PET/MRI assessment of lung nodules in primary abdominal malignancies: sensitivity and outcome analysis
Purpose To evaluate PET/MR lung nodule detection compared to PET/CT or CT, to determine growth of nodules missed by PET/MR, and to investigate the impact of missed nodules on clinical management in primary abdominal malignancies. Methods This retrospective IRB-approved study included [18F]-FDG PET/M...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2021-06, Vol.48 (6), p.1976-1986 |
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| container_end_page | 1986 |
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| container_issue | 6 |
| container_start_page | 1976 |
| container_title | European journal of nuclear medicine and molecular imaging |
| container_volume | 48 |
| creator | Biondetti, Pierpaolo Vangel, Mark G. Lahoud, Rita M. Furtado, Felipe S. Rosen, Bruce R. Groshar, David Canamaque, Lina G. Umutlu, Lale Zhang, Eric W. Mahmood, Umar Digumarthy, Subba R. Shepard, Jo-Anne O. Catalano, Onofrio A. |
| description | Purpose
To evaluate PET/MR lung nodule detection compared to PET/CT or CT, to determine growth of nodules missed by PET/MR, and to investigate the impact of missed nodules on clinical management in primary abdominal malignancies.
Methods
This retrospective IRB-approved study included [18F]-FDG PET/MR in 126 patients. All had standard of care chest imaging (SCI) with diagnostic chest CT or PET/CT within 6 weeks of PET/MR that served as standard of reference. Two radiologists assessed lung nodules (size, location, consistency, position, and [18F]-FDG avidity) on SCI and PET/MR. A side-by-side analysis of nodules on SCI and PET/MR was performed. The nodules missed on PET/MR were assessed on follow-up SCI to ascertain their growth (≥ 2 mm); their impact on management was also investigated.
Results
A total of 505 nodules (mean 4 mm, range 1–23 mm) were detected by SCI in 89/126 patients (66M:60F, mean age 60 years). PET/MR detected 61 nodules for a sensitivity of 28.1% for patient and 12.1% for nodule, with higher sensitivity for > 7 mm nodules ( 70% respectively,
p
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| doi_str_mv | 10.1007/s00259-020-05113-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_proquest_journals_2525231804</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2525231804</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-e82d67c68538ce42a306f0a37bd8ac81f7e448aed6def208aad77ebd6fb67b1f3</originalsourceid><addsrcrecordid>eNqNkUGL1TAUhYMozjj6B1xIwI0gdW6SNkndyWPUgRFFxnVJm5tHhjYZe1tl_r3RPp_gQiSLnMV3Lveew9hTAa8EgDknANm0FUiooBFCVeIeOxVatJUB294_agMn7BHRDYCw0rYP2YlStWhqpU5Z-HRxff7h8yV3REg0YVp4Dnxc056n7NcRicfEb-c4ufmOu97nKSY38smNcZ9cGiLSa06YKC7xW1wKkzzP6zLkCYt24x1FesweBDcSPjn8Z-zL24vr3fvq6uO7y92bq2pQplkqtNJrM2jbKDtgLZ0CHcAp03vrBiuCwbq2Dr32GCRY57wx2Hsdem16EdQZe7HNvZ3z1xVp6aZIA46jS5hX6mRtdKOtqmVBn_-F3uR1LvsWqilPCQt1oeRGDXMmmjF0hyg6Ad3PFrqtha600P1qoRPF9Owweu0n9EfL79gLYDfgO_Y5UMkwDXjEAEBD0wLYokDu4uKWmNMur2kp1pf_by202mgqRNrj_OfIf-z_A4A-tB4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2525231804</pqid></control><display><type>article</type><title>PET/MRI assessment of lung nodules in primary abdominal malignancies: sensitivity and outcome analysis</title><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>SpringerNature Journals</source><creator>Biondetti, Pierpaolo ; Vangel, Mark G. ; Lahoud, Rita M. ; Furtado, Felipe S. ; Rosen, Bruce R. ; Groshar, David ; Canamaque, Lina G. ; Umutlu, Lale ; Zhang, Eric W. ; Mahmood, Umar ; Digumarthy, Subba R. ; Shepard, Jo-Anne O. ; Catalano, Onofrio A.</creator><creatorcontrib>Biondetti, Pierpaolo ; Vangel, Mark G. ; Lahoud, Rita M. ; Furtado, Felipe S. ; Rosen, Bruce R. ; Groshar, David ; Canamaque, Lina G. ; Umutlu, Lale ; Zhang, Eric W. ; Mahmood, Umar ; Digumarthy, Subba R. ; Shepard, Jo-Anne O. ; Catalano, Onofrio A.</creatorcontrib><description>Purpose
To evaluate PET/MR lung nodule detection compared to PET/CT or CT, to determine growth of nodules missed by PET/MR, and to investigate the impact of missed nodules on clinical management in primary abdominal malignancies.
