Cardiotoxic Effects of Micrurus surinamensis (Cuvier, 1817) Snake Venom
Micrurus surinamensis is a coral snake from the Elapidae family of wide distribution in Amazonia Forest. Its venom contains neurotoxins that induce muscular and respiratory paralysis; however, its cardiovascular action is not yet characterized. The aim of this study was to investigate the cardiotoxi...
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| Veröffentlicht in: | Cardiovascular toxicology 2021-06, Vol.21 (6), p.462-471 |
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| creator | Reis, Lilian de Paula Gonçalves Botelho, Ana Flávia Machado Novais, Clara Rojo Fiúza, Aparecida Tatiane Lino Barreto, Maira Souza Oliveira Ferreira, Marina Guimarães Bonilla, Cesar Chavez-Olórtegui, Carlos Melo, Marília Martins |
| description | Micrurus surinamensis
is a coral snake from the Elapidae family of wide distribution in Amazonia Forest. Its venom contains neurotoxins that induce muscular and respiratory paralysis; however, its cardiovascular action is not yet characterized. The aim of this study was to investigate the cardiotoxic effects caused by
M. surinamensis
poisoning in rodents. Twelve guinea pigs (
Cavia porcellus
) were distributed in two groups (
n
= 6) named as control and envenomed. The control group received 0.2 ml of PBS/BSA via intramuscular injection (IM), while envenomed animals received 0.75 µg of venom per g of body weight, also via IM. Electrocardiographic examination (ECG) and biochemical serum tests were conducted before and 2 h after inoculation. ECG of the envenomed animals revealed severe progressive arrhythmias including atrioventricular block, supraventricular, and ventricular extrasystoles. Serum biochemistry showed significant increase in CK, CK-MB, and LDH enzymes corroborating the skeletal and cardiac muscle damage. Myonecrosis and degeneration were observed in both skeletal and heart muscle; nevertheless, transmission electron microscopy revealed cardiac muscle fibers fragmentation. In conclusion,
M. surinamensis
venom has a potent cardiotoxic activity eliciting arrhythmogenic effects and heart damage after only 2 h of envenomation. |
| doi_str_mv | 10.1007/s12012-021-09640-7 |
| format | Article |
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is a coral snake from the Elapidae family of wide distribution in Amazonia Forest. Its venom contains neurotoxins that induce muscular and respiratory paralysis; however, its cardiovascular action is not yet characterized. The aim of this study was to investigate the cardiotoxic effects caused by
M. surinamensis
poisoning in rodents. Twelve guinea pigs (
Cavia porcellus
) were distributed in two groups (
n
= 6) named as control and envenomed. The control group received 0.2 ml of PBS/BSA via intramuscular injection (IM), while envenomed animals received 0.75 µg of venom per g of body weight, also via IM. Electrocardiographic examination (ECG) and biochemical serum tests were conducted before and 2 h after inoculation. ECG of the envenomed animals revealed severe progressive arrhythmias including atrioventricular block, supraventricular, and ventricular extrasystoles. Serum biochemistry showed significant increase in CK, CK-MB, and LDH enzymes corroborating the skeletal and cardiac muscle damage. Myonecrosis and degeneration were observed in both skeletal and heart muscle; nevertheless, transmission electron microscopy revealed cardiac muscle fibers fragmentation. In conclusion,
M. surinamensis
venom has a potent cardiotoxic activity eliciting arrhythmogenic effects and heart damage after only 2 h of envenomation.