Circadian tau differences and rhythm associations in delayed sleep–wake phase disorder and sighted non-24-hour sleep–wake rhythm disorder
Abstract Study Objectives We investigated biological and behavioral rhythm period lengths (i.e. taus) of delayed sleep–wake phase disorder (DSWPD) and non-24-hour sleep–wake rhythm disorder (N24SWD). Based on circadian phase timing (temperature and dim light melatonin onset), DSWPD participants were...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2021-01, Vol.44 (1), p.1 |
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| creator | Micic, Gorica Lovato, Nicole Ferguson, Sally A Burgess, Helen J Lack, Leon |
| description | Abstract
Study Objectives
We investigated biological and behavioral rhythm period lengths (i.e. taus) of delayed sleep–wake phase disorder (DSWPD) and non-24-hour sleep–wake rhythm disorder (N24SWD). Based on circadian phase timing (temperature and dim light melatonin onset), DSWPD participants were dichotomized into a circadian-delayed and a circadian non-delayed group to investigate etiological differences.
Methods
Participants with DSWPD (n = 26, 17 m, age: 21.85 ± 4.97 years), full-sighted N24SWD (n = 4, 3 m, age: 25.75 ± 4.99 years) and 18 controls (10 m, age: 23.72 ± 5.10 years) participated in an 80-h modified constant routine. An ultradian protocol of 1-h “days” in dim light, controlled conditions alternated 20-min sleep/dark periods with 40-min enforced wakefulness/light. Subjective sleepiness ratings were recorded prior to every sleep/dark opportunity and median reaction time (vigilance) was measured hourly. Obtained sleep (sleep propensity) was derived from 20-min sleep/dark opportunities to quantify hourly objective sleepiness. Hourly core body temperature was recorded, and salivary melatonin assayed to measure endogenous circadian rhythms. Rhythm data were curved using the two-component cosine model.
Results
Patients with DSWPD and N24SWD had significantly longer melatonin and temperature taus compared to controls. Circadian non-delayed DSWPD had normally timed temperature and melatonin rhythms but were typically sleeping at relatively late circadian phases compared to those with circadian-delayed DSWPD.
Conclusions
People with DSWPD and N24SWD exhibit significantly longer biological circadian rhythm period lengths compared to controls. Approximately half of those diagnosed with DSWPD do not have abnormally delayed circadian rhythm timings suggesting abnormal phase relationship between biological rhythms and behavioral sleep period or potentially conditioned sleep-onset insomnia. |
| doi_str_mv | 10.1093/sleep/zsaa132 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2518715801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A681828747</galeid><oup_id>10.1093/sleep/zsaa132</oup_id><sourcerecordid>A681828747</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-b6cce2f8d74c2d307f1409d749e796f32bcfaa267673bb42e44bf26bf221c3303</originalsourceid><addsrcrecordid>eNqFkc9qFTEUxoMo9lpdupWAm26mzb_JzCzLxWqh0I2uQyY56aTeScZkBrld-QJd9Q19EuO9t0pBkBDCSX7fdw75EHpLySklHT_LG4Dp7C5rTTl7hla0rknVlafnaEWopFVLSX2EXuV8S0otOv4SHXEmaccEX6H7tU9GW68DnvWCrXcOEgQDGetgcRq28zBinXM0Xs8-hox9wBY2egsW75r__PHwXX8FPA06Q3HIMVlIO3n2N8NcuBBDxUQ1xCU91Rz8H0Wv0QunNxneHM5j9OXiw-f1p-rq-uPl-vyqMjWTc9VLY4C51jbCMMtJ46ggXak6aDrpOOuN05rJRja87wUDIXrHZNmMGs4JP0bv975Tit8WyLO6LaOF0lKxmrYNrVtC_1I3egPKBxfnpM3os1HnsqUtaxvRFOr0H1RZFkZvYgDny_0TQbUXmBRzTuDUlPyo01ZRon5nqnZfpA6ZFv7dYdilH8H-oR9DLMDJHojL9B-vX-6-r6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2518715801</pqid></control><display><type>article</type><title>Circadian tau differences and rhythm associations in delayed sleep–wake phase disorder and sighted non-24-hour sleep–wake rhythm disorder</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Micic, Gorica ; Lovato, Nicole ; Ferguson, Sally A ; Burgess, Helen J ; Lack, Leon</creator><creatorcontrib>Micic, Gorica ; Lovato, Nicole ; Ferguson, Sally A ; Burgess, Helen J ; Lack, Leon</creatorcontrib><description>Abstract
Study Objectives
We investigated biological and behavioral rhythm period lengths (i.e. taus) of delayed sleep–wake phase disorder (DSWPD) and non-24-hour sleep–wake rhythm disorder (N24SWD). Based on circadian phase timing (temperature and dim light melatonin onset), DSWPD participants were dichotomized into a circadian-delayed and a circadian non-delayed group to investigate etiological differences.
