Ameliorative effect of fractionated low-dose gamma radiation in combination with ellagic acid on nicotine-induced hormonal changes and testicular toxicity in rats
Nicotine is an active pharmacological ingredient in cigarette smoke, which may negatively influence the male reproductive system and fertility. This study aims to investigate the effect of fractionated low-dose radiation (fractionated-LDR) and/or ellagic acid (EA) on nicotine-induced hormonal change...
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| Veröffentlicht in: | Environmental science and pollution research international 2021-05, Vol.28 (18), p.23287-23300 |
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| creator | Ashoub, Aliaa H. Abdel-Naby, Doaa H. Safar, Marwa M. El-Ghazaly, Mona A. Kenawy, Sanaa A. |
| description | Nicotine is an active pharmacological ingredient in cigarette smoke, which may negatively influence the male reproductive system and fertility. This study aims to investigate the effect of fractionated low-dose radiation (fractionated-LDR) and/or ellagic acid (EA) on nicotine-induced hormonal changes and testicular toxicity in rats. Nicotine was administrated orally (1 mg/kg) for 30 days, afterward, rats were treated with LDR (2 × 0.25 Gy/1-week interval), EA (10 mg/kg, 14 consecutive days p.o.), or a combination of both fractionated-LDR and EA. Rats were sacrificed 24 h after the last dose of treatment, then testes were dissected for histopathology examination, along with some biochemical parameters in serum and testicular tissue were evaluated. Nicotine-induced oxidative stress was evidenced by an increase in testicular thiobarbituric acid reactive substances (TBARS) and a decrease in reduced glutathione (GSH) content. Additionally, the activities of testicular androgenic enzymes were decreased, and the activity of serum lactate dehydrogenase (LDH) was significantly increased. The hormonal changes were verified by a noticeable reduction in follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone serum levels. Histological evaluation revealed that the testicular seminiferous tubules structure was distorted. On the contrary, fractionated-LDR plus EA attenuated the negative changes caused by nicotine observed through biochemical and histological findings. Accordingly, the exposure to fractionated-LDR combined with EA may be a promising candidate for treating hormonal changes and testicular toxicity caused by nicotine. |
| doi_str_mv | 10.1007/s11356-020-12334-2 |
| format | Article |
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This study aims to investigate the effect of fractionated low-dose radiation (fractionated-LDR) and/or ellagic acid (EA) on nicotine-induced hormonal changes and testicular toxicity in rats. Nicotine was administrated orally (1 mg/kg) for 30 days, afterward, rats were treated with LDR (2 × 0.25 Gy/1-week interval), EA (10 mg/kg, 14 consecutive days p.o.), or a combination of both fractionated-LDR and EA. Rats were sacrificed 24 h after the last dose of treatment, then testes were dissected for histopathology examination, along with some biochemical parameters in serum and testicular tissue were evaluated. Nicotine-induced oxidative stress was evidenced by an increase in testicular thiobarbituric acid reactive substances (TBARS) and a decrease in reduced glutathione (GSH) content. Additionally, the activities of testicular androgenic enzymes were decreased, and the activity of serum lactate dehydrogenase (LDH) was significantly increased. The hormonal changes were verified by a noticeable reduction in follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone serum levels. Histological evaluation revealed that the testicular seminiferous tubules structure was distorted. On the contrary, fractionated-LDR plus EA attenuated the negative changes caused by nicotine observed through biochemical and histological findings. Accordingly, the exposure to fractionated-LDR combined with EA may be a promising candidate for treating hormonal changes and testicular toxicity caused by nicotine.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-020-12334-2</identifier><identifier>PMID: 33443739</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; blood serum ; Cigarette smoke ; cigarettes ; Dosage ; Earth and Environmental Science ; Ecotoxicology ; Ellagic acid ; Ellagic Acid - metabolism ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Evaluation ; Fertility ; Follicle-stimulating hormone ; fractionation ; gamma radiation ; Gamma Rays ; Glutathione ; histology ; Histopathology ; ingredients ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Luteinizing hormone ; Male ; Nicotine ; Nicotine - toxicity ; Oral administration ; Oxidative Stress ; Radiation ; Radiation dosage ; Rats ; Reproductive system ; Research Article ; Serum levels ; smoke ; Testes ; Testis - metabolism ; Testosterone ; Testosterone - metabolism ; Thiobarbituric acid ; Thiobarbituric Acid Reactive Substances - metabolism ; Toxicity ; Tubules ; Waste Water Technology ; Water Management ; Water Pollution Control ; γ Radiation</subject><ispartof>Environmental science and pollution research international, 2021-05, Vol.28 (18), p.23287-23300</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-d46b630b0ba30d620491f4082705a30a8856d567159947fc98f62879bdcb70ff3</citedby><cites>FETCH-LOGICAL-c445t-d46b630b0ba30d620491f4082705a30a8856d567159947fc98f62879bdcb70ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-020-12334-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-020-12334-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33443739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashoub, Aliaa H.</creatorcontrib><creatorcontrib>Abdel-Naby, Doaa H.</creatorcontrib><creatorcontrib>Safar, Marwa M.</creatorcontrib><creatorcontrib>El-Ghazaly, Mona A.</creatorcontrib><creatorcontrib>Kenawy, Sanaa A.