</description><identifier>ISSN: 1530-7905</identifier><identifier>EISSN: 1559-0259</identifier><identifier>DOI: 10.1007/s12012-021-09640-7</identifier><identifier>PMID: 33559838</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Arrhythmia ; Arrhythmias, Cardiac - chemically induced ; Arrhythmias, Cardiac - physiopathology ; Atrial Premature Complexes - chemically induced ; Atrial Premature Complexes - physiopathology ; Atrioventricular Block - chemically induced ; Atrioventricular Block - physiopathology ; Biomedical and Life Sciences ; Biomedicine ; Body weight ; Cardiac muscle ; Cardiology ; Cardiotoxicity ; Cardiotoxins ; Coral Snakes ; Creatine kinase ; Damage ; Degeneration ; EKG ; Elapid Venoms - toxicity ; Electrocardiogram ; Electrocardiography ; Enzymes ; Ethylenediaminetetraacetic acid ; Guinea Pigs ; Heart Rate - drug effects ; Inoculation ; Male ; Micrurus surinamensis ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - pathology ; Muscles ; Myocytes, Cardiac - drug effects ; Myocytes, Cardiac - metabolism ; Myocytes, Cardiac - ultrastructure ; Myonecrosis ; Necrosis ; Neurotoxins ; Paralysis ; Pharmacology/Toxicology ; Poisoning ; Poisonous snakes ; Skeletal muscle ; Snakes ; Time Factors ; Toxins ; Transmission electron microscopy ; Venom ; Ventricle ; Ventricular Premature Complexes - chemically induced ; Ventricular Premature Complexes - physiopathology</subject><ispartof>Cardiovascular toxicology, 2021-06, Vol.21 (6), p.462-471</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-514538cdff990969715c43cbfb4bca054eea944ffb8f1c96d8d67ce1a27996a13</citedby><cites>FETCH-LOGICAL-c442t-514538cdff990969715c43cbfb4bca054eea944ffb8f1c96d8d67ce1a27996a13</cites><orcidid>0000-0001-5204-0512</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12012-021-09640-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12012-021-09640-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33559838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reis, Lilian de Paula Gonçalves</creatorcontrib><creatorcontrib>Botelho, Ana Flávia Machado</creatorcontrib><creatorcontrib>Novais, Clara Rojo</creatorcontrib><creatorcontrib>Fiúza, Aparecida Tatiane Lino</creatorcontrib><creatorcontrib>Barreto, Maira Souza Oliveira</creatorcontrib><creatorcontrib>Ferreira, Marina Guimarães</creatorcontrib><creatorcontrib>Bonilla, Cesar</creatorcontrib><creatorcontrib>Chavez-Olórtegui, Carlos</creatorcontrib><creatorcontrib>Melo, Marília Martins</creatorcontrib><title>Cardiotoxic Effects of Micrurus surinamensis (Cuvier, 1817) Snake Venom</title><title>Cardiovascular toxicology</title><addtitle>Cardiovasc Toxicol</addtitle><addtitle>Cardiovasc Toxicol</addtitle><description>Micrurus surinamensis
is a coral snake from the Elapidae family of wide distribution in Amazonia Forest. Its venom contains neurotoxins that induce muscular and respiratory paralysis; however, its cardiovascular action is not yet characterized. The aim of this study was to investigate the cardiotoxic effects caused by
M. surinamensis
poisoning in rodents. Twelve guinea pigs (
Cavia porcellus
) were distributed in two groups (
n
= 6) named as control and envenomed. The control group received 0.2 ml of PBS/BSA via intramuscular injection (IM), while envenomed animals received 0.75 µg of venom per g of body weight, also via IM. Electrocardiographic examination (ECG) and biochemical serum tests were conducted before and 2 h after inoculation. ECG of the envenomed animals revealed severe progressive arrhythmias including atrioventricular block, supraventricular, and ventricular extrasystoles. Serum biochemistry showed significant increase in CK, CK-MB, and LDH enzymes corroborating the skeletal and cardiac muscle damage. Myonecrosis and degeneration were observed in both skeletal and heart muscle; nevertheless, transmission electron microscopy revealed cardiac muscle fibers fragmentation. In conclusion,
M. surinamensis
venom has a potent cardiotoxic activity eliciting arrhythmogenic effects and heart damage after only 2 h of envenomation.</description><subject>Animals</subject><subject>Arrhythmia</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Atrial Premature Complexes - chemically induced</subject><subject>Atrial Premature Complexes - physiopathology</subject><subject>Atrioventricular Block - chemically induced</subject><subject>Atrioventricular Block - physiopathology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body weight</subject><subject>Cardiac muscle</subject><subject>Cardiology</subject><subject>Cardiotoxicity</subject><subject>Cardiotoxins</subject><subject>Coral Snakes</subject><subject>Creatine kinase</subject><subject>Damage</subject><subject>Degeneration</subject><subject>EKG</subject><subject>Elapid Venoms - toxicity</subject><subject>Electrocardiogram</subject><subject>Electrocardiography</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Guinea