Methods
This retrospective IRB-approved study included [18F]-FDG PET/MR in 126 patients. All had standard of care chest imaging (SCI) with diagnostic chest CT or PET/CT within 6 weeks of PET/MR that served as standard of reference. Two radiologists assessed lung nodules (size, location, consistency, position, and [18F]-FDG avidity) on SCI and PET/MR. A side-by-side analysis of nodules on SCI and PET/MR was performed. The nodules missed on PET/MR were assessed on follow-up SCI to ascertain their growth (≥ 2 mm); their impact on management was also investigated.
Results
A total of 505 nodules (mean 4 mm, range 1–23 mm) were detected by SCI in 89/126 patients (66M:60F, mean age 60 years). PET/MR detected 61 nodules for a sensitivity of 28.1% for patient and 12.1% for nodule, with higher sensitivity for > 7 mm nodules (< 30% and > 70% respectively,
p
< 0.05). 75/337 (22.3%) of the nodules missed on PET/MR (follow-up mean 736 days) demonstrated growth. In patients positive for nodules at SCI and negative at PET/MR, missed nodules did not influence patients’ management.
Conclusions
Sensitivity of lung nodule detection on PET/MR is affected by nodule size and is lower than SCI. 22.3% of missed nodules increased on follow-up likely representing metastases. Although this did not impact clinical management in study group with primary abdominal malignancy, largely composed of extra-thoracic advanced stage cancers, with possible different implications in patients without extra-thoracic spread.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-020-05113-1</identifier><identifier>PMID: 33415433</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdomen ; Avidity ; Cardiology ; Chest ; Computed tomography ; Fluorine isotopes ; Gastric cancer ; Imaging ; Life Sciences & Biomedicine ; Lung nodules ; Lungs ; Magnetic resonance imaging ; Malignancy ; Medicine ; Medicine & Public Health ; Metastases ; Nodules ; Nuclear Medicine ; Oncology ; Oncology - Chest ; Original Article ; Orthopedics ; Position (location) ; Positron emission ; Radiology ; Radiology, Nuclear Medicine & Medical Imaging ; Science & Technology ; Sensitivity analysis ; Thorax ; Tomography</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2021-06, Vol.48 (6), p.1976-1986</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>18</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000605900800002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c375t-e82d67c68538ce42a306f0a37bd8ac81f7e448aed6def208aad77ebd6fb67b1f3</citedby><cites>FETCH-LOGICAL-c375t-e82d67c68538ce42a306f0a37bd8ac81f7e448aed6def208aad77ebd6fb67b1f3</cites><orcidid>0000-0001-7733-4138 ; 0000-0001-7414-6123</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-020-05113-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-020-05113-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,39267,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33415433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biondetti, Pierpaolo</creatorcontrib><creatorcontrib>Vangel, Mark G.</creatorcontrib><creatorcontrib>Lahoud, Rita M.</creatorcontrib><creatorcontrib>Furtado, Felipe S.</creatorcontrib><creatorcontrib>Rosen, Bruce R.</creatorcontrib><creatorcontrib>Groshar, David</creatorcontrib><creatorcontrib>Canamaque, Lina G.</creatorcontrib><creatorcontrib>Umutlu, Lale</creatorcontrib><creatorcontrib>Zhang, Eric W.</creatorcontrib><creatorcontrib>Mahmood, Umar</creatorcontrib><creatorcontrib>Digumarthy, Subba R.</creatorcontrib><creatorcontrib>Shepard, Jo-Anne O.</creatorcontrib><creatorcontrib>Catalano, Onofrio A.</creatorcontrib><title>PET/MRI assessment of lung nodules in primary abdominal malignancies: sensitivity and outcome analysis</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>EUR J NUCL MED MOL I</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
To evaluate PET/MR lung nodule detection compared to PET/CT or CT, to determine growth of nodules missed by PET/MR, and to investigate the impact of missed nodules on clinical management in primary abdominal malignancies.
Methods
This retrospective IRB-approved study included [18F]-FDG PET/MR in 126 patients. All had standard of care chest imaging (SCI) with diagnostic chest CT or PET/CT within 6 weeks of PET/MR that served as standard of reference. Two radiologists assessed lung nodules (size, location, consistency, position, and [18F]-FDG avidity) on SCI and PET/MR. A side-by-side analysis of nodules on SCI and PET/MR was performed. The nodules missed on PET/MR were assessed on follow-up SCI to ascertain their growth (≥ 2 mm); their impact on management was also investigated.
