Selectivity and potency of natural product PIM kinase inhibitors identified by in silico docking

PIM3 (Proviral Integration site for Maloney murine leukemia virus kinase 3) is a proto-oncogene with serine/threonine kinase activity that prevents apoptosis, promotes cell survival, and stimulates protein translation. In addition, PIM3 functions in inflammation and immunity pathways. PIM3 inhibitor...

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Veröffentlicht in:	Medicinal chemistry research 2021-05, Vol.30 (5), p.1117-1124
Hauptverfasser:	Russell, Michael H., Fazio, Nicholas F., Webster, Jace, Hansen, Marc D. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs Apoptosis Binding sites Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cell survival Inorganic Chemistry Kinases Leukemia Medicinal Chemistry Molecular structure Natural products Original Research Pharmacology/Toxicology Protein-serine/threonine kinase Selectivity Virtual libraries
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