Multi-modality management of extraosseous Ewing sarcoma: 10-year experience from a tertiary care centre
Aim:To analyse the presentation, diagnosis and patterns of care of extraosseous Ewing sarcoma treated at our institution between 2008 and 2018.Methods:Electronic medical records of extraosseous Ewing sarcoma patients treated at our institution between January 2008 and April 2018 were reviewed. Kapla...
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| Veröffentlicht in: | Journal of radiotherapy in practice 2021-06, Vol.20 (2), p.189-195 |
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| creator | Sathyamurthy, Arvind Singh, Ashish Jose, Tarun Sebastian, Patricia Balakrishnan, Rajesh Prabhu, Anne Jennifer Backianathan, Selvamani |
| description | Aim:To analyse the presentation, diagnosis and patterns of care of extraosseous Ewing sarcoma treated at our institution between 2008 and 2018.Methods:Electronic medical records of extraosseous Ewing sarcoma patients treated at our institution between January 2008 and April 2018 were reviewed. Kaplan–Meier curves were plotted to assess the overall and disease-free survival with 95% confidence intervals. A univariate analysis was carried out to assess the impact of variables such as surgical excision, completeness of surgery, completeness of chemotherapy and addition of radiation therapy on the survivorship.Results:The records of 65 patients treated at our institution were available for review. The mean age was 26·4 years. The most frequent sites of extraosseous Ewing tumour were kidney—9/65 (13·8%) and brain—10/65 (15·4%). Sixteen (24·6%) patients presented with inoperable/metastatic disease at diagnosis. The other 49 (75·4%) had localised disease at presentation. The median overall survival of the 49 non-metastatic patients was 46 months, and the disease-free survival was 45 months.Conclusion:Extraosseous Ewing sarcoma is a rare and aggressive tumour diagnosed by molecular techniques. Multi-modality treatment including surgical resection with wide margins, adjuvant radiation when indicated and completion of systemic chemotherapy results in optimum outcomes. |
| doi_str_mv | 10.1017/S1460396920000126 |
| format | Article |
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Kaplan–Meier curves were plotted to assess the overall and disease-free survival with 95% confidence intervals. A univariate analysis was carried out to assess the impact of variables such as surgical excision, completeness of surgery, completeness of chemotherapy and addition of radiation therapy on the survivorship.Results:The records of 65 patients treated at our institution were available for review. The mean age was 26·4 years. The most frequent sites of extraosseous Ewing tumour were kidney—9/65 (13·8%) and brain—10/65 (15·4%). Sixteen (24·6%) patients presented with inoperable/metastatic disease at diagnosis. The other 49 (75·4%) had localised disease at presentation. The median overall survival of the 49 non-metastatic patients was 46 months, and the disease-free survival was 45 months.Conclusion:Extraosseous Ewing sarcoma is a rare and aggressive tumour diagnosed by molecular techniques. Multi-modality treatment including surgical resection with wide margins, adjuvant radiation when indicated and completion of systemic chemotherapy results in optimum outcomes.</description><identifier>ISSN: 1460-3969</identifier><identifier>EISSN: 1467-1131</identifier><identifier>DOI: 10.1017/S1460396920000126</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Biopsy ; Chemotherapy ; Completeness ; Confidence intervals ; Diagnosis ; Electronic health records ; Electronic medical records ; Ewing's sarcoma ; Ewings sarcoma ; Lymphoma ; Medical diagnosis ; Metastases ; Metastasis ; Original Article ; Patients ; Polymerase chain reaction ; Proteins ; Radiation ; Radiation therapy ; Sarcoma ; Surgery ; Survival ; Tumors</subject><ispartof>Journal of radiotherapy in practice, 2021-06, Vol.20 (2), p.189-195</ispartof><rights>The Author(s), 2020. Published by Cambridge