Effects of the L/N-Type Ca2+ Channel Blocker Cilnidipine on the Cardiac Histological Remodelling and Inducibility of Atrial Fibrillation in High-Salt-Fed Rats

High salt intake has been shown to induce hypertrophy and fibrosis in the atria and ventricles, which could result in the development of atrial fibrillation (AF). Whereas the development of AF is suggested to be prevented by renin–angiotensin system (RAS) inhibitors, recent findings have indicated t...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2021/05/01, Vol.44(5), pp.707-713
Hauptverfasser:	Harada, Eri, Sugino, Kazumi, Aimoto, Megumi, Takahara, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Antihypertensives atrial fibrillation Blood pressure Calcium Calcium channels (L-type) Calcium channels (N-type) Cardiac arrhythmia cardiac fibrosis Cilnidipine Diet Diuretics Fibrillation Fibrosis Hypertrophy L/N-type Ca2+ channel blocker Norepinephrine Oral administration Renin Salt salt-sensitive hypertension Sodium chloride Ventricle
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