Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus
Pangasianodon hypophthalmus is one of the most important aquaculture species in Southeast Asia, with a significant contribution to the world fish basket. Like other crops, the striped catfish suffers from bacterial diseases that demand the use of antibiotics. The present study has evaluated the safe...
Gespeichert in:
Veröffentlicht in: | Aquaculture research 2021-06, Vol.52 (6), p.2470-2480 |
---|---|
Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 2480 |
---|---|
container_issue | 6 |
container_start_page | 2470 |
container_title | Aquaculture research |
container_volume | 52 |
creator | Manna, Sanjib Kumar Bera, Asit Kumar Das, Nilemesh Bandopadhyay, Chinmay Baitha, Raju Sen Ghadei, Sanjeev Das, Basanta Kumar Kumar, Ashok Ravindran, Rajisha Krishna, Nanitha Patil, Prasanna Kumar |
description | Pangasianodon hypophthalmus is one of the most important aquaculture species in Southeast Asia, with a significant contribution to the world fish basket. Like other crops, the striped catfish suffers from bacterial diseases that demand the use of antibiotics. The present study has evaluated the safety of oxytetracycline, one of the approved and commonly used antibiotics, in this species. Juvenile stages of the fish (31.16 ± 1.03 g) were administered with the antibiotic in feed at the dose rate of 80–800 mg kg−1 body weight daily for 30 days, followed by 10 days of withdrawal observation. Fish health was assessed by the study of behaviour and feed intake, haematology, blood biochemistry, and histopathology. Results showed that up to 30 days of antibiotic treatment resulted in no significant toxic effects in terms of behaviour and fish mortality. However, fish suffered from reduced feed intake and hepatotoxicity evidenced by proliferative and degenerative changes of hepatocytes, and increase in AST and ALT enzyme activities, especially in 400–800 mg kg−1 doses which, however, recovered after withdrawal of the drug. Although few fish died from a bacterial infection at the lowest concentration of the drug used, fish were able to mount adaptive physiological responses best at 80 mg kg−1 fish dosage. The study establishes that in‐feed administration of the antibiotic oxytetracycline @ 80 mg kg−1 fish biomass is safe for therapeutic use in P. hypophthalmus. |
doi_str_mv | 10.1111/are.15096 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2527375925</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2527375925</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3326-529bf7e93e027a151db83e9707db4528426a64a388c80e12cf828c76e149de23</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0EEqWw4A8isWKR1o84TpZVKQ8JCYS6YGc5zoS4Su1gu4L8PSlhy2xm7ujMHekidE3wgoy1VB4WhOMyP0EzwnKeUoLL0-PMecq5eD9HFyHsMCYZZmSGzB1E8HtjVTTOJq5JKuOCaiAORxFbSJSNZlxGoxP3PUSIXulBd8ZC0g61d7rtnDc1JMYmr8p-qGCUdfXo1g6969vYqm5_CJforFFdgKu_Pkfb-812_Zg-vzw8rVfPqWaM5imnZdUIKBlgKhThpK4KBqXAoq4yTouM5irPFCsKXWAgVDcFLbTIgWRlDZTN0c1k23v3eYAQ5c4dvB0_SsqpYIKXlI_U7URp70Lw0Mjem73ygyRYHoOUY5DyN8iRXU7sl-lg-B-Uq7fNdPEDbrt2gg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2527375925</pqid></control><display><type>article</type><title>Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus</title><source>Wiley Blackwell Journals</source><creator>Manna, Sanjib Kumar ; Bera, Asit Kumar ; Das, Nilemesh ; Bandopadhyay, Chinmay ; Baitha, Raju ; Sen Ghadei, Sanjeev ; Das, Basanta Kumar ; Kumar, Ashok ; Ravindran, Rajisha ; Krishna, Nanitha ; Patil, Prasanna Kumar</creator><creatorcontrib>Manna, Sanjib Kumar ; Bera, Asit Kumar ; Das, Nilemesh ; Bandopadhyay, Chinmay ; Baitha, Raju ; Sen Ghadei, Sanjeev ; Das, Basanta Kumar ; Kumar, Ashok ; Ravindran, Rajisha ; Krishna, Nanitha ; Patil, Prasanna Kumar</creatorcontrib><description>Pangasianodon hypophthalmus is one of the most important aquaculture species in Southeast Asia, with a significant contribution to the world fish basket. Like other