix (LACM) which is in the form of cartilage powder that may increase the convenience of use and become unaffected by donor site morbidity as a potential filler.
Methods
The safety test was conducted using 20 rabbits with an intravascular embolization model. Commonly used commercial hyaluronic acid (HA), acellular dermal matrix (ADM), polymethyl methacrylate (PMMA), and polylactic acid (PLA) products were selected for comparison of efficacy and adverse effect of LACM. The efficacy test was performed using 30 mice subcutaneous buttock-injection model. Gross assessments of the changes in size of injected materials and histological examinations were conducted.
Results
Regarding the safety test, in one rabbit in the HA group, complete blurring occurred in the left eye, and necrosis of the posterior auricular artery was observed in one rabbit in the ADM group. In the ADM, severe ecchymosis around the injection sites was observed, and the bruises lasted longer than in the other groups. The LACM exhibited faster bruise resolution. Comparing the changes in size between weeks 4 and 12 in the mouse model, no significant changes in size were observed in the LACM (
p
= 0.359), HA (
p
= 0.421), and ADM (
p
= 0.097), but a significant change was observed in the PMMA (
p
= 0.001). In the histological examination, LACM exhibited well-demarcated margins with good biocompatibility.
Conclusion
The LACM shows potential as a facial filler according to the
in vivo
safety and efficacy tests
Level of Evidence V
This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
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To evaluate the efficacy and safety of an injectable lyophilized articular cartilage matrix (LACM) which is in the form of cartilage powder that may increase the convenience of use and become unaffected by donor site morbidity as a potential filler.
Methods
The safety test was conducted using 20 rabbits with an intravascular embolization model. Commonly used commercial hyaluronic acid (HA), acellular dermal matrix (ADM), polymethyl methacrylate (PMMA), and polylactic acid (PLA) products were selected for comparison of efficacy and adverse effect of LACM. The efficacy test was performed using 30 mice subcutaneous buttock-injection model. Gross assessments of the changes in size of injected materials and histological examinations were conducted.
Results
Regarding the safety test, in one rabbit in the HA group, complete blurring occurred in the left eye, and necrosis of the posterior auricular artery was observed in one rabbit in the ADM group. In the ADM, severe ecchymosis around the injection sites was observed, and the bruises lasted longer than in the other groups. The LACM exhibited faster bruise resolution. Comparing the changes in size between weeks 4 and 12 in the mouse model, no significant changes in size were observed in the LACM (
p
= 0.359), HA (
p
= 0.421), and ADM (
p
= 0.097), but a significant change was observed in the PMMA (
p
= 0.001). In the histological examination, LACM exhibited well-demarcated margins with good biocompatibility.
Conclusion
The LACM shows potential as a facial filler according to the
in vivo
safety and efficacy tests
Level of Evidence V
This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266</description><subject>Cartilage</subject><subject>Evidence-based medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Otorhinolaryngology</subject><subject>Plastic Surgery</subject><subject>Polymethyl methacrylate</subject><issn>0364-216X</issn><issn>1432-5241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE9LAzEQxYMoWKtfwFPA82r-7Wb3WEqrhYoHFTwIYTab1JS4W5MtuH56U1fw5mGYObzfm5mH0CUl15QQeRMJYUWREUYORWVGj9CECs6ynAl6jCaEFyJjtHg5RWcxbgmhTEoxQa8La50GPWBoG_wI1vQD7ixeD93uzXn3ZRo8C73Tew8BzyGNHjYG30Mf3CeGmDi8ardG91B7g5egHXi8dN6bcI5OLPhoLn77FD0vF0_zu2z9cLuaz9aZ5jnrs6KqWMFNVZuyZhaEzBuqhdCy4dyWMl1dFLUoJdccwEipc26a9JwgEiyxJZ-iq9F3F7qPvYm92nb70KaViuWcCsZYXiUVG1U6dDEGY9UuuHcIg6JEHVJUY4oqJah-UlQ0QXyEYhK3GxP-rP-hvgEvKHP6</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Hwang, Se