Pharmacokinetics of docetaxel and ritonavir after oral administration of ModraDoc006/r in patients with prostate cancer versus patients with other advanced solid tumours

Purpose ModraDoc006 is a novel oral formulation of docetaxel. The clearance of intravenous docetaxel is higher in medically castrated prostate cancer patients as compared to patients with other types of solid tumours. Oral docetaxel requires co-administration ritonavir (r), which might further impac...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2021-06, Vol.87 (6), p.855-869
Hauptverfasser:	Vermunt, Marit A. C., van der Heijden, Lisa T., Hendrikx, Jeroen J. M. A., Schinkel, Alfred H., de Weger, Vincent A., van der Putten, Eric, van Triest, Baukelien, Bergman, Andries M., Beijnen, Jos H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral drugs Antiviral drugs Cancer Research Castration Clinical trials Dosage Exposure Intravenous administration Medicine Medicine & Public Health Metastases Metastasis NCT NCT01173913 NCT03066154 NCT03136640 Oncology Oral administration Original Article Pharmacokinetics Pharmacology Pharmacology/Toxicology Prostate cancer Registration Ritonavir Schedules Solid tumors Tumors
Online-Zugang:	Volltext
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