Intergenerational thyroid hormone homeostasis imbalance in cerebellum of rats perinatally exposed to glyphosate‐based herbicide

Agrochemicals became a public health concern due to increased human exposure and possible endocrine disruption effects in several organs, including the brain. Thyroid hormones controls neurodevelopment, which turn them sensitive to endocrine disruptors (EDs). In this work, we evaluated the effect of...

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Veröffentlicht in:	Environmental toxicology 2021-06, Vol.36 (6), p.1031-1042
Hauptverfasser:	Costa Reis, Luã Tainã, Souza, Janaina, Herai, Roberto, Cunha, Eduardo Brunetti, Pereira Soares, Janaina, El‐Bachá, Ramon, Silva, Victor, Romano, Marco, Romano, Renata, Chiamolera, Maria, Giannocco, Gisele, Costa, Silvia, Silva, Magnus Régios, Cunha Lima, Suzana
Format:	Artikel
Sprache:	eng
Schlagworte:	Agrochemicals Animals Body organs Cerebellum endocrine disruptor Endocrine disruptors epigenetic Epigenetics Exposure Female Gene expression Gestation Glial fibrillary acidic protein Glycine - analogs & derivatives Glyphosate glyphosate‐based herbicide Herbicides Herbicides - toxicity Homeostasis Hormones intergenerational effect Male Metabolomics non‐monotonic dose response Offspring Organs Pregnancy Proteins Public health Rats Rats, Wistar Thyroid Thyroid Gland thyroid hormone Thyroid hormone receptors Thyroid Hormones
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