Examination of Surfactant Protein D as a Biomarker for Evaluating Pulmonary Toxicity of Nanomaterials in Rat
This work studies the relationship between lung inflammation caused by nanomaterials and surfactant protein D (SP-D) kinetics and investigates whether SP-D can be a biomarker of the pulmonary toxicity of nanomaterials. Nanomaterials of nickel oxide and cerium dioxide were classified as having high t...
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| Veröffentlicht in: | International journal of molecular sciences 2021-04, Vol.22 (9), p.4635, Article 4635 |
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| creator | Tomonaga, Taisuke Izumi, Hiroto Yoshiura, Yukiko Nishida, Chinatsu Yatera, Kazuhiro Morimoto, Yasuo |
| description | This work studies the relationship between lung inflammation caused by nanomaterials and surfactant protein D (SP-D) kinetics and investigates whether SP-D can be a biomarker of the pulmonary toxicity of nanomaterials. Nanomaterials of nickel oxide and cerium dioxide were classified as having high toxicity, nanomaterials of two types of titanium dioxides and zinc oxide were classified as having low toxicity, and rat biological samples obtained from 3 days to 6 months after intratracheal instillation of those nanomaterials and micron-particles of crystalline silica were used. There were different tendencies of increase between the high- and low-toxicity materials in the concentration of SP-D in bronchoalveolar-lavage fluid (BALF) and serum and in the expression of the SP-D gene in the lung tissue. An analysis of the receiver operating characteristics for the toxicity of the nanomaterials by SP-D in BALF and serum showed a high accuracy of discrimination from 1 week to 3 or 6 months after exposure. These data suggest that the differences in the expression of SP-D in BALF and serum depended on the level of lung inflammation caused by the nanomaterials and that SP-D can be biomarkers for evaluating the pulmonary toxicity of nanomaterials. |
| doi_str_mv | 10.3390/ijms22094635 |
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Nanomaterials of nickel oxide and cerium dioxide were classified as having high toxicity, nanomaterials of two types of titanium dioxides and zinc oxide were classified as having low toxicity, and rat biological samples obtained from 3 days to 6 months after intratracheal instillation of those nanomaterials and micron-particles of crystalline silica were used. There were different tendencies of increase between the high- and low-toxicity materials in the concentration of SP-D in bronchoalveolar-lavage fluid (BALF) and serum and in the expression of the SP-D gene in the lung tissue. An analysis of the receiver operating characteristics for the toxicity of the nanomaterials by SP-D in BALF and serum showed a high accuracy of discrimination from 1 week to 3 or 6 months after exposure. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Nanomaterials of nickel oxide and cerium dioxide were classified as having high toxicity, nanomaterials of two types of titanium dioxides and zinc oxide were classified as having low toxicity, and rat biological samples obtained from 3 days to 6 months after intratracheal instillation of those nanomaterials and micron-particles of crystalline silica were used. There were different tendencies of increase between the high- and low-toxicity materials in the concentration of SP-D in bronchoalveolar-lavage fluid (BALF) and serum and in the expression of the SP-D gene in the lung tissue. An analysis of the receiver operating characteristics for the toxicity of the nanomaterials by SP-D in BALF and serum showed a high accuracy of discrimination from 1 week to 3 or 6 months after exposure. These data suggest that the differences in the expression of SP-D in BALF and serum depended on the level of lung inflammation caused by the nanomaterials and that SP-D can be biomarkers for evaluating the pulmonary toxicity of nanomaterials.</description><subject>Alveoli</subject><subject>Animals</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biological properties</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Bronchus</subject><subject>Chemistry</subject><subject>Chemistry, Multidisciplinary</subject><subject>D gene</subject><subject>Evaluation</subject><subject>Gene expression</subject><subject>Inflammation</subject><subject>Interferon</subject><subject>kinetics</subject><subject>Life Sciences & Biomedicine</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Lungs</subject><subject>Male</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanostructures - 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methods</topic><topic>Toxicity Tests - standards</topic><topic>Trachea</topic><topic>Zinc oxide</topic><topic>Zinc oxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomonaga, Taisuke</creatorcontrib><creatorcontrib>Izumi, Hiroto</creatorcontrib><creatorcontrib>Yoshiura, Yukiko</creatorcontrib><creatorcontrib>Nishida, Chinatsu</creatorcontrib><creatorcontrib>Yatera, Kazuhiro</creatorcontrib><creatorcontrib>Morimoto, Yasuo</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomonaga, Taisuke</au><au>Izumi, Hiroto</au><au>Yoshiura, Yukiko</au><au>Nishida, Chinatsu</au><au>Yatera, Kazuhiro</au><au>Morimoto, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examination of Surfactant Protein D as a Biomarker for Evaluating Pulmonary Toxicity of Nanomaterials in Rat</atitle><jtitle>International journal of molecular sciences</jtitle><stitle>INT J MOL SCI</stitle><addtitle>Int J Mol Sci</addtitle><date>2021-04-28</date><risdate>2021</risdate><volume>22</volume><issue>9</issue><spage>4635</spage><pages>4635-</pages><artnum>4635</artnum><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>This work studies the relationship between lung inflammation caused by nanomaterials and surfactant protein D (SP-D) kinetics and investigates whether SP-D can be a biomarker of the pulmonary toxicity of nanomaterials. Nanomaterials of nickel oxide and cerium dioxide were classified as having high toxicity, nanomaterials of two types of titanium dioxides and zinc oxide were classified as having low toxicity, and rat biological samples obtained from 3 days to 6 months after intratracheal instillation of those nanomaterials and micron-particles of crystalline silica were used. There were different tendencies of increase between the high- and low-toxicity materials in the concentration of SP-D in bronchoalveolar-lavage fluid (BALF) and serum and in the expression of the SP-D gene in the lung tissue. An analysis of the receiver operating characteristics for the toxicity of the nanomaterials by SP-D in BALF and serum showed a high accuracy of discrimination from 1 week to 3 or 6 months after exposure. These data suggest that the differences in the expression of SP-D in BALF and serum depended on the level of lung inflammation caused by the nanomaterials and that SP-D can be biomarkers for evaluating the pulmonary toxicity of nanomaterials.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>33924924</pmid><doi>10.3390/ijms22094635</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-2955-4432</orcidid><orcidid>https://orcid.org/0000-0002-5339-6905</orcidid><orcidid>https://orcid.org/0000-0003-3583-3785</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alveoli Animals Biochemistry & Molecular Biology Biological properties biomarker Biomarkers Biomarkers - blood Bronchoalveolar Lavage Fluid - chemistry Bronchus Chemistry Chemistry, Multidisciplinary D gene Evaluation Gene expression Inflammation Interferon kinetics Life Sciences & Biomedicine Lung - drug effects Lung - metabolism Lungs Male Nanomaterials Nanoparticles Nanostructures - administration & dosage Nanostructures - toxicity Nanotechnology Neutrophils Physical Sciences Protein D Proteins Pulmonary Surfactant-Associated Protein D - blood pulmonary toxicity Rats Rats, Inbred F344 Science & Technology Surfactant protein D Surfactants Titanium dioxide Toxicity Toxicity Tests - methods Toxicity Tests - standards Trachea Zinc oxide Zinc oxides |
| title | Examination of Surfactant Protein D as a Biomarker for Evaluating Pulmonary Toxicity of Nanomaterials in Rat |
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