Results
A total of 505 nodules (mean 4 mm, range 1–23 mm) were detected by SCI in 89/126 patients (66M:60F, mean age 60 years). PET/MR detected 61 nodules for a sensitivity of 28.1% for patient and 12.1% for nodule, with higher sensitivity for > 7 mm nodules (< 30% and > 70% respectively,
p
< 0.05). 75/337 (22.3%) of the nodules missed on PET/MR (follow-up mean 736 days) demonstrated growth. In patients positive for nodules at SCI and negative at PET/MR, missed nodules did not influence patients’ management.
Conclusions
Sensitivity of lung nodule detection on PET/MR is affected by nodule size and is lower than SCI. 22.3% of missed nodules increased on follow-up likely representing metastases. Although this did not impact clinical management in study group with primary abdominal malignancy, largely composed of extra-thoracic advanced stage cancers, with possible different implications in patients without extra-thoracic spread.</description><subject>Abdomen</subject><subject>Avidity</subject><subject>Cardiology</subject><subject>Chest</subject><subject>Computed tomography</subject><subject>Fluorine isotopes</subject><subject>Gastric cancer</subject><subject>Imaging</subject><subject>Life Sciences & Biomedicine</subject><subject>Lung nodules</subject><subject>Lungs</subject><subject>Magnetic resonance imaging</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Nodules</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Oncology - Chest</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Position (location)</subject><subject>Positron emission</subject><subject>Radiology</subject><subject>Radiology, Nuclear Medicine & Medical Imaging</subject><subject>Science & Technology</subject><subject>Sensitivity analysis</subject><subject>Thorax</subject><subject>Tomography</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUGL1TAUhYMozjj6B1xIwI0gdW6SNkndyWPUgRFFxnVJm5tHhjYZe1tl_r3RPp_gQiSLnMV3Lveew9hTAa8EgDknANm0FUiooBFCVeIeOxVatJUB294_agMn7BHRDYCw0rYP2YlStWhqpU5Z-HRxff7h8yV3REg0YVp4Dnxc056n7NcRicfEb-c4ufmOu97nKSY38smNcZ9cGiLSa06YKC7xW1wKkzzP6zLkCYt24x1FesweBDcSPjn8Z-zL24vr3fvq6uO7y92bq2pQplkqtNJrM2jbKDtgLZ0CHcAp03vrBiuCwbq2Dr32GCRY57wx2Hsdem16EdQZe7HNvZ3z1xVp6aZIA46jS5hX6mRtdKOtqmVBn_-F3uR1LvsWqilPCQt1oeRGDXMmmjF0hyg6Ad3PFrqtha600P1qoRPF9Owweu0n9EfL79gLYDfgO_Y5UMkwDXjEAEBD0wLYokDu4uKWmNMur2kp1pf_by202mgqRNrj_OfIf-z_A4A-tB4</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Biondetti, Pierpaolo</creator><creator>Vangel, Mark G.</creator><creator>Lahoud, Rita M.</creator><creator>Furtado, Felipe S.</creator><creator>Rosen, Bruce R.</creator><creator>Groshar, David</creator><creator>Canamaque, Lina G.</creator><creator>Umutlu, Lale</creator><creator>Zhang, Eric W.</creator><creator>Mahmood, Umar</creator><creator>Digumarthy, Subba R.</creator><creator>Shepard, Jo-Anne O.</creator><creator>Catalano, Onofrio A.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7733-4138</orcidid><orcidid>https://orcid.org/0000-0001-7414-6123</orcidid></search><sort><creationdate>20210601</creationdate><title>PET/MRI assessment of lung nodules in primary abdominal malignancies: sensitivity and outcome analysis</title><author>Biondetti, Pierpaolo ; Vangel, Mark G. ; Lahoud, Rita M. ; Furtado, Felipe S. ; Rosen, Bruce R. ; Groshar, David ; Canamaque, Lina G. ; Umutlu, Lale ; Zhang, Eric W. ; Mahmood, Umar ; Digumarthy, Subba R. ; Shepard, Jo-Anne O. ; Catalano, Onofrio A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e82d67c68538ce42a306f0a37bd8ac81f7e448aed6def208aad77ebd6fb67b1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdomen</topic><topic>Avidity</topic><topic>Cardiology</topic><topic>Chest</topic><topic>Computed tomography</topic><topic>Fluorine isotopes</topic><topic>Gastric cancer</topic><topic>Imaging</topic><topic>Life Sciences & Biomedicine</topic><topic>Lung nodules</topic><topic>Lungs</topic><topic>Magnetic resonance imaging</topic><topic>Malignancy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Nodules</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Oncology - Chest</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Position (location)</topic><topic>Positron emission</topic><topic>Radiology</topic><topic>Radiology, Nuclear Medicine & Medical Imaging</topic><topic>Science & Technology</topic><topic>Sensitivity analysis</topic><topic>Thorax</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biondetti, Pierpaolo</creatorcontrib><creatorcontrib>Vangel, Mark G.