Methods
Participants with DSWPD (n = 26, 17 m, age: 21.85 ± 4.97 years), full-sighted N24SWD (n = 4, 3 m, age: 25.75 ± 4.99 years) and 18 controls (10 m, age: 23.72 ± 5.10 years) participated in an 80-h modified constant routine. An ultradian protocol of 1-h “days” in dim light, controlled conditions alternated 20-min sleep/dark periods with 40-min enforced wakefulness/light. Subjective sleepiness ratings were recorded prior to every sleep/dark opportunity and median reaction time (vigilance) was measured hourly. Obtained sleep (sleep propensity) was derived from 20-min sleep/dark opportunities to quantify hourly objective sleepiness. Hourly core body temperature was recorded, and salivary melatonin assayed to measure endogenous circadian rhythms. Rhythm data were curved using the two-component cosine model.
Results
Patients with DSWPD and N24SWD had significantly longer melatonin and temperature taus compared to controls. Circadian non-delayed DSWPD had normally timed temperature and melatonin rhythms but were typically sleeping at relatively late circadian phases compared to those with circadian-delayed DSWPD.
Conclusions
People with DSWPD and N24SWD exhibit significantly longer biological circadian rhythm period lengths compared to controls. Approximately half of those diagnosed with DSWPD do not have abnormally delayed circadian rhythm timings suggesting abnormal phase relationship between biological rhythms and behavioral sleep period or potentially conditioned sleep-onset insomnia.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsaa132</identifier><identifier>PMID: 32619243</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adolescent ; Adult ; Circadian Rhythm ; Health aspects ; Humans ; Insomnia ; Melatonin ; Sleep ; Sleep disorders ; Sleep Disorders, Circadian Rhythm ; Sleep Wake Disorders ; Young Adult</subject><ispartof>Sleep (New York, N.Y.), 2021-01, Vol.44 (1), p.1</ispartof><rights>Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com. 2020</rights><rights>Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-b6cce2f8d74c2d307f1409d749e796f32bcfaa267673bb42e44bf26bf221c3303</citedby><cites>FETCH-LOGICAL-c526t-b6cce2f8d74c2d307f1409d749e796f32bcfaa267673bb42e44bf26bf221c3303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32619243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Micic, Gorica</creatorcontrib><creatorcontrib>Lovato, Nicole</creatorcontrib><creatorcontrib>Ferguson, Sally A</creatorcontrib><creatorcontrib>Burgess, Helen J</creatorcontrib><creatorcontrib>Lack, Leon</creatorcontrib><title>Circadian tau differences and rhythm associations in delayed sleep–wake phase disorder and sighted non-24-hour sleep–wake rhythm disorder</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>Abstract
Study Objectives
We investigated biological and behavioral rhythm period lengths (i.e. taus) of delayed sleep–wake phase disorder (DSWPD) and non-24-hour sleep–wake rhythm disorder (N24SWD). Based on circadian phase timing (temperature and dim light melatonin onset), DSWPD participants were dichotomized into a circadian-delayed and a circadian non-delayed group to investigate etiological differences.
Methods
Participants with DSWPD (n = 26, 17 m, age: 21.85 ± 4.97 years), full-sighted N24SWD (n = 4, 3 m, age: 25.75 ± 4.99 years) and 18 controls (10 m, age: 23.72 ± 5.10 years) participated in an 80-h modified constant routine. An ultradian protocol of 1-h “days” in dim light, controlled conditions alternated 20-min sleep/dark periods with 40-min enforced wakefulness/light. Subjective sleepiness ratings were recorded prior to every sleep/dark opportunity and median reaction time (vigilance) was measured hourly. Obtained sleep (sleep propensity) was derived from 20-min sleep/dark opportunities to quantify hourly objective sleepiness. Hourly core body temperature was recorded, and salivary melatonin assayed to measure endogenous circadian rhythms. Rhythm data were curved using the two-component cosine model.
Results
Patients with DSWPD and N24SWD had significantly longer melatonin and temperature taus compared to controls. Circadian non-delayed DSWPD had normally timed temperature and melatonin rhythms but were typically sleeping at relatively late circadian phases compared to those with circadian-delayed DSWPD.
