Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial

Treatment of locally advanced rectal cancer with chemoradiotherapy, surgery, and adjuvant chemotherapy controls local disease, but distant metastases remain common. We aimed to assess whether administering neoadjuvant chemotherapy before preoperative chemoradiotherapy could reduce the risk of distan...

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Veröffentlicht in:	The lancet oncology 2021-05, Vol.22 (5), p.702-715
Hauptverfasser:	Conroy, Thierry, Bosset, Jean-François, Etienne, Pierre-Luc, Rio, Emmanuel, François, Éric, Mesgouez-Nebout, Nathalie, Vendrely, Véronique, Artignan, Xavier, Bouché, Olivier, Gargot, Dany, Boige, Valérie, Bonichon-Lamichhane, Nathalie, Louvet, Christophe, Morand, Clotilde, de la Fouchardière, Christelle, Lamfichekh, Najib, Juzyna, Béata, Jouffroy-Zeller, Claire, Rullier, Eric, Marchal, Frédéric, Gourgou, Sophie, Castan, Florence, Borg, Christophe, Ronchin, Philippe, Seitz, Jean-François, Corbinais, Stéphane, Maillard, Emmanuel, Noirclerc, Monique, El Hajbi, Farid, Villing, Anne-Laure, Bécouarn, Yves, Foong Fat Lam Kam Sang, Lam, Artru, Pascal, Bachet, Jean-Baptiste, Hocine, Fayçal, Ligeza-Poisson, Catherine, Vautravers, Claire, Ben Abdelghani, Meher, Aparicio, Thomas, Desot, Elise, Marquis, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Adenocarcinoma Adult Adverse events Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biopsy Cancer therapies Chemoradiotherapy Chemotherapy Clinical medicine Colorectal cancer Diarrhea Disease control Dosage Female Fluorouracil - adverse effects Fluorouracil - therapeutic use Hospitals Humans Intravenous administration Irinotecan Irinotecan - adverse effects Irinotecan - therapeutic use Leucovorin - adverse effects Leucovorin - therapeutic use Lymphopenia Magnetic resonance imaging Male Medical prognosis Metastases Metastasis Middle Aged Myocardial infarction Neoadjuvant Therapy Neurotoxicity Neutropenia Oxaliplatin Oxaliplatin - adverse effects Oxaliplatin - therapeutic use Patients Peripheral neuropathy Quality of Life Radiation therapy Rectal Neoplasms - mortality Rectal Neoplasms - psychology Rectal Neoplasms - therapy Rectum Response rates Standard of care Surgery Survival Tumors
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