PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment

Severe asthma accounts for almost half the cost associated with asthma. Severe asthma is driven by heterogeneous molecular mechanisms. Conventional clinical trial design often lacks the power and efficiency to target subgroups with specific pathobiological mechanisms. Furthermore, the validation and...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2021-05, Vol.147 (5), p.1594-1601
Hauptverfasser:	Israel, Elliot, Denlinger, Loren C., Bacharier, Leonard B., LaVange, Lisa M., Moore, Wendy C., Peters, Michael C., Georas, Steve N., Wright, Rosalind J., Mauger, David T., Noel, Patricia, Akuthota, Praveen, Bach, Julia, Bleecker, Eugene R., Cardet, Juan Carlos, Carr, Tara F., Castro, Mario, Cinelli, Angeles, Comhair, Suzy A.A., Covar, Ronina A., Alexander, Laura Crotty, DiMango, Emily A., Erzurum, Serpil C., Fahy, John V., Fajt, Merritt L., Gaston, Benjamin M., Hoffman, Eric A., Holguin, Fernando, Jackson, Daniel J., Jain, Sonia, Jarjour, Nizar N., Ji, Yuan, Kenyon, Nicholas J., Kosorok, Michael R., Kraft, Monica, Krishnan, Jerry A., Kumar, Rajesh, Liu, Andrew H., Liu, Mark C., Ly, Ngoc P., Marquis, M. Alison, Martinez, Fernando D., Moy, James N., O’Neal, Wanda K., Ortega, Victor E., Peden, David B., Phipatanakul, Wanda, Ross, Kristie, Smith, Lewis J., Szefler, Stanley J., Teague, W. Gerald, Tulchinsky, Abigail F., Vijayanand, Pandurangan, Wechsler, Michael E., Wenzel, Sally E., White, Steven R., Zeki, Amir A., Ivanova, Anastasia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Clinical Trials as Topic adaptive design Asthma Biomarkers clinical trial Clinical trials Design FDA approval Humans Intervention master protocol Molecular modelling Objectives Placebos platform trial Precision Medicine Randomized Controlled Trials as Topic Research Design Severe asthma therapy
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