Conclusions
People with DSWPD and N24SWD exhibit significantly longer biological circadian rhythm period lengths compared to controls. Approximately half of those diagnosed with DSWPD do not have abnormally delayed circadian rhythm timings suggesting abnormal phase relationship between biological rhythms and behavioral sleep period or potentially conditioned sleep-onset insomnia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Circadian Rhythm</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Insomnia</subject><subject>Melatonin</subject><subject>Sleep</subject><subject>Sleep disorders</subject><subject>Sleep Disorders, Circadian Rhythm</subject><subject>Sleep Wake Disorders</subject><subject>Young Adult</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc9qFTEUxoMo9lpdupWAm26mzb_JzCzLxWqh0I2uQyY56aTeScZkBrld-QJd9Q19EuO9t0pBkBDCSX7fdw75EHpLySklHT_LG4Dp7C5rTTl7hla0rknVlafnaEWopFVLSX2EXuV8S0otOv4SHXEmaccEX6H7tU9GW68DnvWCrXcOEgQDGetgcRq28zBinXM0Xs8-hox9wBY2egsW75r__PHwXX8FPA06Q3HIMVlIO3n2N8NcuBBDxUQ1xCU91Rz8H0Wv0QunNxneHM5j9OXiw-f1p-rq-uPl-vyqMjWTc9VLY4C51jbCMMtJ46ggXak6aDrpOOuN05rJRja87wUDIXrHZNmMGs4JP0bv975Tit8WyLO6LaOF0lKxmrYNrVtC_1I3egPKBxfnpM3os1HnsqUtaxvRFOr0H1RZFkZvYgDny_0TQbUXmBRzTuDUlPyo01ZRon5nqnZfpA6ZFv7dYdilH8H-oR9DLMDJHojL9B-vX-6-r6Q</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Micic, Gorica</creator><creator>Lovato, Nicole</creator><creator>Ferguson, Sally A</creator><creator>Burgess, Helen J</creator><creator>Lack, Leon</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20210101</creationdate><title>Circadian tau differences and rhythm associations in delayed sleep–wake phase disorder and sighted non-24-hour sleep–wake rhythm disorder</title><author>Micic, Gorica ; Lovato, Nicole ; Ferguson, Sally A ; Burgess, Helen J ; Lack, Leon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-b6cce2f8d74c2d307f1409d749e796f32bcfaa267673bb42e44bf26bf221c3303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Circadian Rhythm</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Insomnia</topic><topic>Melatonin</topic><topic>Sleep</topic><topic>Sleep disorders</topic><topic>Sleep Disorders, Circadian Rhythm</topic><topic>Sleep Wake Disorders</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Micic, Gorica</creatorcontrib><creatorcontrib>Lovato, Nicole</creatorcontrib><creatorcontrib>Ferguson, Sally A</creatorcontrib><creatorcontrib>Burgess, Helen J</creatorcontrib><creatorcontrib>Lack, Leon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Micic, Gorica</au><au>Lovato, Nicole</au><au>Ferguson, Sally A</au><au>Burgess, Helen J</au><au>Lack, Leon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circadian tau differences and rhythm associations in delayed sleep–wake phase disorder and sighted non-24-hour sleep–wake rhythm disorder</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>44</volume><issue>1</issue><spage>1</spage><pages>1-</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Study Objectives
We investigated biological and behavioral rhythm period lengths (i.e. taus) of delayed sleep–wake phase disorder (DSWPD) and non-24-hour sleep–wake rhythm disorder (N24SWD). Based on circadian phase timing (temperature and dim light melatonin onset), DSWPD participants were dichotomized into a circadian-delayed and a circadian non-delayed group to investigate etiological differences.
Methods
Participants with DSWPD (n = 26, 17 m, age: 21.85 ± 4.97 years), full-sighted N24SWD (n = 4, 3 m, age: 25.75 ± 4.99 years) and 18 controls (10 m, age: 23.72 ± 5.10 years) participated in an 80-h modified constant routine. An ultradian protocol of 1-h “days” in dim light, controlled conditions alternated 20-min sleep/dark periods with 40-min enforced wakefulness/light. Subjective sleepiness ratings were recorded prior to every sleep/dark opportunity and median reaction time (vigilance) was measured hourly. Obtained sleep (sleep propensity) was derived from 20-min sleep/dark opportunities to quantify hourly objective sleepiness. Hourly core body temperature was recorded, and salivary melatonin assayed to measure endogenous circadian rhythms. Rhythm data were curved using the two-component cosine model.
Results
Patients with DSWPD and N24SWD had significantly longer melatonin and temperature taus compared to controls. Circadian non-delayed DSWPD had normally timed temperature and melatonin rhythms but were typically sleeping at relatively late circadian phases compared to those with circadian-delayed DSWPD.
Conclusions
People with DSWPD and N24SWD exhibit significantly longer biological circadian rhythm period lengths compared to controls. Approximately half of those diagnosed with DSWPD do not have abnormally delayed circadian rhythm timings suggesting abnormal phase relationship between biological rhythms and behavioral sleep period or potentially conditioned sleep-onset insomnia.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32619243</pmid><doi>10.1093/sleep/zsaa132</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-8105 |
| ispartof | Sleep (New York, N.Y.), 2021-01, Vol.44 (1), p.1 |
| issn | 0161-8105 1550-9109 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Circadian Rhythm Health aspects Humans Insomnia Melatonin Sleep Sleep disorders Sleep Disorders, Circadian Rhythm Sleep Wake Disorders Young Adult |
| title | Circadian tau differences and rhythm associations in delayed sleep–wake phase disorder and sighted non-24-hour sleep–wake rhythm disorder |
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