Protein Binding Partners of Dysregulated miRNAs in Parkinson's Disease Serum
Accumulating evidence suggests that microRNAs (miRNAs) are a contributing factor to neurodegenerative diseases. Although altered miRNA profiles in serum or plasma have been reported for several neurodegenerative diseases, little is known about the interaction between dysregulated miRNAs and their pr...
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| Veröffentlicht in: | Cells (Basel, Switzerland) Switzerland), 2021-04, Vol.10 (4), p.791, Article 791 |
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| creator | Ruf, Wolfgang P. Freischmidt, Axel Grozdanov, Veselin Roth, Valerie Brockmann, Sarah J. Mollenhauer, Brit Martin, Dorothea Haslinger, Bernhard Fundel-Clemens, Katrin Otto, Markus von Arnim, Christine Holzmann, Karlheinz Ludolph, Albert C. Weishaupt, Jochen H. Danzer, Karin M. |
| description | Accumulating evidence suggests that microRNAs (miRNAs) are a contributing factor to neurodegenerative diseases. Although altered miRNA profiles in serum or plasma have been reported for several neurodegenerative diseases, little is known about the interaction between dysregulated miRNAs and their protein binding partners. We found significant alterations of the miRNA abundance pattern in serum and in isolated serum-derived extracellular vesicles of Parkinson's disease (PD) patients. The differential expression of miRNA in PD patients was more robust in serum than in isolated extracellular vesicles and could separate PD patients from healthy controls in an unsupervised approach to a high degree. We identified a novel protein interaction partner for the strongly dysregulated hsa-mir-4745-5p. Our study provides further evidence for the involvement of miRNAs and HNF4a in PD. The demonstration that miRNA-protein binding might mediate the pathologic effects of HNF4a both by direct binding to it and by binding to proteins regulated by it suggests a complex role for miRNAs in pathology beyond the dysregulation of transcription. |
| doi_str_mv | 10.3390/cells10040791 |
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Although altered miRNA profiles in serum or plasma have been reported for several neurodegenerative diseases, little is known about the interaction between dysregulated miRNAs and their protein binding partners. We found significant alterations of the miRNA abundance pattern in serum and in isolated serum-derived extracellular vesicles of Parkinson's disease (PD) patients. The differential expression of miRNA in PD patients was more robust in serum than in isolated extracellular vesicles and could separate PD patients from healthy controls in an unsupervised approach to a high degree. We identified a novel protein interaction partner for the strongly dysregulated hsa-mir-4745-5p. Our study provides further evidence for the involvement of miRNAs and HNF4a in PD. The demonstration that miRNA-protein binding might mediate the pathologic effects of HNF4a both by direct binding to it and by binding to proteins regulated by it suggests a complex role for miRNAs in pathology beyond the dysregulation of transcription.</description><identifier>ISSN: 2073-4409</identifier><identifier>EISSN: 2073-4409</identifier><identifier>DOI: 10.3390/cells10040791</identifier><identifier>PMID: 33918274</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Arrays ; Biomarkers ; Cell Biology ; Cluster analysis ; DNA methylation ; Gene expression ; Genomes ; Hepatocyte nuclear factor 4 ; Life Sciences & Biomedicine ; miRNA ; Movement disorders ; Neurodegenerative diseases ; Parkinson's disease ; Proteins ; Quality control ; Science & Technology ; serum ; Software ; Statistical analysis ; Transcription ; Vesicles ; Yeast</subject><ispartof>Cells (Basel, Switzerland), 2021-04, Vol.10 (4), p.791, Article 791</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Arrays Biomarkers Cell Biology Cluster analysis DNA methylation Gene expression Genomes Hepatocyte nuclear factor 4 Life Sciences & Biomedicine miRNA Movement disorders Neurodegenerative diseases Parkinson's disease Proteins Quality control Science & Technology serum Software Statistical analysis Transcription Vesicles Yeast |
| title | Protein Binding Partners of Dysregulated miRNAs in Parkinson's Disease Serum |
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