crops, the striped catfish suffers from bacterial diseases that demand the use of antibiotics. The present study has evaluated the safety of oxytetracycline, one of the approved and commonly used antibiotics, in this species. Juvenile stages of the fish (31.16 ± 1.03 g) were administered with the antibiotic in feed at the dose rate of 80–800 mg kg−1 body weight daily for 30 days, followed by 10 days of withdrawal observation. Fish health was assessed by the study of behaviour and feed intake, haematology, blood biochemistry, and histopathology. Results showed that up to 30 days of antibiotic treatment resulted in no significant toxic effects in terms of behaviour and fish mortality. However, fish suffered from reduced feed intake and hepatotoxicity evidenced by proliferative and degenerative changes of hepatocytes, and increase in AST and ALT enzyme activities, especially in 400–800 mg kg−1 doses which, however, recovered after withdrawal of the drug. Although few fish died from a bacterial infection at the lowest concentration of the drug used, fish were able to mount adaptive physiological responses best at 80 mg kg−1 fish dosage. The study establishes that in‐feed administration of the antibiotic oxytetracycline @ 80 mg kg−1 fish biomass is safe for therapeutic use in P. hypophthalmus.</description><identifier>ISSN: 1355-557X</identifier><identifier>EISSN: 1365-2109</identifier><identifier>DOI: 10.1111/are.15096</identifier><language>eng</language><publisher>Oxford: Hindawi Limited</publisher><subject>Antibiotics ; Aquaculture ; Bacterial diseases ; biochemistry ; Biosafety ; Body weight ; Catfish ; Dosage ; Drug withdrawal ; Drugs ; Enzymatic activity ; Enzyme activity ; Feeds ; Fish ; Freshwater fishes ; Haematology ; Hematology ; Hepatocytes ; Hepatotoxicity ; Histopathology ; Oxytetracycline ; Pangasianodon hypophthalmus ; Physiological responses ; safety</subject><ispartof>Aquaculture research, 2021-06, Vol.52 (6), p.2470-2480</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3326-529bf7e93e027a151db83e9707db4528426a64a388c80e12cf828c76e149de23</citedby><cites>FETCH-LOGICAL-c3326-529bf7e93e027a151db83e9707db4528426a64a388c80e12cf828c76e149de23</cites><orcidid>0000-0002-5488-6172 ; 0000-0002-6629-8992</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fare.15096$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fare.15096$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Manna, Sanjib Kumar</creatorcontrib><creatorcontrib>Bera, Asit Kumar</creatorcontrib><creatorcontrib>Das, Nilemesh</creatorcontrib><creatorcontrib>Bandopadhyay, Chinmay</creatorcontrib><creatorcontrib>Baitha, Raju</creatorcontrib><creatorcontrib>Sen Ghadei, Sanjeev</creatorcontrib><creatorcontrib>Das, Basanta Kumar</creatorcontrib><creatorcontrib>Kumar, Ashok</creatorcontrib><creatorcontrib>Ravindran, Rajisha</creatorcontrib><creatorcontrib>Krishna, Nanitha</creatorcontrib><creatorcontrib>Patil, Prasanna Kumar</creatorcontrib><title>Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus</title><title>Aquaculture research</title><description>Pangasianodon hypophthalmus is one of the most important aquaculture species in Southeast Asia, with a significant contribution to the world fish basket. Like other crops, the striped catfish suffers from bacterial diseases that demand the use of antibiotics. The present study has evaluated the safety of oxytetracycline, one of the approved and commonly used antibiotics, in this species. Juvenile stages of the fish (31.16 ± 1.03 g) were administered with the antibiotic in feed at the dose rate of 80–800 mg kg−1 body weight daily for 30 days, followed by 10 days of withdrawal observation. Fish health was assessed by the study of behaviour and feed intake, haematology, blood biochemistry, and histopathology. Results showed that up to 30 days of antibiotic treatment resulted in no significant toxic effects in terms of behaviour and fish mortality. However, fish suffered from reduced feed intake and hepatotoxicity evidenced by proliferative and degenerative changes of hepatocytes, and increase in AST and ALT enzyme activities, especially in 400–800 mg kg−1 doses which, however, recovered after withdrawal of the drug. Although few fish died from a bacterial infection at the lowest concentration of the drug used, fish were able to mount adaptive physiological responses best at 80 mg kg−1 fish dosage. The study establishes that in‐feed administration of the antibiotic oxytetracycline @ 80 mg kg−1 fish biomass is safe for therapeutic use in P. hypophthalmus.