Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident

The 1986 Chernobyl nuclear power plant accident increased papillary thyroid carcinoma (PTC) incidence in surrounding regions, particularly for radioactive iodine ( I)-exposed children. We analyzed genomic, transcriptomic, and epigenomic characteristics of 440 PTCs from Ukraine (from 359 individuals...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-05, Vol.372 (6543)
Hauptverfasser:	Morton, Lindsay M, Karyadi, Danielle M, Stewart, Chip, Bogdanova, Tetiana I, Dawson, Eric T, Steinberg, Mia K, Dai, Jieqiong, Hartley, Stephen W, Schonfeld, Sara J, Sampson, Joshua N, Maruvka, Yosef E, Kapoor, Vidushi, Ramsden, Dale A, Carvajal-Garcia, Juan, Perou, Charles M, Parker, Joel S, Krznaric, Marko, Yeager, Meredith, Boland, Joseph F, Hutchinson, Amy, Hicks, Belynda D, Dagnall, Casey L, Gastier-Foster, Julie M, Bowen, Jay, Lee, Olivia, Machiela, Mitchell J, Cahoon, Elizabeth K, Brenner, Alina V, Mabuchi, Kiyohiko, Drozdovitch, Vladimir, Masiuk, Sergii, Chepurny, Mykola, Zurnadzhy, Liudmyla Yu, Hatch, Maureen, Berrington de Gonzalez, Amy, Thomas, Gerry A, Tronko, Mykola D, Getz, Gad, Chanock, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Accidents Adolescent Adult Cancer Chernobyl Nuclear Accident Child Child, Preschool DNA Copy Number Variations DNA methylation Epigenome Female Gene Expression Profiling Genes, ras Genetic Variation Humans Infant Iodine Radioisotopes Kinases Loss of Heterozygosity Male Middle Aged Mutation Neoplasms, Radiation-Induced - genetics Nuclear accidents Nuclear accidents & safety Nuclear Energy Nuclear power plants Papillary thyroid cancer Proto-Oncogene Proteins B-raf - genetics Radiation Radiation Dosage Radioactive fallout RNA-Seq Thyroid Thyroid cancer Thyroid Cancer, Papillary - etiology Thyroid Cancer, Papillary - genetics Thyroid Gland - physiology Thyroid Gland - radiation effects Thyroid Neoplasms - etiology Thyroid Neoplasms - genetics Translocation, Genetic Ukraine Whole Genome Sequencing Young Adult
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