</creatorcontrib><title>Ameliorative effect of fractionated low-dose gamma radiation in combination with ellagic acid on nicotine-induced hormonal changes and testicular toxicity in rats</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Nicotine is an active pharmacological ingredient in cigarette smoke, which may negatively influence the male reproductive system and fertility. This study aims to investigate the effect of fractionated low-dose radiation (fractionated-LDR) and/or ellagic acid (EA) on nicotine-induced hormonal changes and testicular toxicity in rats. Nicotine was administrated orally (1 mg/kg) for 30 days, afterward, rats were treated with LDR (2 × 0.25 Gy/1-week interval), EA (10 mg/kg, 14 consecutive days p.o.), or a combination of both fractionated-LDR and EA. Rats were sacrificed 24 h after the last dose of treatment, then testes were dissected for histopathology examination, along with some biochemical parameters in serum and testicular tissue were evaluated. Nicotine-induced oxidative stress was evidenced by an increase in testicular thiobarbituric acid reactive substances (TBARS) and a decrease in reduced glutathione (GSH) content. Additionally, the activities of testicular androgenic enzymes were decreased, and the activity of serum lactate dehydrogenase (LDH) was significantly increased. The hormonal changes were verified by a noticeable reduction in follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone serum levels. Histological evaluation revealed that the testicular seminiferous tubules structure was distorted. On the contrary, fractionated-LDR plus EA attenuated the negative changes caused by nicotine observed through biochemical and histological findings. Accordingly, the exposure to fractionated-LDR combined with EA may be a promising candidate for treating hormonal changes and testicular toxicity caused by nicotine.</description><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>blood serum</subject><subject>Cigarette smoke</subject><subject>cigarettes</subject><subject>Dosage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Ellagic acid</subject><subject>Ellagic Acid - metabolism</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Evaluation</subject><subject>Fertility</subject><subject>Follicle-stimulating hormone</subject><subject>fractionation</subject><subject>gamma radiation</subject><subject>Gamma Rays</subject><subject>Glutathione</subject><subject>histology</subject><subject>Histopathology</subject><subject>ingredients</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Luteinizing hormone</subject><subject>Male</subject><subject>Nicotine</subject><subject>Nicotine - 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Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashoub, Aliaa H.</au><au>Abdel-Naby, Doaa H.</au><au>Safar, Marwa M.</au><au>El-Ghazaly, Mona A.</au><au>Kenawy, Sanaa A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ameliorative effect of fractionated low-dose gamma radiation in combination with ellagic acid on nicotine-induced hormonal changes and testicular toxicity in rats</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>28</volume><issue>18</issue><spage>23287</spage><epage>23300</epage><pages>23287-23300</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Nicotine is an active pharmacological ingredient in cigarette smoke, which may negatively influence the male reproductive system and fertility. This study aims to investigate the effect of fractionated low-dose radiation (fractionated-LDR) and/or ellagic acid (EA) on nicotine-induced hormonal changes and testicular toxicity in rats. Nicotine was administrated orally (1 mg/kg) for 30 days, afterward, rats were treated with LDR (2 × 0.25 Gy/1-week interval), EA (10 mg/kg, 14 consecutive days p.o.), or a combination of both fractionated-LDR and EA. Rats were sacrificed 24 h after the last dose of treatment, then testes were dissected for histopathology examination, along with some biochemical parameters in serum and testicular tissue were evaluated. Nicotine-induced oxidative stress was evidenced by an increase in testicular thiobarbituric acid reactive substances (TBARS) and a decrease in reduced glutathione (GSH) content. Additionally, the activities of testicular androgenic enzymes were decreased, and the activity of serum lactate dehydrogenase (LDH) was significantly increased. The hormonal changes were verified by a noticeable reduction in follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone serum levels. Histological evaluation revealed that the testicular seminiferous tubules structure was distorted. On the contrary, fractionated-LDR plus EA attenuated the negative changes caused by nicotine observed through biochemical and histological findings. Accordingly, the exposure to fractionated-LDR combined with EA may be a promising candidate for treating hormonal changes and testicular toxicity caused by nicotine.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33443739</pmid><doi>10.1007/s11356-020-12334-2</doi><tpages>14</tpages></addata></record> |
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| subjects | Animals Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution blood serum Cigarette smoke cigarettes Dosage Earth and Environmental Science Ecotoxicology Ellagic acid Ellagic Acid - metabolism Environment Environmental Chemistry Environmental Health Environmental science Evaluation Fertility Follicle-stimulating hormone fractionation gamma radiation Gamma Rays Glutathione histology Histopathology ingredients L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Luteinizing hormone Male Nicotine Nicotine - toxicity Oral administration Oxidative Stress Radiation Radiation dosage Rats Reproductive system Research Article Serum levels smoke Testes Testis - metabolism Testosterone Testosterone - metabolism Thiobarbituric acid Thiobarbituric Acid Reactive Substances - metabolism Toxicity Tubules Waste Water Technology Water Management Water Pollution Control γ Radiation |
| title | Ameliorative effect of fractionated low-dose gamma radiation in combination with ellagic acid on nicotine-induced hormonal changes and testicular toxicity in rats |
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