</creatorcontrib><creatorcontrib>Lahoud, Rita M.</creatorcontrib><creatorcontrib>Furtado, Felipe S.</creatorcontrib><creatorcontrib>Rosen, Bruce R.</creatorcontrib><creatorcontrib>Groshar, David</creatorcontrib><creatorcontrib>Canamaque, Lina G.</creatorcontrib><creatorcontrib>Umutlu, Lale</creatorcontrib><creatorcontrib>Zhang, Eric W.</creatorcontrib><creatorcontrib>Mahmood, Umar</creatorcontrib><creatorcontrib>Digumarthy, Subba R.</creatorcontrib><creatorcontrib>Shepard, Jo-Anne O.</creatorcontrib><creatorcontrib>Catalano, Onofrio A.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biondetti, Pierpaolo</au><au>Vangel, Mark G.</au><au>Lahoud, Rita M.</au><au>Furtado, Felipe S.</au><au>Rosen, Bruce R.</au><au>Groshar, David</au><au>Canamaque, Lina G.</au><au>Umutlu, Lale</au><au>Zhang, Eric W.</au><au>Mahmood, Umar</au><au>Digumarthy, Subba R.</au><au>Shepard, Jo-Anne O.</au><au>Catalano, Onofrio A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PET/MRI assessment of lung nodules in primary abdominal malignancies: sensitivity and outcome analysis</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><stitle>EUR J NUCL MED MOL I</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>48</volume><issue>6</issue><spage>1976</spage><epage>1986</epage><pages>1976-1986</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
To evaluate PET/MR lung nodule detection compared to PET/CT or CT, to determine growth of nodules missed by PET/MR, and to investigate the impact of missed nodules on clinical management in primary abdominal malignancies.
Methods
This retrospective IRB-approved study included [18F]-FDG PET/MR in 126 patients. All had standard of care chest imaging (SCI) with diagnostic chest CT or PET/CT within 6 weeks of PET/MR that served as standard of reference. Two radiologists assessed lung nodules (size, location, consistency, position, and [18F]-FDG avidity) on SCI and PET/MR. A side-by-side analysis of nodules on SCI and PET/MR was performed. The nodules missed on PET/MR were assessed on follow-up SCI to ascertain their growth (≥ 2 mm); their impact on management was also investigated.
Results
A total of 505 nodules (mean 4 mm, range 1–23 mm) were detected by SCI in 89/126 patients (66M:60F, mean age 60 years). PET/MR detected 61 nodules for a sensitivity of 28.1% for patient and 12.1% for nodule, with higher sensitivity for > 7 mm nodules (< 30% and > 70% respectively,
p
< 0.05). 75/337 (22.3%) of the nodules missed on PET/MR (follow-up mean 736 days) demonstrated growth. In patients positive for nodules at SCI and negative at PET/MR, missed nodules did not influence patients’ management.
Conclusions
Sensitivity of lung nodule detection on PET/MR is affected by nodule size and is lower than SCI. 22.3% of missed nodules increased on follow-up likely representing metastases. Although this did not impact clinical management in study group with primary abdominal malignancy, largely composed of extra-thoracic advanced stage cancers, with possible different implications in patients without extra-thoracic spread.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33415433</pmid><doi>10.1007/s00259-020-05113-1</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7733-4138</orcidid><orcidid>https://orcid.org/0000-0001-7414-6123</orcidid></addata></record> |
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| source | Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; SpringerNature Journals |
| subjects | Abdomen Avidity Cardiology Chest Computed tomography Fluorine isotopes Gastric cancer Imaging Life Sciences & Biomedicine Lung nodules Lungs Magnetic resonance imaging Malignancy Medicine Medicine & Public Health Metastases Nodules Nuclear Medicine Oncology Oncology - Chest Original Article Orthopedics Position (location) Positron emission Radiology Radiology, Nuclear Medicine & Medical Imaging Science & Technology Sensitivity analysis Thorax Tomography |
| title | PET/MRI assessment of lung nodules in primary abdominal malignancies: sensitivity and outcome analysis |
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