PPAR-δ activation reduces cisplatin-induced apoptosis via inhibiting p53/Bax/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells

Background Cisplatin-induced injury of renal proximal tubular cells results basically from increased apoptosis via mitochondrial damage, and is mitigated by appropriate enhancement of autophagy. Peroxisome proliferator-activated receptor-delta (PPAR-δ) reportedly protects against not only mitochondr...

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Veröffentlicht in:	Clinical and experimental nephrology 2021-06, Vol.25 (6), p.598-607
Hauptverfasser:	Shan, Juanping, Kimura, Hideki, Yokoi, Seiji, Kamiyama, Kazuko, Imamoto, Toru, Takeda, Izumi, Kobayashi, Mamiko, Mikami, Daisuke, Takahashi, Naoki, Kasuno, Kenji, Sugaya, Takeshi, Iwano, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein Apoptosis Autophagy Caspase-3 Caspase-9 Cell activation Chemotherapy Cisplatin Cytochrome Cytochrome c Cytosol Endothelium Gene expression Kidneys Medicine Medicine & Public Health Mitochondria Nephrology Original Article p53 Protein Peroxisome proliferator-activated receptors Phagocytosis Phosphorylation Urology
Online-Zugang:	Volltext
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