Synthesis and Biological Evaluation of Quinazolonethiazoles as New Potential Conquerors towards Pseudomonas Aeruginosa

Main observation and conclusion Novel quinazolonthiazoles were designed and synthesized as new potential antimicrobial agents by facile multi‐step procedure from o‐aminobenzoic acids and 2‐acetylthiazole. A series of biological evaluation showed that compound 7d was the most effective quinazolonethi...

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Veröffentlicht in:	Chinese journal of chemistry 2021-05, Vol.39 (5), p.1093-1103
Hauptverfasser:	Wang, Jie, Battini, Narsaiah, Ansari, Mohammad Fawad, Zhou, Cheng‐He
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Antimicrobial Antimicrobial agents Bacteria Chloramphenicol Chloromycetin DNA DNA topoisomerase IV Drug design Drug development Drugs Hepatocytes Membrane permeability Norfloxacin Pharmacokinetics Pseudomonas aeruginosa Schiff bases Thiazole Toxicity
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