Inspired Epigenetic Modulation Synergy with Adenosine Inhibition Elicits Pyroptosis and Potentiates Cancer Immunotherapy

Overcoming innate or adaptive resistance to immune checkpoint inhibitor therapy in solid tumors with limited T‐cell responses remains challenging. Increasing evidence has indicated that epigenetic alterations, especially overexpression of DNA methyltransferase and immunosuppressive adenosine, are ma...

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Veröffentlicht in:	Advanced functional materials 2021-05, Vol.31 (20), p.n/a
Hauptverfasser:	Xiong, Honggang, Ma, Xianbin, Wang, Xiaolong, Su, Wen, Wu, Lei, Zhang, Tian, Xu, Zhigang, Sun, Zhi‐Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine adenosine pathway inhibitors anti‐pd‐l1 Cancer epigenetic modulators Epigenetics Glutathione Immunotherapy Inhibitors Lymphocytes Materials science prodrugs Synergistic effect tumor microenvironments Tumors
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