Hwan</creator><creator>Kim, Do Hyun</creator><creator>Nam, Bo Mi</creator><creator>Mun, Ji Yeon</creator><creator>Seong, Yong Hae</creator><creator>Kim, Soo Whan</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-6917-5998</orcidid></search><sort><creationdate>20210601</creationdate><title>Efficacy and Safety of Lyophilized Articular Cartilage Matrix as an Injectable Facial Filler</title><author>Hwang, Se Hwan ; Kim, Do Hyun ; Nam, Bo Mi ; Mun, Ji Yeon ; Seong, Yong Hae ; Kim, Soo Whan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-699263e9be8b2fa475d1c44c7d33f8721666b4873c3aae77c53ed143407af0f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cartilage</topic><topic>Evidence-based medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Otorhinolaryngology</topic><topic>Plastic Surgery</topic><topic>Polymethyl methacrylate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Se Hwan</creatorcontrib><creatorcontrib>Kim, Do Hyun</creatorcontrib><creatorcontrib>Nam, Bo Mi</creatorcontrib><creatorcontrib>Mun, Ji Yeon</creatorcontrib><creatorcontrib>Seong, Yong Hae</creatorcontrib><creatorcontrib>Kim, Soo Whan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Aesthetic plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Se Hwan</au><au>Kim, Do Hyun</au><au>Nam, Bo Mi</au><au>Mun, Ji Yeon</au><au>Seong, Yong Hae</au><au>Kim, Soo Whan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and Safety of Lyophilized Articular Cartilage Matrix as an Injectable Facial Filler</atitle><jtitle>Aesthetic plastic surgery</jtitle><stitle>Aesth Plast Surg</stitle><date>2021-06-01</date><risdate>2021</risdate><volume>45</volume><issue>3</issue><spage>1266</spage><epage>1272</epage><pages>1266-1272</pages><issn>0364-216X</issn><eissn>1432-5241</eissn><abstract>Objective
To evaluate the efficacy and safety of an injectable lyophilized articular cartilage matrix (LACM) which is in the form of cartilage powder that may increase the convenience of use and become unaffected by donor site morbidity as a potential filler.
Methods
The safety test was conducted using 20 rabbits with an intravascular embolization model. Commonly used commercial hyaluronic acid (HA), acellular dermal matrix (ADM), polymethyl methacrylate (PMMA), and polylactic acid (PLA) products were selected for comparison of efficacy and adverse effect of LACM. The efficacy test was performed using 30 mice subcutaneous buttock-injection model. Gross assessments of the changes in size of injected materials and histological examinations were conducted.
Results
Regarding the safety test, in one rabbit in the HA group, complete blurring occurred in the left eye, and necrosis of the posterior auricular artery was observed in one rabbit in the ADM group. In the ADM, severe ecchymosis around the injection sites was observed, and the bruises lasted longer than in the other groups. The LACM exhibited faster bruise resolution. Comparing the changes in size between weeks 4 and 12 in the mouse model, no significant changes in size were observed in the LACM (
p
= 0.359), HA (
p
= 0.421), and ADM (
p
= 0.097), but a significant change was observed in the PMMA (
p
= 0.001). In the histological examination, LACM exhibited well-demarcated margins with good biocompatibility.
Conclusion
The LACM shows potential as a facial filler according to the
in vivo
safety and efficacy tests
Level of Evidence V
This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00266-020-02017-1</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6917-5998</orcidid></addata></record> |
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| ispartof | Aesthetic plastic surgery, 2021-06, Vol.45 (3), p.1266-1272 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Cartilage Evidence-based medicine Medicine Medicine & Public Health Original Article Otorhinolaryngology Plastic Surgery Polymethyl methacrylate |
| title | Efficacy and Safety of Lyophilized Articular Cartilage Matrix as an Injectable Facial Filler |
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