</description><subject>Antibiotics</subject><subject>Aquaculture</subject><subject>Bacterial diseases</subject><subject>biochemistry</subject><subject>Biosafety</subject><subject>Body weight</subject><subject>Catfish</subject><subject>Dosage</subject><subject>Drug withdrawal</subject><subject>Drugs</subject><subject>Enzymatic activity</subject><subject>Enzyme activity</subject><subject>Feeds</subject><subject>Fish</subject><subject>Freshwater fishes</subject><subject>Haematology</subject><subject>Hematology</subject><subject>Hepatocytes</subject><subject>Hepatotoxicity</subject><subject>Histopathology</subject><subject>Oxytetracycline</subject><subject>Pangasianodon hypophthalmus</subject><subject>Physiological responses</subject><subject>safety</subject><issn>1355-557X</issn><issn>1365-2109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOwzAQRS0EEqWw4A8isWKR1o84TpZVKQ8JCYS6YGc5zoS4Su1gu4L8PSlhy2xm7ujMHekidE3wgoy1VB4WhOMyP0EzwnKeUoLL0-PMecq5eD9HFyHsMCYZZmSGzB1E8HtjVTTOJq5JKuOCaiAORxFbSJSNZlxGoxP3PUSIXulBd8ZC0g61d7rtnDc1JMYmr8p-qGCUdfXo1g6969vYqm5_CJforFFdgKu_Pkfb-812_Zg-vzw8rVfPqWaM5imnZdUIKBlgKhThpK4KBqXAoq4yTouM5irPFCsKXWAgVDcFLbTIgWRlDZTN0c1k23v3eYAQ5c4dvB0_SsqpYIKXlI_U7URp70Lw0Mjem73ygyRYHoOUY5DyN8iRXU7sl-lg-B-Uq7fNdPEDbrt2gg</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Manna, Sanjib Kumar</creator><creator>Bera, Asit Kumar</creator><creator>Das, Nilemesh</creator><creator>Bandopadhyay, Chinmay</creator><creator>Baitha, Raju</creator><creator>Sen Ghadei, Sanjeev</creator><creator>Das, Basanta Kumar</creator><creator>Kumar, Ashok</creator><creator>Ravindran, Rajisha</creator><creator>Krishna, Nanitha</creator><creator>Patil, Prasanna Kumar</creator><general>Hindawi Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TN</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-5488-6172</orcidid><orcidid>https://orcid.org/0000-0002-6629-8992</orcidid></search><sort><creationdate>202106</creationdate><title>Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus</title><author>Manna, Sanjib Kumar ; Bera, Asit Kumar ; Das, Nilemesh ; Bandopadhyay, Chinmay ; Baitha, Raju ; Sen Ghadei, Sanjeev ; Das, Basanta Kumar ; Kumar, Ashok ; Ravindran, Rajisha ; Krishna, Nanitha ; Patil, Prasanna Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3326-529bf7e93e027a151db83e9707db4528426a64a388c80e12cf828c76e149de23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibiotics</topic><topic>Aquaculture</topic><topic>Bacterial diseases</topic><topic>biochemistry</topic><topic>Biosafety</topic><topic>Body weight</topic><topic>Catfish</topic><topic>Dosage</topic><topic>Drug withdrawal</topic><topic>Drugs</topic><topic>Enzymatic activity</topic><topic>Enzyme activity</topic><topic>Feeds</topic><topic>Fish</topic><topic>Freshwater fishes</topic><topic>Haematology</topic><topic>Hematology</topic><topic>Hepatocytes</topic><topic>Hepatotoxicity</topic><topic>Histopathology</topic><topic>Oxytetracycline</topic><topic>Pangasianodon hypophthalmus</topic><topic>Physiological responses</topic><topic>safety</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manna, Sanjib Kumar</creatorcontrib><creatorcontrib>Bera, Asit Kumar</creatorcontrib><creatorcontrib>Das, Nilemesh</creatorcontrib><creatorcontrib>Bandopadhyay, Chinmay</creatorcontrib><creatorcontrib>Baitha, Raju</creatorcontrib><creatorcontrib>Sen