University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-653caf2643015e5e3b2eaf71624f08451279a5384632a1c01fa788ab729828f93</citedby><cites>FETCH-LOGICAL-c317t-653caf2643015e5e3b2eaf71624f08451279a5384632a1c01fa788ab729828f93</cites><orcidid>0000-0003-1655-0675</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1460396920000126/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids></links><search><creatorcontrib>Sathyamurthy, Arvind</creatorcontrib><creatorcontrib>Singh, Ashish</creatorcontrib><creatorcontrib>Jose, Tarun</creatorcontrib><creatorcontrib>Sebastian, Patricia</creatorcontrib><creatorcontrib>Balakrishnan, Rajesh</creatorcontrib><creatorcontrib>Prabhu, Anne Jennifer</creatorcontrib><creatorcontrib>Backianathan, Selvamani</creatorcontrib><title>Multi-modality management of extraosseous Ewing sarcoma: 10-year experience from a tertiary care centre</title><title>Journal of radiotherapy in practice</title><addtitle>J Radiother Pract</addtitle><description>Aim:To analyse the presentation, diagnosis and patterns of care of extraosseous Ewing sarcoma treated at our institution between 2008 and 2018.Methods:Electronic medical records of extraosseous Ewing sarcoma patients treated at our institution between January 2008 and April 2018 were reviewed. Kaplan–Meier curves were plotted to assess the overall and disease-free survival with 95% confidence intervals. A univariate analysis was carried out to assess the impact of variables such as surgical excision, completeness of surgery, completeness of chemotherapy and addition of radiation therapy on the survivorship.Results:The records of 65 patients treated at our institution were available for review. The mean age was 26·4 years. The most frequent sites of extraosseous Ewing tumour were kidney—9/65 (13·8%) and brain—10/65 (15·4%). Sixteen (24·6%) patients presented with inoperable/metastatic disease at diagnosis. The other 49 (75·4%) had localised disease at presentation. The median overall survival of the 49 non-metastatic patients was 46 months, and the disease-free survival was 45 months.Conclusion:Extraosseous Ewing sarcoma is a rare and aggressive tumour diagnosed by molecular techniques. Multi-modality treatment including surgical resection with wide margins, adjuvant radiation when indicated and completion of systemic chemotherapy results in optimum outcomes.</description><subject>Biopsy</subject><subject>Chemotherapy</subject><subject>Completeness</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Electronic health records</subject><subject>Electronic medical records</subject><subject>Ewing's sarcoma</subject><subject>Ewings sarcoma</subject><subject>Lymphoma</subject><subject>Medical diagnosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Original Article</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Proteins</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Sarcoma</subject><subject>Surgery</subject><subject>Survival</subject><subject>Tumors</subject><issn>1460-3969</issn><issn>1467-1131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1UE1PwzAMrRBIjMEP4BaJcyFO0qTlhqbxIQ1xAM6V1zlTp7UZSSrYvydjkzggfLFlv_dsvyy7BH4NHMzNKyjNZaUrwVOA0EfZKLVMDiDh-Kfm-W5-mp2FsOJcKcXNKFs-D-vY5p1b4LqNW9Zhj0vqqI_MWUZf0aMLgdwQ2PSz7ZcsoG9ch7cMeL4l9AmzId9S3xCz3nUMWSQfW_Rb1qAn1iQtT-fZicV1oItDHmfv99O3yWM-e3l4mtzN8kaCibkuZINWaCU5FFSQnAtCa0ALZXmpChCmwkKWSkuB0HCwaMoS50ZUpShtJcfZ1V53493HQCHWKzf4Pq2sRSG40YYXMqFgj2p8-s6TrTe-7dLJNfB652f9x8_EkQcOdnPfLpb0K_0_6xu-u3aI</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Sathyamurthy, Arvind</creator><creator>Singh, Ashish</creator><creator>Jose, Tarun</creator><creator>Sebastian, Patricia</creator><creator>Balakrishnan, Rajesh</creator><creator>Prabhu, Anne Jennifer</creator><creator>Backianathan, Selvamani</creator><general>Cambridge University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-1655-0675</orcidid></search><sort><creationdate>202106</creationdate><title>Multi-modality management of extraosseous Ewing sarcoma: 10-year experience from a tertiary care centre</title><author>Sathyamurthy, Arvind ; Singh, Ashish ; Jose, Tarun ; Sebastian, Patricia ; Balakrishnan, Rajesh ; Prabhu, Anne Jennifer ; Backianathan, Selvamani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-653caf2643015e5e3b2eaf71624f08451279a5384632a1c01fa788ab729828f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biopsy</topic><topic>Chemotherapy</topic><topic>Completeness</topic><topic>Confidence intervals</topic><topic>Diagnosis</topic><topic>Electronic health records</topic><topic>Electronic medical records</topic><topic>Ewing's sarcoma</topic><topic>Ewings sarcoma</topic><topic>Lymphoma</topic><topic>Medical diagnosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Original Article</topic><topic>Patients</topic><topic>Polymerase chain reaction</topic><topic>Proteins</topic><topic>Radiation</topic><topic>Radiation therapy</topic><topic>Sarcoma</topic><topic>Surgery</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sathyamurthy, Arvind</creatorcontrib><creatorcontrib>Singh, Ashish</creatorcontrib><creatorcontrib>Jose, Tarun</creatorcontrib><creatorcontrib>Sebastian, Patricia</creatorcontrib><creatorcontrib>Balakrishnan, Rajesh</creatorcontrib><creatorcontrib>Prabhu, Anne Jennifer</creatorcontrib><creatorcontrib>Backianathan, Selvamani</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of radiotherapy in practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sathyamurthy, Arvind</au><au>Singh, Ashish</au><au>Jose, Tarun</au><au>Sebastian, Patricia</au><au>Balakrishnan, Rajesh</au><au>Prabhu, Anne Jennifer</au><au>Backianathan, Selvamani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multi-modality management of extraosseous Ewing sarcoma: 10-year experience from a tertiary care centre</atitle><jtitle>Journal of radiotherapy in practice</jtitle><addtitle>J Radiother Pract</addtitle><date>2021-06</date><risdate>2021</risdate><volume>20</volume><issue>2</issue><spage>189</spage><epage>195</epage><pages>189-195</pages><issn>1460-3969</issn><eissn>1467-1131</eissn><abstract>Aim:To analyse the presentation, diagnosis and patterns of care of extraosseous Ewing sarcoma treated at our institution between 2008 and 2018.Methods:Electronic medical records of extraosseous Ewing sarcoma patients treated at our institution between January 2008 and April 2018 were reviewed. Kaplan–Meier curves were plotted to assess the overall and disease-free survival with 95% confidence intervals. A univariate analysis was carried out to assess the impact of variables such as surgical excision, completeness of surgery, completeness of chemotherapy and addition of radiation therapy on the survivorship.Results:The records of 65 patients treated at our institution were available for review. The mean age was 26·4 years. The most frequent sites of extraosseous Ewing tumour were kidney—9/65 (13·8%) and brain—10/65 (15·4%). Sixteen (24·6%) patients presented with inoperable/metastatic disease at diagnosis. The other 49 (75·4%) had localised disease at presentation. The median overall survival of the 49 non-metastatic patients was 46 months, and the disease-free survival was 45 months.Conclusion:Extraosseous Ewing sarcoma is a rare and aggressive tumour diagnosed by molecular techniques. Multi-modality treatment including surgical resection with wide margins, adjuvant radiation when indicated and completion of systemic chemotherapy results in optimum outcomes.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><doi>10.1017/S1460396920000126</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1655-0675</orcidid></addata></record> |
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| ispartof | Journal of radiotherapy in practice, 2021-06, Vol.20 (2), p.189-195 |
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| source | Cambridge University Press Journals Complete |
| subjects | Biopsy Chemotherapy Completeness Confidence intervals Diagnosis Electronic health records Electronic medical records Ewing's sarcoma Ewings sarcoma Lymphoma Medical diagnosis Metastases Metastasis Original Article Patients Polymerase chain reaction Proteins Radiation Radiation therapy Sarcoma Surgery Survival Tumors |
| title | Multi-modality management of extraosseous Ewing sarcoma: 10-year experience from a tertiary care centre |
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