Copper‐mediated nucleophilic radiofluorination of [18F]β‐CFT for positron emission tomography imaging of dopamine transporter

[18F]β‐CFT is a positron emission tomography (PET) ligand for imaging of dopamine transporter. It was proved to be a sensitive PET marker to detect presynaptic dopaminergic hypofunction in Parkinson's disease. In recent years, copper‐mediated 18F‐fluorination of aryl boronic esters has been suc...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2021-05, Vol.64 (6), p.228-236
Hauptverfasser:	Yu, Hung‐Man, Li, Ching‐Yun, Liu, Shiu‐Wen, Yang, Chun‐Hung, Chang, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatic compounds boronic pinacol esters Catalysts Copper Copper - chemistry copper‐mediated Dopamine Dopamine Plasma Membrane Transport Proteins - chemistry Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine receptors Dopamine transporter Esters Fluorination Fluorine isotopes Fluorine Radioisotopes - chemistry fluorine‐18 Halogenation Medical imaging Movement disorders Neurodegenerative diseases Nortropanes Parkinson's disease Positron emission Positron emission tomography Positron-Emission Tomography - methods Radiochemistry Radiolabelling Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Tomography
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