Synthesis of Highly Substituted Cyclobutanones by a One‐Pot Keteniminium‐Enamine Process

Herein, we describe an effective one‐pot sequence for the regio‐ and stereoselective synthesis of highly substituted cyclobutanones. This process relies on first a [2+2] cycloaddition involving a keteniminium salt intermediate with an alkene followed by isomerization of the resulting cyclobutanimini...

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Veröffentlicht in:	Helvetica chimica acta 2021-05, Vol.104 (5), p.n/a
Hauptverfasser:	Dagoneau, Dylan, Kolleth, Amandine, Quinodoz, Pierre, Horoz, Beyza, Catak, Saron, Lumbroso, Alexandre, Sulzer‐Mossé, Sarah, De Mesmaeker, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Coplanarity Cycloaddition cyclobutanones diastereoselectivity enamines Isomerization keteniminium salts Stereoselectivity Substitutes Synthesis
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