Long non-coding RNA SMASR inhibits the EMT by negatively regulating TGF-β/Smad signaling pathway in lung cancer

TGF-β/Smad signaling pathway plays an important role in EMT during cancer progression. Long non-coding RNAs (lncRNAs) are involved in various behaviors of cancer cells, including EMT. Here, we report a novel lncRNA adjacent to Smad3, named Smad3-associated long non-coding RNA (SMASR). SMASR is downr...

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Veröffentlicht in:	Oncogene 2021-05, Vol.40 (20), p.3578-3592
Hauptverfasser:	Xu, Lele, Liu, Wenzhong, Li, Tongtong, Hu, Yuying, Wang, Yu, Huang, Lijie, Wang, Yan, Shao, Shujuan, Liu, Xuefeng, Zhan, Qimin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/44 13/89 14/19 45/90 631/67/322 631/80/84 82/80 96/109 96/34 Apoptosis Cell Biology Cell Line, Tumor Cell Movement - physiology Epithelial-Mesenchymal Transition Human Genetics Humans Internal Medicine Kinases Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Medicine Medicine & Public Health Non-coding RNA Oncology Phosphorylation Receptor, Transforming Growth Factor-beta Type I - genetics Receptor, Transforming Growth Factor-beta Type I - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction Smad protein Smad2 protein Smad3 protein Smad3 Protein - genetics Smad3 Protein - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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