Cannabinoid CB1 receptor mediates METH-induced electrophysiological and morphological alterations in cerebellum Purkinje cells

Our previous studies on cannabinoid type1 receptor (CB1R) activation on Methamphetamine (METH)-induced neurodegeneration and locomotion impairments in male rats suggest an interaction between CB1Rs and METH. However, the role of these receptors in METH-neurotoxicity has not been fully identified. Th...

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Veröffentlicht in:	Human & experimental toxicology 2021-06, Vol.40 (6), p.940-951
Hauptverfasser:	Ramshini, Effat, Sheykhzade, Majid, Dabiri, Shahriar, Shabani, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Cannabinoid CB1 receptors Cell death Cerebellum Cytology Electrophysiological recording Endocannabinoid system Firing rate Latency Locomotion Methamphetamine Neurodegeneration Neurotoxicity Purkinje cells Receptors Staining Therapeutic applications
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