Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs

Mast cell and basophil activation by antigen cross-linking of FcεRI-bound IgE is central to allergy pathogenesis. We previously demonstrated global suppression of this process by rapid desensitization with anti-FcεRIα mAbs. We sought to determine whether use of monovalent (mv) anti-FcεRIα mAbs incre...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2021-05, Vol.147 (5), p.1838-1854.e4
Hauptverfasser:	Khodoun, Marat V., Morris, Suzanne C., Shao, Wen-Hai, Potter, Crystal, Angerman, Elizabeth, Kiselev, Artem, Yarawsky, Alexander E., Herr, Andrew B., Klausz, Katja, Otte, Anna, Peipp, Matthias, Finkelman, Fred D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Allergens Anaphylaxis Anaphylaxis - drug therapy Anaphylaxis - immunology Animals Anti-Allergic Agents - pharmacology Anti-Allergic Agents - therapeutic use Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antigens Cell activation Chromatography Cloning Cord blood cross-linking desensitization Desensitization (Psychology) Drug dosages Female Food allergies Food Hypersensitivity - drug therapy Food Hypersensitivity - immunology humanized IgG1 IgG4 IL-4 Immunodeficiency Immunoglobulin E Immunoglobulin E - immunology Immunoglobulin G - immunology Interleukin 4 Male mast cell Mast cells Mast Cells - drug effects Mast Cells - immunology Mice Mice, Inbred BALB C Mice, Transgenic Monoclonal antibodies Mouse Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - immunology Proteins Receptors, IgE - genetics Receptors, IgE - immunology Syk Syk Kinase - immunology
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