Ghadei, Sanjeev</creatorcontrib><creatorcontrib>Das, Basanta Kumar</creatorcontrib><creatorcontrib>Kumar, Ashok</creatorcontrib><creatorcontrib>Ravindran, Rajisha</creatorcontrib><creatorcontrib>Krishna, Nanitha</creatorcontrib><creatorcontrib>Patil, Prasanna Kumar</creatorcontrib><collection>CrossRef</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Aquaculture research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manna, Sanjib Kumar</au><au>Bera, Asit Kumar</au><au>Das, Nilemesh</au><au>Bandopadhyay, Chinmay</au><au>Baitha, Raju</au><au>Sen Ghadei, Sanjeev</au><au>Das, Basanta Kumar</au><au>Kumar, Ashok</au><au>Ravindran, Rajisha</au><au>Krishna, Nanitha</au><au>Patil, Prasanna Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus</atitle><jtitle>Aquaculture research</jtitle><date>2021-06</date><risdate>2021</risdate><volume>52</volume><issue>6</issue><spage>2470</spage><epage>2480</epage><pages>2470-2480</pages><issn>1355-557X</issn><eissn>1365-2109</eissn><abstract>Pangasianodon hypophthalmus is one of the most important aquaculture species in Southeast Asia, with a significant contribution to the world fish basket. Like other crops, the striped catfish suffers from bacterial diseases that demand the use of antibiotics. The present study has evaluated the safety of oxytetracycline, one of the approved and commonly used antibiotics, in this species. Juvenile stages of the fish (31.16 ± 1.03 g) were administered with the antibiotic in feed at the dose rate of 80–800 mg kg−1 body weight daily for 30 days, followed by 10 days of withdrawal observation. Fish health was assessed by the study of behaviour and feed intake, haematology, blood biochemistry, and histopathology. Results showed that up to 30 days of antibiotic treatment resulted in no significant toxic effects in terms of behaviour and fish mortality. However, fish suffered from reduced feed intake and hepatotoxicity evidenced by proliferative and degenerative changes of hepatocytes, and increase in AST and ALT enzyme activities, especially in 400–800 mg kg−1 doses which, however, recovered after withdrawal of the drug. Although few fish died from a bacterial infection at the lowest concentration of the drug used, fish were able to mount adaptive physiological responses best at 80 mg kg−1 fish dosage. The study establishes that in‐feed administration of the antibiotic oxytetracycline @ 80 mg kg−1 fish biomass is safe for therapeutic use in P. hypophthalmus.</abstract><cop>Oxford</cop><pub>Hindawi Limited</pub><doi>10.1111/are.15096</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5488-6172</orcidid><orcidid>https://orcid.org/0000-0002-6629-8992</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1355-557X |
ispartof | Aquaculture research, 2021-06, Vol.52 (6), p.2470-2480 |
issn | 1355-557X 1365-2109 |
language | eng |
recordid | cdi_proquest_journals_2527375925 |
source | Wiley Blackwell Journals |
subjects | Antibiotics Aquaculture Bacterial diseases biochemistry Biosafety Body weight Catfish Dosage Drug withdrawal Drugs Enzymatic activity Enzyme activity Feeds Fish Freshwater fishes Haematology Hematology Hepatocytes Hepatotoxicity Histopathology Oxytetracycline Pangasianodon hypophthalmus Physiological responses safety |
title | Determination of biosafety of the antibiotic oxytetracycline hydrochloride in Pangasianodon hypophthalmus |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T08%3A23%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Determination%20of%20biosafety%20of%20the%20antibiotic%20oxytetracycline%20hydrochloride%20in%20Pangasianodon%20hypophthalmus&rft.jtitle=Aquaculture%20research&rft.au=Manna,%20Sanjib%20Kumar&rft.date=2021-06&rft.volume=52&rft.issue=6&rft.spage=2470&rft.epage=2480&rft.pages=2470-2480&rft.issn=1355-557X&rft.eissn=1365-2109&rft_id=info:doi/10.1111/are.15096&rft_dat=%3Cproquest_cross%3E2527375925%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2527375925&rft_id=info:pmid/&rfr_iscdi=true |