Pigs</subject><subject>Heart Rate - drug effects</subject><subject>Inoculation</subject><subject>Male</subject><subject>Micrurus surinamensis</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscles</subject><subject>Myocytes, Cardiac - drug effects</subject><subject>Myocytes, Cardiac - metabolism</subject><subject>Myocytes, Cardiac - ultrastructure</subject><subject>Myonecrosis</subject><subject>Necrosis</subject><subject>Neurotoxins</subject><subject>Paralysis</subject><subject>Pharmacology/Toxicology</subject><subject>Poisoning</subject><subject>Poisonous snakes</subject><subject>Skeletal muscle</subject><subject>Snakes</subject><subject>Time Factors</subject><subject>Toxins</subject><subject>Transmission electron microscopy</subject><subject>Venom</subject><subject>Ventricle</subject><subject>Ventricular Premature Complexes - chemically induced</subject><subject>Ventricular Premature Complexes - physiopathology</subject><issn>1530-7905</issn><issn>1559-0259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtLAzEUhYMotlb_gAsZcKPgaJ4zybKUWoWKCx_bkMkkEu1MajIj-u9NrQ8EkSxuOPc7NzccAPYRPEUQlmcRYYhwDjHKoSgozMsNMESMiSQxsbm6kyQKyAZgJ8ZHCDHGBdsGA0ISxQkfgtlEhdr5zr86nU2tNbqLmbfZldOhD33MYh9cqxrTRhezo0n_4kw4yRBH5XF206onk92b1je7YMuqRTR7n3UE7s6nt5OLfH49u5yM57mmFHc5Q5QRrmtrhUg7ixIxTYmubEUrrSCjxihBqbUVt0iLouZ1UWqDFC6FKBQiI3C4nrsM_rk3sZOPvg9telJihjgrICTih3pQCyNda30XlG5c1HJcwoJwjnmZqNM_qHRq0zjtW2Nd0n8Z8Nqgg48xGCuXwTUqvEkE5SoSuY5EpkjkRyRyZTr43LivGlN_W74ySABZAzG12gcTfr70z9h3KJeTZA</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Reis, Lilian de Paula Gonçalves</creator><creator>Botelho, Ana Flávia Machado</creator><creator>Novais, Clara Rojo</creator><creator>Fiúza, Aparecida Tatiane Lino</creator><creator>Barreto, Maira Souza Oliveira</creator><creator>Ferreira, Marina Guimarães</creator><creator>Bonilla, Cesar</creator><creator>Chavez-Olórtegui, Carlos</creator><creator>Melo, Marília Martins</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-5204-0512</orcidid></search><sort><creationdate>20210601</creationdate><title>Cardiotoxic Effects of Micrurus surinamensis (Cuvier, 1817) Snake Venom</title><author>Reis, Lilian de Paula Gonçalves ; Botelho, Ana Flávia Machado ; Novais, Clara Rojo ; Fiúza, Aparecida Tatiane Lino ; Barreto, Maira Souza Oliveira ; Ferreira, Marina Guimarães ; Bonilla, Cesar ; Chavez-Olórtegui, Carlos ; Melo, Marília Martins</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-514538cdff990969715c43cbfb4bca054eea944ffb8f1c96d8d67ce1a27996a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Arrhythmia</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Arrhythmias, Cardiac - physiopathology</topic><topic>Atrial Premature Complexes - chemically induced</topic><topic>Atrial Premature Complexes - physiopathology</topic><topic>Atrioventricular Block - chemically induced</topic><topic>Atrioventricular Block - physiopathology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body weight</topic><topic>Cardiac muscle</topic><topic>Cardiology</topic><topic>Cardiotoxicity</topic><topic>Cardiotoxins</topic><topic>Coral Snakes</topic><topic>Creatine kinase</topic><topic>Damage</topic><topic>Degeneration</topic><topic>EKG</topic><topic>Elapid Venoms - toxicity</topic><topic>Electrocardiogram</topic><topic>Electrocardiography</topic><topic>Enzymes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Guinea Pigs</topic><topic>Heart Rate - drug effects</topic><topic>Inoculation</topic><topic>Male</topic><topic>Micrurus surinamensis</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscles</topic><topic>Myocytes, Cardiac - drug effects</topic><topic>Myocytes, Cardiac - metabolism</topic><topic>Myocytes, Cardiac - ultrastructure</topic><topic>Myonecrosis</topic><topic>Necrosis</topic><topic>Neurotoxins</topic><topic>Paralysis</topic><topic>Pharmacology/Toxicology</topic><topic>Poisoning</topic><topic>Poisonous snakes</topic><topic>Skeletal muscle</topic><topic>Snakes</topic><topic>Time Factors</topic><topic>Toxins</topic><topic>Transmission electron microscopy</topic><topic>Venom</topic><topic>Ventricle</topic><topic>Ventricular Premature Complexes - chemically induced</topic><topic>Ventricular Premature Complexes - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reis, Lilian de Paula Gonçalves</creatorcontrib><creatorcontrib>Botelho, Ana Flávia Machado</creatorcontrib><creatorcontrib>Novais, Clara Rojo</creatorcontrib><creatorcontrib>Fiúza, Aparecida Tatiane Lino</creatorcontrib><creatorcontrib>Barreto, Maira Souza Oliveira</creatorcontrib><creatorcontrib>Ferreira, Marina Guimarães</creatorcontrib><creatorcontrib>Bonilla, Cesar</creatorcontrib><creatorcontrib>Chavez-Olórtegui, Carlos</creatorcontrib><creatorcontrib>Melo, Marília Martins</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Cardiovascular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reis, Lilian de Paula Gonçalves</au><au>Botelho, Ana Flávia Machado</au><au>Novais, Clara Rojo</au><au>Fiúza, Aparecida Tatiane Lino</au><au>Barreto, Maira Souza Oliveira</au><au>Ferreira, Marina Guimarães</au><au>Bonilla, Cesar</au><au>Chavez-Olórtegui, Carlos</au><au>Melo, Marília Martins</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiotoxic Effects of Micrurus surinamensis (Cuvier, 1817) Snake Venom</atitle><jtitle>Cardiovascular toxicology</jtitle><stitle>Cardiovasc Toxicol</stitle><addtitle>Cardiovasc Toxicol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>21</volume><issue>6</issue><spage>462</spage><epage>471</epage><pages>462-471</pages><issn>1530-7905</issn><eissn>1559-0259</eissn><abstract>Micrurus surinamensis
is a coral snake from the Elapidae family of wide distribution in Amazonia Forest. Its venom contains neurotoxins that induce muscular and respiratory paralysis; however, its cardiovascular action is not yet characterized. The aim of this study was to investigate the cardiotoxic effects caused by
M. surinamensis
poisoning in rodents. Twelve guinea pigs (
Cavia porcellus
) were distributed in two groups (
n
= 6) named as control and envenomed. The control group received 0.2 ml of PBS/BSA via intramuscular injection (IM), while envenomed animals received 0.75 µg of venom per g of body weight, also via IM. Electrocardiographic examination (ECG) and biochemical serum tests were conducted before and 2 h after inoculation. ECG of the envenomed animals revealed severe progressive arrhythmias including atrioventricular block, supraventricular, and ventricular extrasystoles. Serum biochemistry showed significant increase in CK, CK-MB, and LDH enzymes corroborating the skeletal and cardiac muscle damage. Myonecrosis and degeneration were observed in both skeletal and heart muscle; nevertheless, transmission electron microscopy revealed cardiac muscle fibers fragmentation. In conclusion,
M. surinamensis
venom has a potent cardiotoxic activity eliciting arrhythmogenic effects and heart damage after only 2 h of envenomation.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33559838</pmid><doi>10.1007/s12012-021-09640-7</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5204-0512</orcidid></addata></record> |
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| ispartof | Cardiovascular toxicology, 2021-06, Vol.21 (6), p.462-471 |
| issn | 1530-7905 1559-0259 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Arrhythmia Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - physiopathology Atrial Premature Complexes - chemically induced Atrial Premature Complexes - physiopathology Atrioventricular Block - chemically induced Atrioventricular Block - physiopathology Biomedical and Life Sciences Biomedicine Body weight Cardiac muscle Cardiology Cardiotoxicity Cardiotoxins Coral Snakes Creatine kinase Damage Degeneration EKG Elapid Venoms - toxicity Electrocardiogram Electrocardiography Enzymes Ethylenediaminetetraacetic acid Guinea Pigs Heart Rate - drug effects Inoculation Male Micrurus surinamensis Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscles Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Myonecrosis Necrosis Neurotoxins Paralysis Pharmacology/Toxicology Poisoning Poisonous snakes Skeletal muscle Snakes Time Factors Toxins Transmission electron microscopy Venom Ventricle Ventricular Premature Complexes - chemically induced Ventricular Premature Complexes - physiopathology |
| title | Cardiotoxic Effects of Micrurus surinamensis (Cuvier, 1817) Snake Venom |
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